The radius of gyration analysis of native and mutant complexes. by Sneha P. (3926957)

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Backbone RMSD graph of the native and mutant complexes. by Sneha P. (3926957)

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The ConSurf analysis. by Sneha P. (3926957)

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List of potential pathogenic HNF1A missense mutations predicted by all <i>in silico</i> prediction tools. by Sneha P. (3926957)

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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by Sneha P. (3926957)

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Variant Histone H2afv reprograms DNA methylation during early zebrafish development by Bhavani Madakashira (4570399)

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Porcupine plots of the PCA analysis depicting the movement and altitude of the C-alpha atoms throughout the 50 ns simulation in the native and mutant complexes. by Sneha P. (3926957)

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Functional validation of a miRNA-34a-TREM2–3’UTR interaction. by Surjyadipta Bhattacharjee (3181674)

“…<p><b>(A)</b> ribonucleotide sequence of the 299 nt TREM2-mRNA-3’-UTR is shown in the 5’-3’ direction; the 22 nt miRNA-34a-TREM2 3’UTR complementarity-interaction region is indicated by a black underline and the 8 nt TREM2-mRNA-3’-UTR seed sequence <b>5’-ACACUGCU-3’</b> is overlaid in yellow; a single arrowhead indicates the 5’ end of a poly A+ tail in the TREM2 mRNA (22 ‘A’ nt shown; the length of this poly A+ tail is variable); TREM2 mRNA sequence derived from NM_018965; TREM2 transcript is the major X1 variant (see also <a href="http://switchdb.switchgeargenomics.com/productinfo/id_801321/" target="_blank">http://switchdb.switchgeargenomics.com/productinfo/id_801321/</a>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a></b>); <b>(B)</b> TREM2-mRNA-3’UTR expression vector luciferase reporter assay (pLightSwitch-3’UTR; Cat#S801178; Switchgear Genomics, Palo Alto CA); in this vector, the entire 299 nucleotide TREM2 3’UTR was ligated into the unique Nhe1-Xho1 site; <b>(C)</b> control C8B4 murine microglial cells, 1 week in culture; phase contrast bright field microscopy 20x; C8B4 cells transfected with the TREM2-mRNA-3’UTR expression vector luciferase reporter were treated exogenously with miRNA-34a, a scrambled control miRNA-34a (miRNA-sc) or control miRNA-183; see references and text for further details [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref018" target="_blank">18</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref019" target="_blank">19</a>]; <b>(D)</b> compared to control, C8B4 cells transfected with a scrambled (<b>sc</b>) control pLightSwitch-3’UTR vector, the TREM2-mRNA-3‘UTR vector exhibited decreased luciferase signal to a mean of 0.16-fold of controls in the presence of miRNA-34a; this same vector exhibited no change in the presence of the control miRNA-34a-sc or miRNA-183; for each experiment (using different batches of MG cells) a control luciferase signal was generated and included separate appropriate controls with each analysis; in addition a control vector β-actin-3’UTR showed no significant effects on the relative luciferase signal yield after treatment with either miRNA-183 or miRNA-34a (data not shown); dashed horizontal line set to 1.0 for ease of comparison; N = 5; *<i>p</i><0.001 (ANOVA). …”

Temporal change and intergroup comparison of tissue area mean blur rate following eye drop administration. by Nana Takahashi (9999164)

Temporal change and intergroup comparison of vessel area mean blur rate following eye drop administration. by Nana Takahashi (9999164)

Exercise-Based Cardiac Rehabilitation Has a Strong Relationship with Mean Platelet Volume Reduction by İsmet Durmuş (10376755)

“…<p></p><p>Abstract Background Mean platelet volume (MPV), which is a simple measure of platelet activation, has recently become an interesting topic in cardiovascular research. …”

Cross-sectional area of the murine aorta linearly increases with increasing core body temperature by A. Colleen Crouch (4382188)

“…Cross-sectional area of the aorta increased significantly and linearly with temperature for all groups, but at a diminished rate for aged animals (<i>p</i> < 0.01; male and female: adult, 0.019 and 0.024 mm²/°C; aged, 0.017 and 0.011 mm²/°C). …”

The HMR C-terminus is required for HMR localization in proximity to centromeres and HP1a-bound chromatin (related to Fig 4). by Andrea Lukacs (3752956)

A pear orchard in Quillón. by Jeannette Silva-López (16541854)

Chemoresistant BCM2665 transplanted in the fat pad of SCID Beige mice responds to combination of Stat3 inhibitor+docetaxel treatment, with decrease in tumor volume and TIC markers... by Bhuvanesh Dave (147341)

“…Significant decrease in mean tumor volume was noted between vehicle and combination of C188+docetaxel, and between chemotherapy and combination treatment (p<0.05). …”

Open data. by Larissa Brazolotto Ferreira (17671168)

“…</p><p>Results</p><p>There was a significant decrease in BMD in the lumbar spine (1.107 ± 0.109 and 1.075 ± 0.112 g/cm²; <i><i>p</i></i> < 0.001), total body (1.135 ± 0.086 and 1.119 ± 0.085 g/cm²; <i><i>p</i></i> < 0.001), and total proximal femur over the six months of EBF compared to the values obtained from the same EBF group at 15 days postpartum (mean percentage decreases in BMD of −3.4 ± 3.7% (<i><i>p</i></i> < 0.001) in lumbar spine, −2.5 ± 3.4% (<i><i>p</i></i> < 0.001) in total proximal femur, and −1.7 ± 1.9% (<i><i>p</i></i> = 0.001) in total body). …”

Effect of dietary squalene supplementation on plasma parameters in male <i>Apoe</i>-deficient mice. by Clara Gabás-Rivera (613994)

Relationships between individual abundance at the elevational band level of six groups of ground-dwelling arthropods and elevation. by José D. Gilgado (9455229)

Relationships between rarefied species richness at the elevational band level of six groups of ground-dwelling arthropods and elevation. by José D. Gilgado (9455229)

Map of the four transect lines examined in the Swiss National Park and its surroundings. by José D. Gilgado (9455229)