Image_5_Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cor... by Yosuke Yawata (5142431)

“…One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ-aminobutyric acid–gated chloride channel (GABA_A) receptor. …”

Image_1_Xiaochaihutang Improves the Cortical Astrocyte Edema in Thioacetamide-Induced Rat Acute Hepatic Encephalopathy by Activating NRF2 Pathway.tif by Weiyi Jia (8719173)

“…Astrocytes treated with 5 mM ammonia also showed an increase in the AQP4 protein expression but a decrease in XCHT compound serum and ammonia-induced cell edema groups. …”

DataSheet1_Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.docx by Tatiana Akimova (345316)

“…In murine studies, we observed a significant inhibition of tumor growth, while 13.6% (MC38) to 22% (TC1) of tumors were completely resorbed, in conjunction with ~50% decrease of Foxp3 mRNA by qPCR and decreased numbers of intratumoral Tregs. …”

Image_3_Transcriptome analysis provides novel insights into the soil amendments induced response in continuously cropped Codonopsis tangshen.PNG by Wuxian Zhou (1598791)

“…However, the growth of C. tangshen are seriously affected by continuous cropping, which led to the decrease of the yield and quality. A field experiment was conducted to learn the effects of soil amendments on the growth of C. tangshen under continuous cropping condition, and the biological events which occurred at molecular level were investigated. …”

Table_5_On the wrong track: Sustainable and low-emission blue food diets to mitigate climate change.docx by Javier Atalah (485705)

“…For farmed species, we found a pronounced increase in the consumption of carnivorous fish and an overall decrease in low trophic-level species consumption, such as bivalves. …”

Table 1_Lactiplantibacillus plantarum L47 and inulin affect colon and liver inflammation in piglets challenged by enterotoxigenic Escherichia coli through regulating gut microbiota... by Jingna Miao (20345025)

“…</p>Results and discussion<p>CLN alleviated colon damage caused by ETEC challenge, as evidenced by an increase of colonic crypt depth, mRNA expression of tight junction Claudin-1 and Occludin, GPX activity, the concentration of IL-10 and sIgA (p < 0.05). Moreover, there was a decrease in MDA activity, the load of E. coli, the concentration of LPS, gene expression of TLR4, and the concentration of TNF-α and IL-6 (p < 0.05) in colonic mucosa. …”

Image_1_The Active Sulfate-Reducing Microbial Community in Littoral Sediment of Oligotrophic Lake Constance.TIF by Susanne Wörner (6328553)

“…^-1 and was paralleled by a decrease of 90–100% in methanogenesis as compared to the respective methanogenic controls. …”

DataSheet_2_Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis.xls by Xiaoya Li (2022250)

“…Background<p>Non-alcoholic fatty liver disease (NAFLD), a metabolic disorder that develops from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), has become an epidemic of chronic liver dysfunction worldwide. …”

Table_1_Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies.docx by Lin Yang (45852)

“…Among the latter, one dietary habit showed a significant association with cancer even after FDR correction, indicating a potential causal relationship. …”

Arginine 58 is indispensable for proper function of the <i>Francisella tularensis</i> subsp. <i>holarctica</i> FSC200 HU protein, and its substitution alters virulence and mediates... by Pavla Pavlik (13953195)

“…<p>HU protein, a member of the nucleoid-associated group of proteins, is an important transcription factor in bacteria, including in the dangerous human pathogen <i>Francisella tularensis</i>. …”

Image_4_Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cor... by Yosuke Yawata (5142431)

“…One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ-aminobutyric acid–gated chloride channel (GABA_A) receptor. …”

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease by Rian M. Nijmeijer (208613)

“…</p> <h3>Results</h3><p>mRNA expression of <em>SHP</em> in the ileum is reduced in patients with Crohn's colitis but not in patients with UC compared to controls. mRNA expression of villus marker <em>Villin</em> was correlated with <em>FXR</em> and <em>SHP</em> in healthy controls, a correlation that was weaker in UC patients and absent in CD patients. …”

Table_2_Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.xlsx by Tianmeng Yan (16682754)

“…</p>Objective<p>We evaluated the efficiency and safety of dupilumab on BP treatment and explored a mode of drug action in depth.</p>Methods and results<p>A multicenter retrospective cohort included 20 BP patients who received dupilumab with or without systemic corticosteroid in dupilumab group, and 20 matched BP patients who received corticosteroid alone in conventional group. …”

Image_2_Amnion-Derived Mesenchymal Stem Cell Exosomes-Mediated Autophagy Promotes the Survival of Trophoblasts Under Hypoxia Through mTOR Pathway by the Downregulation of EZH2.TIF by Yijing Chu (6841025)

“…Importantly, when EZH2 was overexpressed in trophoblasts treated with PQR620, a specific mTOR signaling inhibitor, the autophagy and proliferation in trophoblasts were decreased. …”

Data Sheet 1_Study on the mechanism of exogenous CaCl2 regulating cell growth and development to alleviate salt tolerance of alfalfa (Medicago sativa).pdf by Huhu Liu (11207865)

“…Calcium Chloride (CaCl₂) plays a role in signal transduction and stabilizing cell membrane system in plant response to salt stress. …”

image1_Accelerating Urban Heating Under Land-Cover and Climate Change Scenarios in Indonesia: Application of the Universal Thermal Climate Index.tif by Martiwi Diah Setiawati (10743468)

“…Under climate change scenarios, all three cities will experience increase of the heat, whereas applying the land-cover scenario demonstrated that in only Medan and Denpasar, the UTCI is likely to experience a higher increase by 3.1°C; however, in Surabaya, the UTCI will experience 0.84°C decrease in the period 2018–2042 due to urban greening. …”

Table_4_IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages.xlsx by Jan Ackermann (18067144)

“…</p>Results<p>Obese Il6ra^Δmyel mice exhibited no differences in insulin sensitivity or histological markers of AT inflammation. Notably, we found a reduction of ATMs expressing the mannose receptor 1 (CD206), as well as a decrease of the proliferation marker Ki67 in ATMs of Il6ra^Δmyel mice. …”

Table_3_Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.xlsx by Tianmeng Yan (16682754)

“…</p>Objective<p>We evaluated the efficiency and safety of dupilumab on BP treatment and explored a mode of drug action in depth.</p>Methods and results<p>A multicenter retrospective cohort included 20 BP patients who received dupilumab with or without systemic corticosteroid in dupilumab group, and 20 matched BP patients who received corticosteroid alone in conventional group. …”

Data_Sheet_1_Bumblebee Behavior on Flowers, but Not Initial Attraction, Is Altered by Short-Term Drought Stress.docx by Rebecca J. Höfer (9977432)

“…Bumblebee behavior differed between floral trait expressions, mostly independently of treatment, with larger inflorescences and flowers leading to a decrease in the time until the first flower visit and an increase in the number of visits and the flower visitation rate. …”

Table_1_Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.docx by Marko Tijardović (8160858)

“…Following the end of the recovery period IgG N-glycosylation profiles showed anti-inflammatory changes in RST group compared to the control group, which manifested as a decrease in agalactosylated (p = 0.0473) and an increase in digalactosylated (p = 0.0473), and monosialylated (p = 0.0339) N-glycans. …”