DataSheet_3_Case report: biallelic DNMT3A mutations in acute myeloid leukemia.pdf by Cosimo Cumbo (3564065)

“…A 56-year-old Caucasian male with a diagnosis of AML not otherwise specified (NOS) presented a complex DNMT3A molecular profile consisting of four different somatic variants mapping on different alleles (in trans). 3D modelling analysis predicted the effect of the DNMT3A mutational status, showing that all the investigated mutations decreased or abolished DNMT3A activity. …”

Table_4_Case report: biallelic DNMT3A mutations in acute myeloid leukemia.xlsx by Cosimo Cumbo (3564065)

“…A 56-year-old Caucasian male with a diagnosis of AML not otherwise specified (NOS) presented a complex DNMT3A molecular profile consisting of four different somatic variants mapping on different alleles (in trans). 3D modelling analysis predicted the effect of the DNMT3A mutational status, showing that all the investigated mutations decreased or abolished DNMT3A activity. …”

Expressed A-p50 exhibits biological activity in A549 cells by Jing Mi (18654)

“…Co-transfection of A-p50 expression plasmid and pNF-κB-hrGFP results in a decrease in hrGFP expression (right panel). …”

Image_1_Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.TIF by Philine Marchetta (8692149)

“…OHCs in these frequency regions in young GC-A knockout mice exhibited diminished levels of KCNQ4 expression, which is the dominant K⁺ channel in OHCs, and decreased activation of poly (ADP-ribose) polymerase-1, an enzyme involved in DNA repair. …”

Image_1_Combined treatment with epigenetic agents enhances anti-tumor activity of MAGE-D4 peptide-specific T cells by upregulating the MAGE-D4 expression in glioma.tif by Shui-Qing Bi (13191738)

“…Objective<p>The study evaluated the efficacy of combined epigenetic drugs of decitabine (DAC), valproic acid (VPA), and trichostatin A (TSA) on immunotherapy against glioma.</p>Methods<p>The expression and prognosis of MAGE-D4 in glioma were analyzed online, and the expression of MAGE-D4 and HLA-A2 in glioma induced by epigenetic drugs was detected by qRT-PCR, Western blot, and flow cytometry. …”

DataSheet_1_Combined treatment with epigenetic agents enhances anti-tumor activity of MAGE-D4 peptide-specific T cells by upregulating the MAGE-D4 expression in glioma.docx by Shui-Qing Bi (13191738)

“…Objective<p>The study evaluated the efficacy of combined epigenetic drugs of decitabine (DAC), valproic acid (VPA), and trichostatin A (TSA) on immunotherapy against glioma.</p>Methods<p>The expression and prognosis of MAGE-D4 in glioma were analyzed online, and the expression of MAGE-D4 and HLA-A2 in glioma induced by epigenetic drugs was detected by qRT-PCR, Western blot, and flow cytometry. …”

Table4_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.XLSX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Table3_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.XLSX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Table6_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.XLSX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Data_Sheet_1_Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactio... by Dasiel O. Borroto-Escuela (5157557)

“…<p>Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administration. …”

Table1_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.DOCX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Table2_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.XLSX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Table5_RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma.XLSX by Cong Xu (203537)

“…<p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma with an increased tendency to relapse or refractoriness. RAB39B, a member of the Ras-oncogene superfamily, is associated with a variety of tumors. …”

Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1^G93A astrocytes by Veronica Granatiero (10339456)

“…These results suggest that modulation of astrocytic IGF1R-MTOR pathway could be a viable therapeutic strategy in SOD1 ALS and potentially other neurological diseases.…”

DataSheet1_P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7.pdf by Zhuoqi Li (8504970)

“…<p>Background: It is well known that P16^INK4A, P14^ARF, P15^INK4B mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. …”

DataSheet1_P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7.pdf by Zhuoqi Li (8504970)

“…<p>Background: It is well known that P16^INK4A, P14^ARF, P15^INK4B mRNAs, and ANRIL lncRNA are transcribed from the CDKN2A/2B locus. …”

Two bortezomib injections do not improve muscle morphology, reduce fibrosis or increase body weight in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice. by Zandra Körner (843029)

“…<p>(A) The shift in fiber-size distribution was not affected by administration of bortezomib to <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice. …”

The association between alcohol intake and the risk of incident proteinuria and low estimated glomerular filtration rate (eGFR) in various subgroups. by Minseon Park (560563)

“…Incident proteinuria was defined as 1+ or higher spot urine dipstick test for proteinuria in the participants who showed a negative dipstick test at baseline. Incident low eGFR was defined as a decrease in eGFR <60 mL/min per 1.73 m² in the participants who had eGFR ≥60 mL/min per 1.73 m² at baseline. eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine level. …”

The effect of CWI on (A) creatinine levels, (B) estimated glomerular filtration rate (eGFR) and correlations between these parameters before (C) and after (D) CWI in young healthy... by Aneta Teległów (9570190)

Effect of low oxygen on proliferation and p53 levels. by Larisa Pereboeva (322533)