Image_3_Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside.TIF by Ilia Y. Bozo (10095142)

“…This advanced combined therapy medicinal product had no cytotoxic effects in vitro, slightly decreased bone marrow mesenchymal stromal cell (MSC) doubling time, and was characterized by a prolonged level of gene construct delivery in vivo in a luciferase bioimaging assay. …”

Table_1_Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside.DOCX by Ilia Y. Bozo (10095142)

“…This advanced combined therapy medicinal product had no cytotoxic effects in vitro, slightly decreased bone marrow mesenchymal stromal cell (MSC) doubling time, and was characterized by a prolonged level of gene construct delivery in vivo in a luciferase bioimaging assay. …”

Video_3_Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy.MP4 by Daisuke Hasegawa (239088)

“…<p>Epilepsy surgery is a common therapeutic option in humans with drug-resistant epilepsy. …”

Association of Promoter Methylation of <i>RUNX3</i> Gene with the Development of Esophageal Cancer: A Meta Analysis by Yi Wang (32470)

“…<div><p>Background</p><p>Runt-related transcription factor 3 (<i>RUNX3</i>) is a member of the runt-domain family of transcription factors. …”

Experimental Gingivitis Induces Systemic Inflammatory Markers in Young Healthy Individuals: A Single-Subject Interventional Study by Jörg Eberhard (280441)

“…This local inflammation was associated with a systemic increase in hsCRP (0.24 mg/L, <em>P</em> = 0.038), IL-6 (12.52 ng/L, <em>P</em> = 0.0002) and MCP-1 (9.10 ng/l, <em>P</em> = 0.124) in peripheral blood samples between baseline and day 21, which decreased at day 42. …”

Image_5_Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.tiff by Matteo Trudu (13758211)

“…Altogether, our results reveal a novel direct pro-survival effect of arginine deprivation on myeloma cells, with potential therapeutic implications.…”

Influence of androgen deprivation therapy on serum urate levels in patients with prostate cancer: A retrospective observational study by Jun Won Park (3607442)

“…</p><p>Methods</p><p>We retrospectively enrolled a total of 489 prostate cancer patients with available serum urate levels at baseline and 3 and 6 months after ADT (n = 150) or prostate surgery (n = 339). …”

Interactive Regulation between Aliphatic Hydroxylation and Aromatic Hydroxylation of Thaxtomin D in TxtC: A Theoretical Investigation by Chang Yuan (6918818)

“…TxtC is an unusual bifunctional cytochrome P450 that is able to perform sequential aliphatic and aromatic hydroxylation of the diketopiperazine substrate thaxtomin D in two distinct sites to produce thaxtomin A. Though the X-ray structure of TxtC complexed with thaxtomin D revealed a binding mode for its aromatic hydroxylation, the preferential hydroxylation site is aliphatic C₁₄. …”

Image6_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…<p>Background: Previous observational studies have suggested that circulating adipokine concentrations are related to a greater risk of venous thromboembolism (VTE). …”

Table2_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.DOCX by Weizhong Xiao (14847373)

“…<p>Background: Previous observational studies have suggested that circulating adipokine concentrations are related to a greater risk of venous thromboembolism (VTE). …”

Image_1_Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.tiff by Matteo Trudu (13758211)

“…Altogether, our results reveal a novel direct pro-survival effect of arginine deprivation on myeloma cells, with potential therapeutic implications.…”

Image_4_Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.tiff by Matteo Trudu (13758211)

“…Altogether, our results reveal a novel direct pro-survival effect of arginine deprivation on myeloma cells, with potential therapeutic implications.…”

Table_1_Mendelian randomization suggests a causal relationship between gut dysbiosis and thyroid cancer.xlsx by Feng Zhu (685)

“…However, the exact nature of the causal relationship between them remains uncertain.</p>Methods<p>A bidirectional two-sample Mendelian randomization (TSMR) analysis was conducted to assess the causal connection between gut microbiota (18,340 individuals) and TC (6,699 cases combined with 1,613,655 controls) using data from a genome-wide association study (GWAS). …”

Role of NFκB in PEL cell lines (A) Constitutive expression of NFkB in PEL cells. by Azhar R. Hussain (154380)

“…<p>Nuclear extracts from BC1, BC3, BCBL1 and HBL6 cell lines were prepared as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039945#s2" target="_blank">material and Methods</a> and electrophoretic mobility shift assay (EMSA) was performed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039945#s2" target="_blank">Materials and Methods</a>. …”

Image_1_Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.tiff by Matteo Trudu (13758211)

“…Altogether, our results reveal a novel direct pro-survival effect of arginine deprivation on myeloma cells, with potential therapeutic implications.…”

<i>Euterpe oleracea</i> Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis by Daniel Escorsim Machado (3350489)

“…A reduction in immunostaining and mRNA expression of VEGF, MMP-9 and COX-2 was observed, and F4-80 was lower in the treated group than the control group. …”

DataSheet2_Influence of Menisci on Tibiofemoral Contact Mechanics in Human Knees: A Systematic Review.PDF by Matthias Sukopp (3987356)

“…Studies were identified through a systematic literature search in Cochrane, PubMed and Web of Science databases. …”

Image_3_Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma.tiff by Matteo Trudu (13758211)

“…Altogether, our results reveal a novel direct pro-survival effect of arginine deprivation on myeloma cells, with potential therapeutic implications.…”

Image_1_CTNNB1 Alternation Is a Potential Biomarker for Immunotherapy Prognosis in Patients With Hepatocellular Carcinoma.pdf by Lin Chen (54305)

“…The results of the tumor immune microenvironment (TIME) analysis showed that patients with CTNNB1-MUT had significantly reduced activated immune cells [such as T cells, B cells, M1-type macrophages, and dendritic cells (DCs)], significantly increased M2-type macrophages, a significantly decreased expression of immunostimulating molecules, low activity of the immune activation pathways (cytokine pathway, immune cell activation and recruitment) and highly active immune depletion pathways (fatty acid metabolism, cholesterol metabolism, and Wnt pathway).…”

Image2_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…<p>Background: Previous observational studies have suggested that circulating adipokine concentrations are related to a greater risk of venous thromboembolism (VTE). …”