Divergent signalling pathways mediate the effects of Aβ on Homer1b and Shank1 cluster dispersal. by Francesco Roselli (211670)

“…Wort+Aβ and Wort alone; p<0.05). Notably, wortmannin itself decreased Shank1 (but not Homer1b) cluster size (74.3±10.3%, cf. …”

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis by Frank Kloprogge (5374169)

“…</p><p>Methods and findings</p><p>A search in PubMed, Embase, ClinicalTrials.gov, Google Scholar, conference proceedings, and the WorldWide Antimalarial Resistance Network (WWARN) pharmacology database identified 31 relevant clinical studies published between 1 January 1990 and 31 December 2012, with 4,546 patients in whom lumefantrine concentrations were measured. …”

Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique by Anna E. Phillips (4050331)

“…<i>haematobium</i> was seen in adults even in the SBT arms implying the rate of transmission in the community had been decreased, even where only school children have been treated, which has significant logistical and cost-saving implications for a national control programme in justifying CWT.…”

Current situation and progress toward the 2030 health-related Sustainable Development Goals in China: A systematic analysis by Shu Chen (363692)

“…<div><p>Background</p><p>The Sustainable Development Goals (SDGs), adopted by all United Nations (UN) member states in 2015, established a set of bold and ambitious health-related targets to achieve by 2030. …”

Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies by Germán D. Carrasquilla (4600603)

“…Our results suggest that the initiation of HT 0–5 years after menopause onset, as compared to never use, is associated with a decreased risk of stroke and haemorrhagic stroke. …”

Substituent Effect on the Luminescent Properties of a Series of Deep Blue Emitting Mixed Ligand Ir(III) Complexes by Yi-Yeol Lyu (2540962)

“…The <b>(P3)F2M</b> complex shows a maximum external quantum efficiency (η_ex) of 2%, a maximum luminance efficiency (η_L) of 4.13 cd/A at 0.04 mA/cm², and a maximum brightness of 7200 cd/m² with a shift of the Commission Internationale de L'Eclairage (CIE) coordinates from (0.14, 0.15) in film PL to (0.19, 0.34) in EL.…”

Substituent Effect on the Luminescent Properties of a Series of Deep Blue Emitting Mixed Ligand Ir(III) Complexes by Yi-Yeol Lyu (2540962)

“…The <b>(P3)F2M</b> complex shows a maximum external quantum efficiency (η_ex) of 2%, a maximum luminance efficiency (η_L) of 4.13 cd/A at 0.04 mA/cm², and a maximum brightness of 7200 cd/m² with a shift of the Commission Internationale de L'Eclairage (CIE) coordinates from (0.14, 0.15) in film PL to (0.19, 0.34) in EL.…”

Comparison of our CCR5-CCL5-I and -II systems with the experimental structure (PDB ID: 7O7F), a complex of CCR5 with a modified CCL5 chemokine, the super-agonist [6P4]CCL5. by Guillermo Goode-Romero (11476663)

“…<p>(A) The RMSD of the backbone with a defined secondary structure (<i>i</i>.…”

LET-653 is a luminal ZP protein that shapes <i>C</i>. <i>elegans</i> tubes. by Jennifer D. Cohen (2902514)

“…<p>A) Diagram of LET-653 isoform b, on which all structure/function constructs were based. …”

Status of methylation at the CpG site in the maspin promoter region of TEV-1 cells upon hypoxia and DI A-D: Bisulfite sequencing revealed a methylated CpG island in the maspin prom... by Xinwei Shi (782237)

Table 1_A dosimetric comparison of non-coplanar volumetric modulated arc therapy and non-coplanar fixed field intensity modulated radiation therapy in hippocampus-avoidance whole-b... by Huaqu Zeng (20601563)

“…</p>Method<p>A total of 22 patients with brain metastases were retrospectively enrolled. …”

DataSheet_1_Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage... by Archana Gopalakrishnan (13252188)

“…Treatment with pioglitazone (PGZ), a PPARγ ligand, increased survival from PR8 infection, decreased M1 macrophage gene expression, and increased PPARγ mRNA in lungs. …”

Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells by Abdulrahman, Nabeel

“…Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining drugs with different mechanisms is being investigated as a means to overcome these challenges. …”
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Glomeruli of PodoPalld129-/- mice have dilated capillaries and show a reduced expression of integrin α8. by Nadine Artelt (5908337)

“…(D) Western blot quantification of Itga8 showed a significant decrease in 6 months old PodoPalld129-/- glomeruli (KO) compared to the control (WT; 6 months old PodoPalld129+/+ glomeruli protein lysates). …”

A reduction in brain mass and cortical volume seen in the adult <i>Cln6^nclf</i> mouse. by Jeremy P. Morgan (479017)

“…<p>Brain mass was assessed in the <i>Cln6^nclf</i>, as a decrease in brain mass is often seen in vLINCL patients. …”

Quantitative and semi-quantitative assessment of tissue clearance methods as applied to <i>A</i>. <i>stephensi</i> mosquitoes. by Mariana De Niz (724286)

“…Only BABB resulted in tissue shrinkage leading to a median size decrease of 26% (SD = 13). Sample size for each method was n = 50 mosquitoes. …”

GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex by Yuting Zhao (4533034)

“…</p> <p><b>Abbreviations:</b> ATG14: autophagy related 14; Baf A1: bafilomycin A₁; BARA: β-α repeated, autophagy-specific; CQ: chloroquine; GFP: green fluorescent protein; GLIPR2: GLI pathogenesis related 2; HBSS: Hanks’ balanced salt solution; KO: knockout; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PBS: phosphate-buffered saline; PtdIns3K-C1: phosphatidylinositol 3-kinase complex I; PtdIns3P: phosphatidylinositol-3-phosphate; SEM: standard error of the mean; WIPI2: WD repeat domain, phosphoinositide interacting 2</p>…”

Effects of miR162a on <i>dmTOR</i> gene expression and <i>Drosophila</i> phenotypes. by Kegan Zhu (4404883)

“…*p < 0.05; **p < 0.05; ***p < 0.001, one-way ANOVA. (<b>k</b>) Decrease in GFP levels in the egg chambers of pUbi-GFP-<i>dmTOR</i> transgenic <i>Drosophila</i> when miR162a was added to the larval diet. …”

Schematic figure of alignment by CLVs. by Arpad Safrany-Fark (15401555)

“…However, the remaining translational error caused an unexpectedly large shift in the axis of rotation (mean = 1.35 mm, SD = 0.77) with a 41.83: 1 ratio. …”

Soil Carbon and Nitrogen Changes following Afforestation of Marginal Cropland across a Precipitation Gradient in Loess Plateau of China by Ruiying Chang (332787)

“…The changes in STN and SOC showed correlated and were precipitation-dependent following afforestation, displaying a higher relative gain of SOC to STN as precipitation decreased. …”