Image_2_TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer.TIF by Mengdi Yang (8995346)

“…<p>The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC tumor suppressor and potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. …”

Table_2_A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling.xlsx by Claudia C. Rathje (7482146)

“…Consistent with the fly model, we observe a reduction in PI31 levels in mutant mice; however, there is no alteration in proteasome activity in whole mouse testes. …”

Table1_Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis.docx by Xiaojuan Huang (1957396)

“…ANTXR2 expression in the liver endothelium of wild-type (WT) mice significantly decreased after a 4-time sequential injection of carbon tetrachloride (CCl₄) to induce liver fibrosis. …”

Image_2_A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency.jpeg by Tao Qin (177288)

“…Targeted gene panel sequencing revealed a novel homozygous missense mutation in the IKBKB gene of a patient with immune dysregulation and combined T and B cell functional defects. …”

RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats by Christopher J. Lynch (210400)

“…Male Sprague-Dawley rats were infused intravenously with vehicle or olanzapine for 24h using a dose leading to a mild hyperglycemia. RNA-Seq was performed on gastrocnemius muscle, followed by alignment of the data with the Rat Genome Assembly 5.0. …”

Video_1_Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.MP4 by Ravikanth Velagapudi (7880072)

“…<p>Postoperative delirium is a frequent and debilitating complication, especially amongst high risk procedures such as orthopedic surgery, and its pathogenesis remains unclear. …”

Table_1_Macular Vessel Density Changes in Young Adults With High Myopia: A Longitudinal Study.DOCX by Ya Shi (3407390)

“…</p><p>Results: The macular vessel density significantly decreased in young myopes after a 21-month follow up (p < 0.05), with variations among sectors. …”

Image5_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…It is anticipated that ocean warming may cause decreased biodiversity in marine tropical areas, as increasing temperatures may lead to the development of a new thermal niche in these regions. …”

The Asian house shrew <i>Suncus murinus</i> as a reservoir and source of human outbreaks of plague in Madagascar by Soanandrasana Rahelinirina (179752)

“…<i>murinus</i> and <i>Xenopsylla cheopis</i> since the epidemics appears to have decreased the frequency of spillover events to the more susceptible rats, which act as a source of infection for humans. …”

Table_2_Mendelian randomization analysis revealed a gut microbiota–mammary axis in breast cancer.xlsx by Shuwan Zhang (457893)

“…For Her2+ breast cancer, an increased abundance of Genus_Ruminococcus2 was associated with a decreased risk (OR = 0.77, p = 4.91E−04, FDR = 0.04), whereas an increased abundance of Genus_Erysipelatoclostridium was associated with an increased risk (OR = 1.25, p = 6.58E−04, FDR = 0.04). …”

Image_4_The prevalence and associated factors of dysphagia in Parkinson's disease: A systematic review and meta-analysis.TIF by Siyuan Gong (4531207)

“…The last search was conducted on June 28, 2022. Finally, a total of 58 studies including 60 observations with 20,530 PD patients were included in our meta-analysis.…”

Increased Apoptosis after Autoimmune Regulator Expression in Epithelial Cells Revealed by a Combined Quantitative Proteomics Approach by Nuria Colomé (1863916)

“…The results showed increased levels of several chaperones, (HSC70, HSP27 and tubulin-specific chaperone A) in AIRE-expressing cells, while various cytoskeleton interacting proteins, that is, transgelin, caldesmon, tropomyosin alpha-1 chain, myosin regulatory light polypeptide 9, and myosin-9, were decreased. …”

<i>In Vitro</i> Ischemia Triggers a Transcriptional Response to Down-Regulate Synaptic Proteins in Hippocampal Neurons by Joana Fernandes (587970)

“…Additionally, OGD decreased the mRNA and protein expression levels of the GluA1 AMPA receptor subunit as well as the GluN2A and GluN2B subunits of NMDA receptors, but increased the mRNA expression of the GluN3A subunit, thus altering the composition of ionotropic glutamate receptors in hippocampal neurons. …”

Table 1_A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism.xlsx by Shiben Zhu (19159465)

“…Other MR methods exhibited a consistent trend in the impact of TL on hyperthyroidism. …”

DataSheet1_CK2β Is a Gatekeeper of Focal Adhesions Regulating Cell Spreading.zip by Odile Filhol (124715)

“…Herein, using phosphotyrosine enrichment coupled with affinity capture and proteomic analysis, we show that decreased expression of CK2β in MCF10A mammary epithelial cells triggers the phosphorylation of a number of proteins on tyrosine residues and promotes the striking activation of the FAK1-Src-PAX1 signaling pathway. …”

Image1_Seawater temperature drives the diversity of key cyanobacteria (Synechococcus and Prochlorococcus) in a warming sea.tiff by Alexandra Coello-Camba (6489533)

“…It is anticipated that ocean warming may cause decreased biodiversity in marine tropical areas, as increasing temperatures may lead to the development of a new thermal niche in these regions. …”

Image_3_Auranofin coated catheters inhibit bacterial and fungal biofilms in a murine subcutaneous model.tif by LewisOscar Felix (13135377)

“…To reduce microbial adhesion, murine and human catheters were coated with polyurethane and auranofin using a dip coating method and compared to non-coated materials. …”

Image_4_Auranofin coated catheters inhibit bacterial and fungal biofilms in a murine subcutaneous model.tif by LewisOscar Felix (13135377)

“…To reduce microbial adhesion, murine and human catheters were coated with polyurethane and auranofin using a dip coating method and compared to non-coated materials. …”

<i>Ptp4a3</i> is expressed in AOM-DSS derived colon tumors and normal tissue. by Mark W. Zimmerman (395901)

“…<i>Ptp4a3</i> was elevated 3.7-fold (** = p<0.01), while <i>Ptp4a1</i> and <i>Ptp4a2</i> levels were significantly decreased (* = p<0.0001 and p<0.05, respectively) (n = 15, bars  =  SEM). …”

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system by M.C.O. Citó (6516527)

“…<div><p>Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. …”