Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer by Meiling Le (15335129)

“…Synergistic anticancer effects of combining inhibitors of these two enzymes are observed in leukemia and prostate cancer. Thus, a series of EZH2/LSD1 dual inhibitors are designed and synthesized to evaluate their anticancer activity. …”

Bimolecular Fluorescence Complementation (BiFC) assay detects APP dimers. by Raja Bhattacharyya (3359186)

“…<p>A. Fluorescence microscopy of cells transiently expressing APP C-terminal Split GFP 1–10 (APP(1–10)) and APP C-terminal split GFP 11 (APP(11)), FACS sorted for equal intensity. …”

Table_1_Dysbiosis of the Gut Microbiome Is Associated With Histopathology of Lung Cancer.DOCX by Xiong Qin (389239)

“…Lung cancer gut microbiota showed a decrease in short-chain fatty acids (SCFAs) producing and anti-inflammatory bacteria compared to healthy people, while some pathogenic bacteria such as proinflammatory or tumor-promoting bacteria were more abundant in lung cancer patients. …”

Datasheet1_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studi... by Lucie Hejnova (19676323)

“…Background<p>The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. …”

Simulation results using discrete <i>LLCL</i> filter. by Maged Al-Barashi (18721120)

“…This paper proposes a magnetic integrated inductor-trap-inductor (<i>LLCL</i>) filter to decrease the filter’s size and investigate its application in traction converters. …”

The flowchart of the study selection process. by Min Yu (120607)

“…Randomized controlled trials (RCTs) and non-randomized self-controlled trials with a treatment duration of at least 1 year with MAD were included. …”

Data_Sheet_1_The effect of cognitive reappraisal and expression suppression on sadness and the recognition of sad scenes: An event-related potential study.docx by Chunping Yan (13846756)

“…These findings suggest that down-regulation reappraisal and expression suppression can effectively decrease sadness, and that down-regulation reappraisal (relative to expression suppression) is a more effective regulation strategy for sadness. …”

Biogas Upgrading via Hydrogenotrophic Methanogenesis in Two-Stage Continuous Stirred Tank Reactors at Mesophilic and Thermophilic Conditions by Ilaria Bassani (1506502)

“…The increase of hydrogenotrophic methanogens and syntrophic <i>Desulfovibrio</i> and the decrease of aceticlastic methanogens indicate a H₂-mediated shift toward the hydrogenotrophic pathway enhancing biogas upgrading. …”

Data_Sheet_2_Effect of arsenic stress on the intestinal structural integrity and intestinal flora abundance of Cyprinus carpio.PDF by Xiaodan Shi (129498)

“…Among the top 30 harmful and beneficial bacteria, As treatment resulted in a significant (P < 0.05) increase in harmful bacteria (such as Fusobacteriota, Bacteroidota (LPS-producing bacteria), Verrucomicrobiota, Bacteroides, Aeromonas, and Stenotrophomonas) and a significant (P < 0.05) decrease in beneficial bacteria (such as Actinobacteriota, Planctomycetota, Firmicutes, Reyranella, Akkermansia, and Pseudorhodobacter), which further demonstrated that As affects the abundance of intestinal flora. …”

DataSheet_1_Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis.pdf by Xiaofang Li (212165)

“…Mechanistically, noise exposure led to a decrease in tight junction proteins in the gut and hippocampus and an increase in serum inflammatory mediators, which were significantly alleviated by Lactobacillus rhamnosus GG intervention.…”

DataSheet2_Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.docx by Yuandong Shao (13776838)

“…We found that ICA treatment inhibited the chondrocytes apoptosis and the decrease of extracellular matrix production in a dose-dependent manner. …”

Image_4_Impact of Prebiotic β-glucan Treatment at Juvenile Age on the Gut Microbiota Composition and the Eventual Type 1 Diabetes Onset in Non-obese Diabetic Mice.TIF by Harrison B. Taylor (8501220)

“…Immune phenotype of the colon showed skewing toward immune regulatory and Th17 cytokines with increases in IL-10, IL-17, and IL-21 and a decrease in TNF-α, although increases in some pro-inflammatory cytokines (IL-1b, IFN-γ) were observed. …”

Image_1_Exposure to Crude Oil and Chemical Dispersant May Impact Marine Microbial Biofilm Composition and Steel Corrosion.PDF by Jennifer L. Salerno (5344529)

“…Overall, functional gene analyses revealed a decrease in genes (predicted using PICRUSt and observed in sequenced metagenomes) associated with hydrocarbon degradation in dispersant-treated biofilms. …”

Biological Properties of Experimental Methacrylate-Based Sealers Containing Calcium Phosphates by Leticia Boldrin Mestieri (12791975)

“…In both viability assays, HAp and AHP sealers were similar, and α-TCP presented lower viability compared to the others at MTT assay (p<0.05). A gradual decrease of the inflammatory response according to the periods was observed and AHP was the only that presented giant cells (7-day period). …”

Quantitative Phosphoproteomics of Murine <i>Fmr1</i>-KO Cell Lines Provides New Insights into FMRP-Dependent Signal Transduction Mechanisms by Katarina Matic (1743595)

“…Fragile X mental retardation protein (FMRP) is an RNA-binding protein that has a major effect on neuronal protein synthesis. Transcriptional silencing of the <i>FMR1</i> gene leads to loss of FMRP and development of Fragile X syndrome (FXS), the most common known hereditary cause of intellectual impairment and autism. …”

Image_1_Iron Overload-Induced Ferroptosis Impairs Porcine Oocyte Maturation and Subsequent Embryonic Developmental Competence in vitro.TIF by Weiyi Hu (10888953)

“…At the end of the in vitro maturation (IVM) period, there was a significant decrease in the polar body (PB) extrusion rate and an increase in the percentage of abnormal oocytes in the FAC treatment groups, indicating that iron overload-induced ferroptosis may suppress the meiotic process during porcine oocyte maturation. …”

Image_2_Influence of Belowground Herbivory on the Dynamics of Root and Rhizosphere Microbial Communities.PDF by Morgane Ourry (5450048)

“…Different microbial diversities based on a common soil matrix were obtained through a removal-recolonization method. …”

Table_4_Respiratory Effects of Exposure to Traffic-Related Air Pollutants During Exercise.DOCX by Giuseppe Morici (479919)

“…Spirometric changes after exercise during exposure to particulate matter and ultrafine particles suggest a decrease in lung function, especially in patients with chronic obstructive pulmonary disease. …”

Table3_Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies.x... by Lucie Hejnova (19676323)

“…Background<p>The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. …”

Genes variable across time but not between FSHD and control form two clusters. by Shan Jiang (121292)

“…<p><b>(A)</b> Cluster 1 gene decrease during differentiation. …”