A prospective study of the factors associated with life quality during medical internship by Yu-Hsuan Lin (64104)

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…The proteasome is receiving attention as a potential drug target for treatment of a variety of infectious parasitic diseases, but it has been understudied in the schistosome. …”

Statins and Hip Fracture Prevention – A Population Based Cohort Study in Women by Arja Helin-Salmivaara (123653)

“…In the hypertension and the population cohorts, the rates were 2.0 per 1000 py (312 fractures per 157 090 py) and 1.0 per 1000 py (212 fractures per 216 329 py), respectively. Adjusting for a propensity score and individual variables strongly predicting the outcome, good adherence to statins for five years was associated with a 29% decreased risk (HR 0.71; 95% CI 0.58–0.86) of a low-energy hip fracture in comparison with adherent use of hypertension drugs. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…The proteasome is receiving attention as a potential drug target for treatment of a variety of infectious parasitic diseases, but it has been understudied in the schistosome. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…The proteasome is receiving attention as a potential drug target for treatment of a variety of infectious parasitic diseases, but it has been understudied in the schistosome. …”

Withanolide A Prevents Neurodegeneration by Modulating Hippocampal Glutathione Biosynthesis during Hypoxia by Iswar Baitharu (414359)

“…Supplementation of withanolide A during hypoxic exposure increased GSH level, augmented GSH dependent free radicals scavenging system and decreased the number of caspase and hoescht positive cells in hippocampus. …”

Pyrvinium inhibits WNT signaling in a CK1α dependent manner. by Bin Li (39349)

“…<p><b>A</b>. The expression of the WNT target gene: <i>AXIN2</i> was determined from NIH 3T3 cells expressing control or <i>CK1α</i>-specific shRNAs. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…The proteasome is receiving attention as a potential drug target for treatment of a variety of infectious parasitic diseases, but it has been understudied in the schistosome. …”

Data_Sheet_1_Suppression of the Lycopene Cyclase Gene Causes Downregulation of Ascorbate Peroxidase Activity and Decreased Glutathione Pool Size, Leading to H2O2 Accumulation in Eu... by Shun Tamaki (3796507)

“…In the present study, we identified an uncharacterized gene encoding the E. gracilis β-carotene synthetic enzyme lycopene cyclase (EgLCY) and discovered a relationship between EgLCY-mediated carotenoid synthesis and the reactive oxygen species (ROS) scavenging system ascorbate-glutathione cycle. …”

Anatomical connectivity matrix and resulting functional connectivities as a function of delay distribution. by Robert Ton (606974)

“…<p><b>A</b>: Sparse neuroanatomical coupling matrix serving as structural connectivity (connections are given in yellow). …”

Telomestatin induces a delocalization of Topo III from PML and TRF2. by Nassima Temime-Smaali (260017)

“…<p>Representative images are of untreated MRC5-V1/YFP-Topo III cells or cells treated for 48 h with 2 µM telomestatin. A, Topo III detected by fluorescence of YFP-tagged Topo III (green) and PML detected by immunofluorescence (red). …”

Dynamic variations of cell populations given distinct Aβ removal rate. by Ishwar K. Puri (358815)

“…<p>Variations in the (a) M₁, (b) A_p, (c) Aβ, and (d) N_d populations over 20 years for three values of α_r  =  1× (black), 10⁻¹× (red), and 10⁻²× (blue) the value reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015176#pone-0015176-t001" target="_blank">Table 1</a> for the Aβ removal rate. …”

Mutational pathways to a novel function when function and stability trade-off. by Kuo Hao Lee (203310)

“…<p>(A) Dashed line: mutation 1 on the ancestral background confers increase in novel function, but stability is decreased. …”

Theoretical expectations of differences in contagion between central individuals and the population as a whole. by Nicholas A. Christakis (155218)

“…<p>A contagious process passes through two phases, one in which the number of infected individuals exponentially increases as the contagion spreads, and one in which incidence exponentially decreases as susceptible individuals become increasingly scarce. …”

A, B. Effects on explicit instruction about prospects of alternative goals on behavior. by Sneha Aenugu (21364349)

“…<p><b>A.</b> Task performance improves with instructions yet significantly falls short of the optimal prospective agent. …”

Distribution of gene expression (A) and tags (B) between experimental and control groups. by Fengguang Pan (111458)

“…<p>Panel A represented the distribution of gene expression in the H37Rv-treated library (A1), BCG-treated library (A2), and control library (A3). …”

Size matters: A schematic of the hypothesised effect of network size on resonance frequency. by Caroline A. Lea-Carnall (2512003)

“…One method to probe the resonance properties is to drive the networks with repetitive, periodic stimuli over a range of frequencies (<i>f1 < f2 < f3</i>). For each network, the driving frequency corresponding to the maximal response power is deemed to be closest to the resonance frequency of that network. …”

Peak enhancement in control (A, C) and pilocarpine-treated animals (B, D). by Paolo Francesco Fabene (80996)

“…<p>Compared to controls, in rats during SE, sub-granular layers showed a decreased contrast medium peak concentration (D, blue dots), indicating a relative ischemic core, whereas supra-granular layers were characterized by hyperemia (D, red dots). …”

Representative EMG amplitude data from two subjects (A and B respectively). by Leonardo Gizzi (390922)

“…For instance, the right upper trapezius (RUTR) shows reduced activity in the painful condition for Subject A but increased activity for subject B. (Right–R and Left–L: Sterno Hyoideus–HYO, Sternocleidomastoideus-STER, Anterior Scalenus-SCA, Splenius Capitis–SPL, Upper trapezius-UTR, Lower Trapezius-LTR).…”

PBM induces focal activation of microglial phagocytosis around Aβ plaques. by Kevin J. Johnson (2647639)

“…</b> Quantitative analysis of total and activated microglia show no overall differences in the neuroinflammatory environment surrounding Aβ plaques. (Unpaired t-test). <b>C.</b> Analysis of the distribution of CD68+ microglia shows a trend of higher concentration of phagocytic cells in contact with plaques, and decreasing phagocytosis away from plaques. …”