microRNA expression in vaginal melanoma. by Mallory J. DiVincenzo (11372420)

“…<p>(A) Volcano plot of microRNAs in formalin fixed, paraffin embedded tissue from vaginal melanoma (n = 6) relative to paired normal vaginal mucosa (n = 6), determined by NanoString (minimum 2-fold change, p-value <0.01). miRs with differential expression between groups deemed significant are displayed in red according to the log₂ of the fold change in expression (x) and log₁₀ of the p-value (y). miRs in black demonstrated non-significant differential expression between groups (n = 6). …”

microRNA expression patterns in vulvar melanoma. by Mallory J. DiVincenzo (11372420)

“…<p>(A) Volcano plot of microRNAs in formalin fixed, paraffin embedded tissue from vulvar melanoma (n = 22) relative to primary cutaneous melanoma (n = 9) determined by NanoString (minimum 2-fold change, p-value <0.01). miRs with differential expression between groups deemed significant are displayed in red according to the log₂ of the fold change in expression (x) and log₁₀ of the p-value (y). miRs in black demonstrated non-significant differential expression between groups. …”

Differentially expressed genes are targets of multiple dysregulated miRs and hold negative correlations in expression across vaginal melanoma tissue samples. by Mallory J. DiVincenzo (11372420)

“…<p>(A, B) microRNA-gene target interaction networks demonstrate which differentially expressed genes in vaginal melanoma are common validated target genes for two or more differentially expressed microRNAs in vaginal melanoma. …”

Biomarker performance in low-dose mitomycin-C (MMC)-induced senescent HTFs. by Le-Tien Lin (6264473)

“…(F) The transcript levels of the <i>COL1A1</i> gene decreased in senescent HTFs and measured using qRT-PCR. …”

Typical results from a sympathetic efferent and a primary afferent. by Matthias Ringkamp (253465)

“…<p><b>A) Sympathetic efferent fiber exhibiting speeding of conduction to twin-pulse stimulation.…”

Primers for mRNA expression analysis in qPCR. by Baoai Wu (22608271)

“…Live morphology showed that treadmill exercise intervention for 8 weeks reduced high-fat diet-induced liver steatosis in mice. 8-week treadmill exercise directly decreased mir-34a expression of mice in HFD group, confirmed in OE group. …”

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung C... by Kuojun Zhang (10339222)

“…In particular, compound <b>10d</b> is an excellent NQO1 substrate that is processed faster than TSA by NQO1 and exhibited a slightly decreased NAMPT inhibitory potency than that of FK866. …”

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung C... by Kuojun Zhang (10339222)

“…In particular, compound <b>10d</b> is an excellent NQO1 substrate that is processed faster than TSA by NQO1 and exhibited a slightly decreased NAMPT inhibitory potency than that of FK866. …”

Original data. by Baoai Wu (22608271)

“…Live morphology showed that treadmill exercise intervention for 8 weeks reduced high-fat diet-induced liver steatosis in mice. 8-week treadmill exercise directly decreased mir-34a expression of mice in HFD group, confirmed in OE group. …”

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung C... by Kuojun Zhang (10339222)

“…In particular, compound <b>10d</b> is an excellent NQO1 substrate that is processed faster than TSA by NQO1 and exhibited a slightly decreased NAMPT inhibitory potency than that of FK866. …”

Stance linearity, interleg coordination parameters and summary of kinematic effects under different load conditions. by César S. Mendes (650719)

“…(A) Stance Linearity Index. Flies bearing intermediate weights show less wobble during stance phases compared to controls at 2 hours, while flies bearing the heaviest loads display more wobble at all time points. …”

Enzyme Active Site Loop Revealed as a Gatekeeper for Cofactor Flip by Targeted Molecular Dynamics Simulations and FRET-Based Kinetics by Sophie Rahuel-Clermont (6235601)

“…To monitor cofactor movements within the active site, we used an intrinsic fluorescence resonance energy transfer signal between Trp177 and the reduced nicotinamide moiety to kinetically track the flip during the catalytic cycle of retinal dehydrogenase 2 (ALDH1A2). Decreasing loop flexibility by substituting Ala for Gly271 drastically reduced the rate constant associated with this movement that became rate-limiting. …”

The I827K substitution destabilizes the 3D fold of E6AP^C-lobe (residues 761–875). by Steven A. Beasley (9099461)

“…<p>(A) The assigned ¹H-¹⁵N-HSQC spectrum of 3.5 mM human E6AP catalytic C-lobe (residues 761–875) using the one-letter amino acid code and residue number according to the human E6AP sequence. …”

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip by Sudhir P. Deosarkar (824565)

“…<div><p>Studies of neonatal neural pathologies and development of appropriate therapeutics are hampered by a lack of relevant <i>in vitro</i> models of neonatal blood-brain barrier (BBB). …”

Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin‑4 Using Quantitative SILAC-Based Proteomics by Malwina Michalak (505581)

“…The strongest induction was found for CALB2 (calretinin; ∼24-fold), TGM2 (protein-glutamine γ-glutamyltransferase 2; ∼11-fold), S100A3 (∼10-fold), and GSN (gelsolin; 9.5-fold), and the most pronounced decreases were seen for CDKN2A (tumor suppressor ARF; ∼6-fold), EPCAM (epithelial cell adhesion molecule; ∼6-fold), UBE2C (ubiquitin-conjugating enzyme E2 C; ∼5-fold), KIF2C (kinesin-like protein KIF2C; 5-fold), and LMNB1 (lamin-B1; ∼5-fold). …”

Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin‑4 Using Quantitative SILAC-Based Proteomics by Malwina Michalak (505581)

“…The strongest induction was found for CALB2 (calretinin; ∼24-fold), TGM2 (protein-glutamine γ-glutamyltransferase 2; ∼11-fold), S100A3 (∼10-fold), and GSN (gelsolin; 9.5-fold), and the most pronounced decreases were seen for CDKN2A (tumor suppressor ARF; ∼6-fold), EPCAM (epithelial cell adhesion molecule; ∼6-fold), UBE2C (ubiquitin-conjugating enzyme E2 C; ∼5-fold), KIF2C (kinesin-like protein KIF2C; 5-fold), and LMNB1 (lamin-B1; ∼5-fold). …”

DataSheet_1_Vitamin A deficiency and vitamin A supplementation affect innate and T cell immune responses to rotavirus A infection in a conventional sow model.docx by Juliet Chepngeno (7532261)

“…<p>Rotavirus A (RVA) causes ~200,000 diarrheal deaths annually in children <5yrs, mostly in low- and middle-income countries. …”

Mechanistic studies of DepR in regulating FK228 biosynthesis in <i>Chromobacterium violaceum</i> no. 968 by Yongjian Qiao (5122259)

“…C199X point mutations that locked DepR in a reduced conformation decreased the DNA-binding affinity of DepR; T232A or R278A mutation also had a negative impact on DNA binding of DepR. …”

Effect of pre-mir-21 overexpression in A2780 cells. by Ileabett M. Echevarría-Vargas (568974)

“…(<b>B</b>) Western blot analysis shows a decreased expression of PDCD4 levels in A2780-miR-21 compared with A2780-EV cells. …”

Quantification of nucleotide induced structural changes within dimeric GyrB43. by Frédéric V. Stanger (585551)

“…The changes have been calculated relative to the AMPPNP complex structure, green bars indicate an increase in distance, red bar indicate a decrease. (b) Cartoon representation of dimeric GyrB43 (ADP⋅P_i state) with the residues used for the calculations in (a) indicated. …”