Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease by Rian M. Nijmeijer (208613)

“…</p> <h3>Results</h3><p>mRNA expression of <em>SHP</em> in the ileum is reduced in patients with Crohn's colitis but not in patients with UC compared to controls. mRNA expression of villus marker <em>Villin</em> was correlated with <em>FXR</em> and <em>SHP</em> in healthy controls, a correlation that was weaker in UC patients and absent in CD patients. …”

Table_2_Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.xlsx by Tianmeng Yan (16682754)

“…</p>Objective<p>We evaluated the efficiency and safety of dupilumab on BP treatment and explored a mode of drug action in depth.</p>Methods and results<p>A multicenter retrospective cohort included 20 BP patients who received dupilumab with or without systemic corticosteroid in dupilumab group, and 20 matched BP patients who received corticosteroid alone in conventional group. …”

Image_2_Amnion-Derived Mesenchymal Stem Cell Exosomes-Mediated Autophagy Promotes the Survival of Trophoblasts Under Hypoxia Through mTOR Pathway by the Downregulation of EZH2.TIF by Yijing Chu (6841025)

“…Importantly, when EZH2 was overexpressed in trophoblasts treated with PQR620, a specific mTOR signaling inhibitor, the autophagy and proliferation in trophoblasts were decreased. …”

Data Sheet 1_Study on the mechanism of exogenous CaCl2 regulating cell growth and development to alleviate salt tolerance of alfalfa (Medicago sativa).pdf by Huhu Liu (11207865)

“…Calcium Chloride (CaCl₂) plays a role in signal transduction and stabilizing cell membrane system in plant response to salt stress. …”

image1_Accelerating Urban Heating Under Land-Cover and Climate Change Scenarios in Indonesia: Application of the Universal Thermal Climate Index.tif by Martiwi Diah Setiawati (10743468)

“…Under climate change scenarios, all three cities will experience increase of the heat, whereas applying the land-cover scenario demonstrated that in only Medan and Denpasar, the UTCI is likely to experience a higher increase by 3.1°C; however, in Surabaya, the UTCI will experience 0.84°C decrease in the period 2018–2042 due to urban greening. …”

Table_4_IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages.xlsx by Jan Ackermann (18067144)

“…</p>Results<p>Obese Il6ra^Δmyel mice exhibited no differences in insulin sensitivity or histological markers of AT inflammation. Notably, we found a reduction of ATMs expressing the mannose receptor 1 (CD206), as well as a decrease of the proliferation marker Ki67 in ATMs of Il6ra^Δmyel mice. …”

Table_3_Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.xlsx by Tianmeng Yan (16682754)

“…</p>Objective<p>We evaluated the efficiency and safety of dupilumab on BP treatment and explored a mode of drug action in depth.</p>Methods and results<p>A multicenter retrospective cohort included 20 BP patients who received dupilumab with or without systemic corticosteroid in dupilumab group, and 20 matched BP patients who received corticosteroid alone in conventional group. …”

Data_Sheet_1_Bumblebee Behavior on Flowers, but Not Initial Attraction, Is Altered by Short-Term Drought Stress.docx by Rebecca J. Höfer (9977432)

“…Bumblebee behavior differed between floral trait expressions, mostly independently of treatment, with larger inflorescences and flowers leading to a decrease in the time until the first flower visit and an increase in the number of visits and the flower visitation rate. …”

Table_1_Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.docx by Marko Tijardović (8160858)

“…Following the end of the recovery period IgG N-glycosylation profiles showed anti-inflammatory changes in RST group compared to the control group, which manifested as a decrease in agalactosylated (p = 0.0473) and an increase in digalactosylated (p = 0.0473), and monosialylated (p = 0.0339) N-glycans. …”

Image_3_Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer.tif by Zhixing Hao (11957489)

“…This dysregulation was characterized by a significant decrease in total lymphocytes, T cells, quiescent T cells, CD4+ T cells, and NKT cells. …”

BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline by Ana Carolina R. de Oliveira (6097307)

“…<div><p>ABSTRACT Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. …”

Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications by Kun Fang (619812)

“…Diacrylated Pluronic F127 micelles were used as a macro-cross-linker of the hydrogel and loaded with hydrophobic antimicrobial drugs. …”

Image_4_Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis.tif by Xiaoya Li (2022250)

“…Background<p>Non-alcoholic fatty liver disease (NAFLD), a metabolic disorder that develops from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), has become an epidemic of chronic liver dysfunction worldwide. …”

Inflammatory Responses Are Not Sufficient to Cause Delayed Neuronal Death in ATP-Induced Acute Brain Injury by Hey-Kyeong Jeong (238498)

“…Interestingly, neither activated microglia nor monocytes expressed iNOS, a major neurotoxic inflammatory mediator. Monocytes rather expressed CD68, a marker of phagocytic activity. …”

Data_Sheet_1_Peptidoglycan Endopeptidase Spr of Uropathogenic Escherichia coli Contributes to Kidney Infections and Competitive Fitness During Bladder Colonization.pdf by Wen-Chun Huang (8222559)

“…In the present study, we found that Spr deficiency attenuated the ability of UPEC to infect kidneys and induced a fitness defect during bladder colonization in a mouse model of UTI. …”

Data_Sheet_1_Brassinosteroid biosynthesis gene OsD2 is associated with low-temperature germinability in rice.docx by Sun Ha Kim (8958371)

“…., overexpression (OsD2-OE) and knockdown (OsD2-KD) mutants of OsD2, with the Dongjin genetic background. OsD2-KD plants showed a decrease in LTG and grain size. In contrast, OsD2-OE plants showed an increase in grain size and LTG. …”

The <i>C</i>. <i>elegans</i> Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity by Ambrose R. Kidd III (775104)

“…We performed developmental genetic analysis of the single <i>Caenorhabditis elegans</i> ortholog of Chp and Wrch, CHW-1. Using a transgenic assay of the distal tip cell migration, we found that wild-type CHW-1 is likely to be partially constitutively active and that we can alter ectopic CHW-1-dependent migration phenotypes with mutations predicted to increase or decrease intrinsic GTP hydrolysis rate. …”

Image_1_Overexpression of Tobacco GCN2 Stimulates Multiple Physiological Changes Associated With Stress Tolerance.TIF by Ning Li (45258)

“…The content of total soluble sugars and reducing sugars were decreased, whereas those of chlorophyll a and b were increased in the GCN2 overexpressing plants. …”

Image 4_Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.pdf by Youyi Wu (20786402)

“…Si-CHMP7 transfection led to a decrease in tumor cell migration, invasion, and proliferation, accompanied by an accelerated apoptotic process.…”

<strong>Insulin Sensitivity and Beta-Cell Function During Early and Late Pregnancy in Women with and without Gestational Diabetes Mellitus</strong> by Bettina Mittendorfer (88840)

“…A receiver-operating-curve analysis showed both fasting plasma glucose and 1-hour OGTT glucose at 15 weeks are predictors of GDM, but the predictive power was <30%.…”