The effect of 25OHD3 on the expression of renal PMCA1b and NCX1 in CYP27B1^+/+ and CYP27B1^-/- mice. by Noelia Torremadé (3687523)

25OHD₃ increases expression of CalbindinD-28K in the kidneys of CYP27B1^-/- mice with CKD. by Noelia Torremadé (3687523)

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Up-regulation of miR-17-20a and 19a-19b predicted targets following Spi-1 and Fli-1 knockdown in 745A#44 cells. by Samer Kayali (133888)

“…Significant enrichments are indicated in bold. B: Mean relative expression profiles of the leading edge subsets of common predicted targets for miR-17/20a, miR-19a/19b and miR-451 identified by GSEA in response to progressive decrease of miR-17-92 expression or progressive increase of miR-451 induced by indicated combinations of HMBA and Dox treatment in 745A#44 cells.…”

Total blood cell counts are decreased in the irradiated (2 Gy) groups +/− HU treatment WBCs (A) and lymphocytes (B) at 4 days post-proton radiation exposure are significantly decreased, compared to the No treatment group (*). by Jenine K. Sanzari (306909)

“…Average counts +/− SD are expressed as a fraction of the control, n = 3–5. The neutrophil count at 4 days post-proton radiation exposure + HU treatment are significantly decreased, compared to the neutrophil counts observed for the No treatment group (*) and the HU group (#). …”

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…We added their proxy variants in LD (r² ≥ 0.8; based on 1000 genomes project data [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref050" target="_blank">50</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref051" target="_blank">51</a>]). …”

Fig 7 - by Denghui Wang (10275794)

Focal female offspring production is higher on dishes where the unrelated demonstrator originates from the same (IV) population than a different (IV-bw) population. by Emily Rakosy (20939774)

Presentation_1_Bacillus subtilis MutS Modulates RecA-Mediated DNA Strand Exchange Between Divergent DNA Sequences.pdf by Begoña Carrasco (109021)

“…We propose that MutS assists DNA strand exchange by facilitating RecA disassembly, and indirectly re-engagement with the homologous 5′-end of the linear duplex. …”

Linear predictive models show declining measures of autozygosity and F_ld. by Michael A. Nalls (113680)

“…These predictive models include decreasing (A) %ROH, (B) number of ROHs, (C) F_ld and the (D) average length of ROHs. …”

Heavy metals concentration in ammonia removal rate; as % of the source (ARRS) and ammonia removal rate; as % of the control (ARRC) of different treatments (Means± SE). by Ghada R. Sallam (18319994)

Supplementary Material for: Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy by Wang C. (2954256)

“…<b><i>Results:</i></b> GM130 expression was significantly decreased in tonsil tissues and PBMC of IgAN patients; the expression of C1GALT1 decreased and Gd-IgA1 level increased significantly in patients with IgAN patients. …”

Kat60 lacking the MIT domain or the MIT domain and linker region detectably colocalizes with only a few, if any, microtubules in cells. by Kyle D. Grode (725568)

Prediction of the effects of HNF1A missense mutations on protein stability. by Sneha P. (3926957)

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Number of intermolecular hydrogen bonds formed between the protein and DNA in the native and mutant complexes. by Sneha P. (3926957)

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Three-dimensional structure of the HNF1A protein (PDB ID-1IC8) shows the POU_H (marked in pink) and POU_S (marked in blue) domains interacting with DNA. by Sneha P. (3926957)

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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach - Fig 9 by Sneha P. (3926957)

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Docking analysis scores for native and mutant (R131W, R131Q, and R203C) complexes from the HADDOCK server. by Sneha P. (3926957)

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Free energy landscape between PC1 and PC2 of native and mutant complexes. by Sneha P. (3926957)

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Block-based RMSD analysis of the native protein-DNA complex. by Sneha P. (3926957)

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