A Systems Toxicology Approach to Elucidate the Mechanisms Involved in RDX Species-Specific Sensitivity by Christopher M. Warner (2064109)

“…While the 10-fold interspecies uncertainty factor does provide a reasonable cross-species estimate of toxicity in the present study, the observation that the responses between ZF and FHM are markedly different does initiate a call for concern regarding establishment of broad ecotoxicological conclusions based on model species such as zebrafish.…”

Data_Sheet_1_Use of the word “evolution” in the time of a global pandemic.PDF by Sada M. Boyd (19238926)

“…We also found that, as the pandemic progressed, the discussion on viral evolution as a topic had increased, but the frequency with which the word “evolve” was explicitly used had decreased.…”

Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis by Fleur E. P. van Dooren (385472)

“…<div><p>Objective</p><p>To examine the association between depression and all-cause and cardiovascular mortality in people with diabetes by systematically reviewing the literature and carrying out a meta-analysis of relevant longitudinal studies.…”

Image_1_Amelioration of Endotoxemia by a Synthetic Analog of Omega-3 Epoxyeicosanoids.jpeg by Akira Shikuma (12130158)

“…Overall survival significantly improved following preventative EEQ-A administration along with decreased transcript level of pro-inflammatory cytokines. …”

A Novel Network Profiling Analysis Reveals System Changes in Epithelial-Mesenchymal Transition by Teppei Shimamura (133856)

“…As a result, we found that knockdown of KLF5 by siRNA significantly decreased E-cadherin expression and induced morphological changes characteristic of EMT. …”

Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation by Tadashi Miyamoto (126889)

“…These results, based on a gene regulatory network and expression dynamics, contribute to our wider understanding of pluripotency, differentiation, and reprogramming of cells, and they provide a fresh viewpoint on robustness and control during development.…”

Alignment and Analysis of a Disparately Acquired Multibatch Metabolomics Study of Maternal Pregnancy Samples by Hani Habra (10312923)

“…Measurements acquired with different LC-MS protocols or following extended time intervals harbor significant variation in retention times and spectral abundances due to altered chromatographic, spectrometric, and other factors, raising many data analysis challenges. We developed a computational workflow for merging and harmonizing metabolomics data acquired under disparate LC-MS conditions. …”

Table_1_The Spatial Signature of Introgression After a Biological Invasion With Hybridization.DOCX by Claudio S. Quilodrán (9433838)

“…Using spatially explicit simulations, we explored the spatial distribution of introgression across the area of colonization of an invasive taxon hybridizing with a local taxon. The general pattern for neutral loci supported by our results is an increasing introgression of local genes into the invasive taxon with the increase in the distance from the source of the invasion and a decreasing introgression of invasive genes into the local taxon. …”

Image_7_Amelioration of Endotoxemia by a Synthetic Analog of Omega-3 Epoxyeicosanoids.jpeg by Akira Shikuma (12130158)

“…Overall survival significantly improved following preventative EEQ-A administration along with decreased transcript level of pro-inflammatory cytokines. …”

Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile by Zhitong Jiang (9025358)

“…Furthermore, a comprehensive understanding of the specific impact of aging on PRP requires a systematic investigation. …”

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus by S.C.X. de-Almeida (6720584)

“…The objective of this study was to investigate a triterpene-rich fraction (FJNB) from H. drasticus latex on acute models of nociception and inflammation and to clarify its mechanisms of action. …”

Alignment and Analysis of a Disparately Acquired Multibatch Metabolomics Study of Maternal Pregnancy Samples by Hani Habra (10312923)

“…Measurements acquired with different LC-MS protocols or following extended time intervals harbor significant variation in retention times and spectral abundances due to altered chromatographic, spectrometric, and other factors, raising many data analysis challenges. We developed a computational workflow for merging and harmonizing metabolomics data acquired under disparate LC-MS conditions. …”

Data_Sheet_1_The chemical neighborhood of cells in a diffusion-limited system.docx by Juliana Gesztesi (15308869)

“…We determined the radius of the zone of depletion, within which cells had reduced the substrate concentration by 10%, to be 5.04 mm for an individual Escherichia coli cell in the conditions we simulated. However, we saw a synergistic effect with multiple cells near each other: multiple cells in close proximity decreased the surrounding concentration by almost 95% from the initial substrate concentration. …”

Effects of diode laser application on inflammation and mpo in periodontal tissues in a rat model by Mustafa Özay USLU (5528210)

“…The control group (n=30) received only SRP treatment, while the laser group (n=30) received a diode laser (GaAlAs, 810 nm, 1 W, 10 J, 20 s) treatment adjunctive to SRP. …”

Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model by Jeonghyun Choi (4857169)

“…The purpose of this study was to identify standard indicators of this condition by comparing clinical, pathophysiological, and neurobehavioral features in an autism-like animal model. A total of 22 male Sprague-Dawley rats were randomly divided into control and 500 mg/kg propionic acid (PPA)-treated groups. …”

Understanding Regiodivergence in a Pd(II)-Mediated Site-Selective C–H Alkynylation by Kenji Usui (1748389)

“…TIPS alkyne <i>bromides</i> react selectively with the six-membered palladacycle (from δ-palladation) through a migratory insertion pathway. The observed δ-selectivity in this case is attributed to decreased ring strain in the migratory insertion transition state with the six-membered palladacycle. …”

Innovation in a Post-Oil City: Moving Design Away from Carbon Dependency by Idrees Rasouli (22174948)

“…This has led to the development of a design mindset that prioritizes increased consumption and production, justifies resource access, and embodies a lifestyle unique to advanced societies. …”

A Comparative Analysis of Prenatal Care and Fetal Growth in Eight South American Countries by Cristina Woodhouse (534871)

“…Furthermore, as one of the indicators for a country’s healthcare system for maternal and child health, prenatal care is a highly variable indicator between countries in South America.…”

Flexible Platform Composed of T‑Shaped Micropyramid Patterns toward a Waterproof Sensing Interface by Niming Peng (17442472)

“…To improve the liquid repellency of micropyramid structures, this work presents a study of the design and fabrication of T-shaped micropyramid structures. …”

Table_1_Mutations identified in engineered Escherichia coli with a reduced genome.XLSX by Yuto Kotaka (15907688)

“…The first was an insertion at the promoter region of pntA, which increased cognate gene expression. The second was an insertion sequence (IS) present in sibE, encoding the antitoxin in a toxin-antitoxin system, which decreased expression of sibE. 5 strains of Δ37c independently isolated following ALE harboring multiple SNVs and genetic rearrangements. …”