Optimization of a glucagon-like peptide 1 receptor antagonist antibody for treatment of hyperinsulinism by Sean M. Peterson (820405)

“…TB-222-023 effectively decreased insulin secretion in primary isolated pancreatic islets from a mouse model of hyperinsulinism, <em>Sur1</em>-/- mice, and in islets from an infant with HI as well as increased plasma glucose and decreased the insulin to glucose ratio in <em>Sur1</em>-/- mice. …”

Release of Membrane-Bound Vesicles and Inhibition of Tumor Cell Adhesion by the Peptide Neopetrosiamide A by Pamela Austin (248283)

“…</p><h3>Methodology/Principal Findings</h3><p>We show that NeoA reversibly inhibits tumor cell adhesion, disassembles focal adhesions in pre-attached cells, and decreases the level of β1 integrin subunits on the cell surface. …”

Trophozoites of <i>Gregarina cuneata</i> observed using a transmission electron microscope. by Andrea Valigurová (311983)

“…</b> Trophozoite exhibiting a quite completely decreased epimerite (asterisks) with numerous mitochondria and gradual detachment (arrowhead) from host cell (hc), membrane fusion sites (in circles), protomerite (p).…”

Acute morphine causes a dose-dependent MOR – G protein coupling switch. by Hoau-Yan Wang (39303)

“…<p>Densitometric quantitation (<i>B</i>) of blots (<i>A</i>) shows that the level of MOR–Gs coupling after 15-min morphine exposure increases progressively as dose increases from 0.1 to 100 µM concentrations. …”

(A, B) The density of Ranvier node in optic disc is not influenced by optic nerve injury. by Suqi Zou (379705)

Postpolicy changes in county-level vaccination coverage and exemptions as a function of prepolicy prevalence. by Sindiso Nyathi (8173356)

Slowing AiiA production in Eqs (1)–(4) leads to oscillations and Turing patterns. by Bartłomiej Borek (1434244)

“…<p>A codimension one bifurcation of the AHL fixed point, <i>L</i>_*, losing stability through a Hopf bifurcation and into a Turing instability as Aiia production rate is decreased. …”

Persistence rates from the different studies, showing a significant trend (p 0 by J A Cramer (85897)

“…<p><b>Copyright information:</b></p><p>Taken from "The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review"</p><p></p><p>International Journal of Clinical Practice 2008;62(1):76-87.…”

A Real-Business-Cycle Model with GHH-preferences: Lessons for Bulgaria (1999-2019) by Aleksandar Vasilev (17169148)

“…The quantitative effect of such preferences is found to slightlydecrease consumption and investment volatility, which is a step in the right direction, but also decreases the variability of hours and wages relative to the standard logarithmic utility; overall, the effect is rather small though.…”

A possible mechanism for the up-regulation of NADPH oxidase activity under redox stress. by Irundika H. K. Dias (425605)

Adjustment of the off-axis angle of a blood vessel running in the X-Y plane. by Marina Garcia Garrido (128481)

“…<p>As detailed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131154#pone.0131154.g002" target="_blank">Fig 2</a>, the off-axis angle of a retinal vessel is decreased when the X/Y ratio is increased (A). …”

Time course of BD production during SSF in a 5–l stirred bioreactor. by Ailong Wang (154521)

“…The cultivation was carried out at an initial pH of 7.0. When pH decreased to 6.0, it was maintained at 6.0 in the fermentation processes by automatic addition of 4 M H₃PO₄ or 6 M KOH using a program-controlled peristaltic pump. …”

Sildenafil inhibits endothelin-induced vasoconstriction but not cellular proliferation in smooth muscle cells. a. by Yoshifumi Kawanabe (308848)

A 55-year-old man with category 3 on US and autoimmune parotitis in histopathology. by Do Hun Kim (4596913)

“…<p>On the longitudinal gray-scale sonogram (A), a benign mixed tumor (arrows) in the right parotid gland is observed, and the right parotid gland (arrowheads) shows decreased parenchymal echogenicity, coarse parenchymal echotexture, normal gland size, and a smooth margin. …”

Bovine DET1 is a direct target of the miR-155 oncomiR. by Justine Marsolier (404189)

“…<p><b>(A)</b> Luciferase reporters containing the total 3′UTR of DET1 and TP53INP1 show that Buparvaquone induced Luciferase in parasitized TBL3 cells, but not in parental BL3 cells, and Luciferase induction was lost when the miR-155 target binding site was mutated (mDet1) (average ± sd, n = 3). …”

Leprosy in elderly people and the profile of a retrospective cohort in an endemic region of the Brazilian Amazon by João Sérgio de Sousa Oliveira (7340210)

“…<div><p>Background</p><p>Leprosy has a global presence; more than 180 thousand new cases were registered in 2013, 15% of which were found in the Americas. …”

The Association between MTHFR Gene Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis by Xue Qin (123365)

“…</p> <h3>Results</h3><p>Finally, 12 studies with 2,351 cases and 4,091 controls were included for C677T polymorphism and 6 studies with 1,333 cases and 1,878 controls were included for A1298C polymorphism. With respect to A1298C polymorphism, significantly decreased HCC risk was found in the overall population (CC vs. …”

Disrupted Calcium Release as a Mechanism for Atrial Alternans Associated with Human Atrial Fibrillation by Kelly C. Chang (673320)

“…Using single-cell clamps of voltage, fluxes, and state variables, we determined that alternans onset was Ca²⁺-driven rather than voltage-driven and occurred as a result of decreased RyR inactivation which led to increased steepness of the sarcoplasmic reticulum (SR) Ca²⁺ release slope. …”

Parameter sensitivity analyses within 25% variation on default values of a specific parameter. by Puranjan Ghimire (18340529)

“…All ranges of <i>ε</i> favor the bistable state for copy number between 2 and 7, favor the silenced state for copy number 14 and above, and the range of <i>ε</i> favoring the bistable state decreases with the increase in copy number. (D) Like methylation rate, a lower value of methylation spreading rate (<i>ϕ</i>) favors bistability or desilenced state. …”

Causal Association of Galectins and Diabetic Retinopathy: A Two-Sample Mendelian Randomization Study by Shanshan Yang (423383)

“…<p>Diabetic retinopathy (DR) is a common microvascular complication of diabetes. …”