Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model by Genmin Lu (5029949)

“…<div><p>Introduction</p><p>Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa, rapidly reverses the anticoagulation effects of direct and indirect FXa inhibitors.…”

A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters by Awad A.M.

“…As the drill pipe rotational speed increased, the pressure drop decreased slightly until a critical rotatory speed was reached, thereafter, the pressure drop increased markedly. …”
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<i>GADD45a</i> promoter activity and functional promoter region in response to mechanical stress. by Sumegha Mitra (579813)

“…Comparatively, 18% CS-induced luciferase activity was significantly decreased in 0.8 kb, 0.4 kb and 0.2 kb fragments. (<b>D</b>) <i>In silico</i> analysis of <i>GADD45a</i> promoter region −371 to −133 by Genomatix predicted binding sites for transcription factor SP1. …”

Post-hospital mortality in children aged 2-12 years in Tanzania: A prospective cohort study by Duncan K. Hau (5628965)

“…Factors associated with mortality were determined using Cox regression analysis.</p><p>Results</p><p>A total of 506 participants were enrolled. In-hospital mortality rate was 7.7% (39/506). …”

Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population by Xiaomu Kong (447734)

Image1_Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study.pdf by Maria Consiglia Trotta (6243830)

“…Introduction:<p>The purine analog 6-thioguanine (6TG), an old drug approved in the 60s to treat acute myeloid leukemia (AML), was tested in the diabetic retinopathy (DR) experimental in vivo setting along with a molecular modeling approach.</p>Methods:<p>A computational analysis was performed to investigate the interaction of 6TG with MC1R and MC5R. …”

Robotic Right Lower Lobe Anteromedial Basilar (S7 + S8) Segmentectomy: A Case Report and Discussion by Ankit Dhamija (7901640)

“…This is especially evident in patients with emphysema and obesity. The authors provide a video and description of a patient with a nodule isolated to S7+S8 of the right lower lobe.…”

ChIP Reveals That RPA Is a Limiting Factor in <i>dmc1Δ</i> Cells by Rebecca Johnson (77303)

“…The difference in ChIP efficiencies for wild-type and <i>dmc1</i>Δ cells is greatest for the site far from VDE-DSB1, implying that as resection proceeds it becomes more difficult to compete for Rfa1, which may be stably bound to ssDNA created earlier, close to DSB sites.</p><p>(A) Close to a Spo11-DSB hotspot, the ChIP enrichment decreases with repair in wild-type cells but not in <i>dmc1</i>Δ cells.…”

Data_Sheet_1_A New Predictive Model for the Prognosis of MDA5+ DM-ILD.PDF by Qian Niu (425660)

“…Poor prognosis was found more frequently in patients who were older, clinically amyopathic variant of dermatomyositis (CADM), and/or with short duration, short interval of DM and ILD, long length of stay, fever, dyspnea, non-arthralgia, pulmonary infection, pleural effusion (PE), high total computed tomography scores (TCTs), ground-glass opacity (GGO), consolidation score, reticular score and fibrosis score, decreased forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), albumin, A/G, glomerular filtration rate (GFR) and tumor necrosis factor α (TNFα), high titer of anti-MDA5, proteinuria, high levels of monocyte, lactate dehydrogenase (LDH), ferritin (FER), neuron specific enolase (NSE) and glucocorticoid, antibiotic, antiviral, and non-invasive positive pressure ventilation (NPPV). …”

Cryo-EM structures of Map1 bound to ribosomes via expansion segment ES27a. by Alexandra G. Knorr (15333351)

“…<p>(<b>A</b>) Concentrated eluate obtained from Map1-TAP affinity purification shown on a 12% Nu-PAGE. …”

PRMT5 stabilizes vCyclin protein expression in a manner dependent on its methyltransferase activity. by Danping Niu (10912688)

“…<p>(A-B) Effect of PRMT5 on vCyclin expression. First, HEK293T cells were cotransfected with fixed amounts of vCyclin expression plasmid and increasing amounts of PRMT5 expression plasmids. …”

Why Do People Migrate Irregularly? Evidence From a Lab-in-the-Field Experiment in West Africa by Tijan Bah (18888085)

“…In this context, our experimental results show that providing potential migrants with official numbers on the probability of getting a legal residence permit decreases their likelihood of migration by 2.88 percentage points (pp), while information on the death risk of migrating increases their likelihood of migration by 2.29 pp—although the official numbers should be regarded as a lower bound to actual mortality. …”

Ccr7 inhibits β-catenin activity via a Gsk3β-indepenedent mechanism. by Shu-Yu Wu (129447)

“…Compared to control (a, d), <i>ccr7</i> RNA overexpressing blastulae showed strongly decreased (b, e), while MO1-<i>ccr7</i> injected blastulae showed increased, ΔNβ-catenin-GFP signal (c, f). …”

Bistable pattern formation by JNK/AP-1 and JAK/STAT signaling by a mutual repression motif. by Janhvi Jaiswal (14266407)

“…<b>(C)</b> The steady-state patterns are classified as “simple” bistable when JAK/STAT decreases and JNK/AP-1 increases in space with a relative change greater than 10% (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001665#sec011" target="_blank">Materials and methods</a> for details). …”

Effect of sodium bicarbonate on prolonged running performance: A randomized, double-blind, cross-over study by Tanja Freis (4348774)

“…</p><p>Trial registration</p><p>German Clinical Trials Register (DRKS) <a href="https://clinicaltrials.gov/ct2/show/DRKS00011284" target="_blank">DRKS00011284</a>.…”

A model for SOX9 control of differentiation phase–specific gene expression in growth plate chondrocytes. by Victor Y. L. Leung (198251)

“…Concomitantly <i>Col2a1</i> expression is markedly decreased. SOX9 therefore controls differentiation-phase specific gene expression in chondrocytes through direct and indirect mechanisms. …”

WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism by Li-Ting Wang (480568)

“…In fact, WLS was discovered to integrate a protein complex in N-glycan-dependent and WLS domain-selective manners, comprising ER stress sensors and lectin chaperones. …”

Image_1_Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D3 Receptor... by Jan Kehr (8292456)

“…As measured by microdialysis, the highest dose of cariprazine prevented a PD-induced decrease in DA levels (40–80 min post PD dose) in the medial prefrontal cortex (mPFC), whereas aripiprazole did not have a significant effect. …”

Table_1_Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D3 Receptor... by Jan Kehr (8292456)

“…As measured by microdialysis, the highest dose of cariprazine prevented a PD-induced decrease in DA levels (40–80 min post PD dose) in the medial prefrontal cortex (mPFC), whereas aripiprazole did not have a significant effect. …”

Identification of <em>IGF1</em>, <em>SLC4A4</em>, <em>WWOX</em>, and <em>SFMBT1</em> as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association S... by Hsin-Chou Yang (19577)

“…<em>SLC4A4</em>, which encodes the electrogenic sodium bicarbonate cotransporter 1, is associated with decreased body weight/size and abnormal ion homeostasis in mice. …”