Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment by Phung Nguyen (230474)

“…The <b>CHBC</b>–GPR17 interaction leads to a rapid decrease of cAMP and Ca²⁺. <b>CHBC</b> exhibits the cytotoxicity effect on GBM cells in a dose-dependent manner with an IC₅₀ of 85 μM, whereas the known agonist MDL29,951 showed a negligible effect. …”

Nitrogen addition increases aboveground silicon and phytolith concentrations in understory plants of a tropical forest by xiaofei Lu (11679673)

“…The significant accumulation of Si in the leaves and the unaltered plant-available Si concentrations in the soil were associated with enhanced plant Si uptake and decreased soil phytolith return due to increased phosphorus <a>(P) limitation</a>, soil acidification, and decreased leaf C:N ratios caused by N addition.…”

Social and Demographic Effects of Anthropogenic Mortality: A Test of the Compensatory Mortality Hypothesis in the Red Wolf by Amanda M. Sparkman (216713)

“…When involving the death of a breeder, anthropogenic mortality was also additive to natural rates of breeding pair dissolution, resulting in a net decrease in the annual preservation of existing breeding pairs. …”

<i>Chk1</i>+/− mice show a disruption in enucleation of erythrocytes in the bone marrow. by Nathan C. Boles (200328)

“…The P2 gated cells, the majority of which should be immature erythrocytes with their nuclei still intact show a decrease in nucleated cells with a concurrent increase in enucleated cells in the <i>Chk1+/−</i> whole bone marrow. …”

Increased Immunogenicity and Protective Efficacy of Influenza M2e Fused to a Tetramerizing Protein by Anne-Marie Carola Andersson (130612)

“…Most importantly, vaccination with M2e-NSP4 caused a significant decrease in lung virus load early after challenge with influenza A virus and maintained its efficacy against a lethal challenge even at very low vaccine doses. …”

BioMAP biomarker profiles for (A) ruxolotinib, (B) fedratinib, (C) momelotinib, and (D) pacritinib. by Jack W. Singer (3014436)

“…Biomarker key activities are described as modulated if these activities increase in some systems, but decrease in others. Cytotoxicity is indicated on the profile plot by a thin black arrow above the X-axis, and antiproliferative effects are indicated by a thick grey arrow. …”

A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal? by Giuseppe Grosso (560782)

“…We performed a meta-analysis to explore the association in prospective studies and randomized control trials (RCTs) between Mediterranean diet adherence and CVD incidence and mortality. …”

A Tale of Two Morphs: Modeling Pollen Transfer, Magic Traits, and Reproductive Isolation in Parapatry by Benjamin C. Haller (628639)

“…In a different pollination scenario, however, precise pollen transfer causes a decrease in adaptive divergence by promoting asymmetric gene flow. …”

Identification of <i>Abhd2</i> as a driver of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in liver. by Tara R. Price (16715660)

“…<p>(<b>A</b>) LOD profiles for <i>Abhd2</i> expression and abundance of several phospholipids in liver identify a common quantitative trait locus (QTL) at ~79 Mbp on chromosome 7. …”

Modulation of TLX and PNR transcriptional activities by ccrp1, ccrp2 and ccrp3. A. by Cindy Benod (579282)

“…<p>Transfections of TLX LBD repress the UAS promoter leading to a decrease in luciferase activities compared to the control (cells transfected with empty GAL4 vector). …”

Poincaré maps for the best no-FIC (A1) and post-FIC (B1) MMF fit. by Jan Stasinski (20371167)

“…A decrease in number of nodes in a single regime or an increase in the number of nodes in two or three regimes is considered a richer repertoire of behaviors as a result of implementing dFIC.…”

Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis by Ma Yubo (3966581)

“…We demonstrated that MSC treatment could significantly decrease VAS and increase IKDC scoresafter a 24-month follow-up compared with controls (<i>P</i><0.05). …”

Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator by Yi-Chieh Chang (11025999)

“…Two-phase flow separation is a key step in various downstream purification processes. …”

Incidence of lower extremity amputations in the diabetic compared with the non-diabetic population: A systematic review by Maria Narres (575779)

“…Study designs, statistical methods, definitions of major and minor amputations, as well as the methods to identify patients with diabetes differed greatly, explaining in part these considerable differences. Some studies found a decrease in incidence of LEA as well as relative risks over time. …”

Image_2_Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation.jpg by Camille Albrecht (9774560)

“…Accumulative data have shown that inhibition of neuraminidases, such as NEU1 sialidase, may be a promising pharmacological target, and selective inhibitors of NEU1 are therefore needed to better understand the biological functions of this sialidase. …”

Supplemental materials for Effects of age on human skeletal muscle: A systematic review and meta-analysis by Christopher Lee (19739632)

“…<p dir="ltr">Human studies examining the cellular mechanisms behind sarcopenia, or age-related loss of skeletal muscle mass and function, have produced inconsistent results. A systematic review and meta-analysis were performed to determine the aging effects on protein expression, size and distribution of fibers with various myosin heavy chain (MyHC) isoforms. …”

Table_1_EMDR in pediatric hospital setting: a case report of an adolescent with cancer.pdf by Sabrina Ciappina (18237379)

“…</p>Results<p>By using EMDR protocol the patient reported a decrease of emotional activation after a few EMDR sessions.…”

Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase by Safiatou T. Coulibaly (816058)

“…Importantly, a remarkable effect is also observed in treatments with the anticancer compound cytarabine (AraC), for which a 10,000 fold decrease in IC50 occurred. …”

Glycine promotes longevity in <i>Caenorhabditis elegans</i> in a methionine cycle-dependent fashion by Yasmine J. Liu (6433946)

“…In this study we show that this is coupled to a decrease in gene expression of enzymes important for glycine catabolism. …”

Effect of GluA2 RNAi on the dendritic morphology of E11 chicken lumbar motoneurons. by Yone J. Yoon (296191)

“…<p><i>A</i><b><i>–D</i></b><i>)</i> Infection of chicken embryos with the RCASBP(B)-RFP-GluA2 RNAi construct causes a significant decrease in the dendritic complexity of E11 motoneurons. …”