Image2_Two HCN4 Channels Play Functional Roles in the Zebrafish Heart.TIF by Jiaying Liu (2371606)

“…Finally, we knocked down the HCN4 genes using antisense morpholino and found that knocking down either or both of the HCN4 channels caused a temporal decrease in heart rate and tended to cause pericardial edema. …”

Assessment of <i>LINC-PINT</i> genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population by Ruisha Tu (17538040)

“…Rs16873842 was related to a decreased risk of ESCC in males (OR 0.70, <i>p</i> = 0.015). …”

Table6_Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pa... by David Muñoz-Herrera (14266279)

“…<p>Ca_Vγ₂ (Stargazin or TARPγ₂) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca²⁺ channels (Ca_V) and which is now known to promote the trafficking of the postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPAR) towards the cell membrane. …”

THAP11_F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation by Harmonie Dehaene (8250486)

“…In particular, THAP11_F80L exhibited a strong effect on association with the <i>MMACHC</i> promoter and led to a decrease in <i>MMACHC</i> gene transcription, suggesting that the THAP11_F80L mutation is directly responsible for the observed cobalamin disorder.…”

S5 Dataset - by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”

Superstable Cs<i>_x</i>SnBr_<i>x</i>+2@CsBr Nanocrystals with Over 1200 h of Half-Value PLQY in Air by Shuang Yang (64650)

“…The measured lifetime of PLQY decrease to half of the initial value is ∼1287 h under ambient conditions and ∼2200 h under a nitrogen atmosphere, respectively. …”

Image_2_Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.tif by Sabah Akhtar (5809925)

“…SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. …”

DataSheet1_Effects of pharmacogenomics-guided treatment on medication adherence and the antidepressant switching rate in major depressive disorder.docx by Chaoli Chen (20359785)

“…Background<p>In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system.…”

Image_3_The effect of multiple outgrowths from bronchial tissue explants on progenitor/stem cell number in primary bronchial epithelial cell cultures from smokers and patients with... by Nuray Bostancieri (17143030)

“…In parallel experiments, outgrowing cells from explants were counted after 4wks, and explants subsequently transferred to obtain new cultures for a further 3 times.</p>Results<p>As the transfer number advanced, CK5, CK14 and p63 expression was decreased in both explants and BEC from both smokers without COPD and patients with COPD, with a more pronounced decrease in BEC numbers in the COPD group. …”

Table_7_Molecular Mechanisms of Tungsten Toxicity Differ for Glycine max Depending on Nitrogen Regime.xlsx by Julian Preiner (5214974)

“…Taken together this indicates that, in contrast to the reported direct inhibition of NR, N₂ fixation appears to be indirectly inhibited by a decrease in nitrogenase synthesis due to W induced changes in nodule oxygen levels of N fix plants. …”

DataSheet1_Dose Optimization of Aditoprim-Sulfamethoxazole Combinations Against Trueperella pyogenes From Patients With Clinical Endometritis by Using Semi-mechanistic PK/PD Model.... by Muhammad Kashif Maan (5155973)

“…In the in vitro PK/PD model, the dosage proportion of sulfamethoxazole 4 mg/ml twice a day in combination with steady-state aditoprim 1 mg/ml efficiently repressed the growth of bacteria in 24 h with the ratio of 2-log10 decrease, related to the early inoculum against three T. …”

Spry1 Is Expressed in Hemangioblasts and Negatively Regulates Primitive Hematopoiesis and Endothelial Cell Function by Xuehui Yang (225729)

“…Compared to controls, <em>Spry1;Tie2-Cre</em> embryos also show a decrease in proliferation and an increase in apoptosis. …”

Epigenetic Modulations in Activated Cells Early after HIV-1 Infection and Their Possible Functional Consequences by Juliana T. Maricato (295063)

“…In addition, activated cells infected by HIV-1 showed lower CD69 expression and a decrease of IL-2, IFN-γ and metabolism-related factors transcripts indicating a possible functional consequence towards global transcriptional repression found in HIV-1 infected cells. …”

Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria by Sean M. Bell (3830008)

“…<div><p>Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). …”

Presentation_1_Maternal low-protein diet reduces skeletal muscle protein synthesis and mass via Akt-mTOR pathway in adult rats.pdf by Diogo Antonio Alves de Vasconcelos (13520896)

“…These metabolic changes were associated with a decrease in Akt and GSK-3β signaling responses to insulin and a reduction in RPS6 in the absence of the hormone. …”

Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles by Rajasekharreddy Pala (1778128)

“…Hypertension in PKD is a ciliopathy, an abnormal function and/or structure of primary cilia. …”

DataSheet_1_Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2.docx by Feyza Gül Özbay Kurt (13946325)

“…Although the level of antibodies and frequency of virus-specific T cells reduced 4-6 months after the 2^nd dose, they were augmented after the 3^rd dose followed by a decrease later. Importantly, T cells generated after the 3^rd vaccination were also reactive against Omicron variant, indicated by a similar level of IFN-γ production after stimulation with Omicron peptides. …”

DataSheet_1_Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy.docx by Astrid Z. Johansen (14771341)

“…</p>Results<p>Elevated baseline plasma YKL-40 was an independent predictor of shorter overall survival (OS) (HR 2.19, 95% CI 1.21–3.95). A ≥ 40% decrease in plasma YKL-40 during treatment was associated with longer progression-free survival (p = 0.009) and OS (p = 0.0028). …”

Image_2_Real clinical experience after one year of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease.JPEG by Javier Naranjo (13879235)

“…TV reduces eGFR in the first month without showing further changes during the first year of treatment. Patients with a higher starting eGFR will suffer a greater initial drop, with a longer recovery. …”

Stable swimming of wildtype. by Shinichi Chisada (15354141)

“…Our results revealed that the medaka <i>rad50</i> mutation concurrently reproduced tumorigenesis (8 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka), had a decrease in median survival time (65.7 ± 1.1 weeks in control vs. 54.2 ± 2.6 weeks in <i>rad50</i>^<i>Δ2/+</i> medaka, <i>p</i> = 0.001, Welch’s <i>t</i>-test), exhibited semi-lethality in <i>rad50</i>^{<i>Δ2/Δ2</i>} medaka and most of the major ataxia-telangiectasia phenotypes, including ataxia (rheotaxis ability was lower in <i>rad50</i>^<i>Δ2/+</i> medaka than in the control, Mann–Whitney U test, <i>p</i> < 0.05), and telangiectasia (6 out of 10 <i>rad50</i>^<i>Δ2/+</i> medaka). …”