TGF-β Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence by Qiang Zhang (45005)

“…Blockade of TGF-β signaling or ERK activation (p-ERK) was associated with a dramatic decrease in the expression of DNMT, which results in a coincident increase in the expression of TβRs. …”

Image1_Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.TIF by Yanan Fu (4422967)

“…Mechanistically, UA reduced myocardial injury by inhibiting oxidative stress (as demonstrated by a decrease of superoxide and normalization of pro- and antioxidant enzyme levels). …”

Table2_Ursolic acid reduces oxidative stress injury to ameliorate experimental autoimmune myocarditis by activating Nrf2/HO-1 signaling pathway.XLSX by Yanan Fu (4422967)

“…Mechanistically, UA reduced myocardial injury by inhibiting oxidative stress (as demonstrated by a decrease of superoxide and normalization of pro- and antioxidant enzyme levels). …”

Table1_Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions.XLSX by Marina Naval-Sanchez (6497258)

“…However, DNBSEQ-G400 data contained a significantly higher number of small, sub-nucleosomal reads (>30% increase) and a reduced number of bi-nucleosomal reads (>75% decrease), which resulted in narrower peak bases and improved peak calling, enabling the identification of 4% more differentially accessible regions between PSCs and fibroblasts. …”

MiR-150-5p retards the progression of myocardial fibrosis by targeting <i>EGR1</i> by Jie Shen (31533)

“…Human MF cells were generated via <i>Trypanosoma cruzi</i> (<i>T. cruzi)</i> infection, a mouse model of MF was generated via angiotensin II. …”

Ethnic Related Selection for an <em>ADH</em> Class I Variant within East Asia by Hui Li (32376)

“…Previous studies have shown that the <em>ADH1B*47His</em> allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele has been selected for in some East Asian populations. …”

Table_2_Description of the vaginal microbiota in nulliparous ewes during natural mating and pregnancy: preliminary signs of the male preputial microbiota modulation.DOCX by Marta Barba (383893)

“…Ewes that were diagnosed with pregnancy at Tpreg showed a decreased abundance of gram-negative bacteria such as Bacteroidales, Campylobacterales, and Enterobacteriales. …”

Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry by Xiaobin Cui (553791)

“…Furthermore, miR-203 expression showed a nearly 4.5-fold decrease in ESCC than NETs (0.206 ± 0.336 vs. 0.908 ± 1.424, <i>P</i> < 0.001) and was significantly associated with lymph node metastasis <i>(P</i> = 0.012). …”

Table_2_Porphyromonas gingivalis Induces Increases in Branched-Chain Amino Acid Levels and Exacerbates Liver Injury Through livh/livk.docx by Leng Wu (5190419)

“…Additionally, livh deletion had no effect on bacterial growth, EPS production, invasion efficiency, and in vivo colonization, whereas the Δlivk strain showed a slight decrease in invasion efficiency and in vivo colonization. …”

Image_1_The Impact of the Geometric Correction Scheme on MEG Functional Topology at Rest.TIF by Stefania Della Penna (7545071)

“…Moreover, the number of hubs decreased in the alpha and beta bands, but the centrality of some fundamental regions such as the Posterior Cingulate Cortex (PCC), Supplementary Motor Area (SMA) and Middle Prefrontal Cortex (MPFC) remained strong in all bands, associated to an increase of the Global Efficiency and a decrease of Modularity. …”

Circular_0086414 induces SPARC like 1 (<i>SPARCL1</i>) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR... by Qingfeng Jiang (9134096)

“…EC patients with low circ_0086414 expression had a poor prognosis. Increasing circ_0086414 expression led to decreased EC cell proliferation, invasion and glycolysis and increased cell apoptosis, accompanied by a decrease of N-cadherin expression and an increase of E-cadherin expression. …”

Data_Sheet_1_Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells.docx by Tingting Wang (123983)

“…Mechanistically, the protective effect of L. reuteri was associated with a decrease in the distribution of group 3 innate lymphocytes (ILC3s) induced by ICB associated colitis. …”

DataSheet1_Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.PDF by Anna M. Gutridge (9852364)

“…Yet, at 10 and 30 mg∙kg⁻¹ doses (i.p.), paynantheine did not counteract morphine CPP. 7-hydroxypaynantheine and 7-hydroxyspeciogynine displayed potency at δOR but limited µOR potency relative to 7-hydroxymitragynine in vitro, and dose-dependently decreased voluntary alcohol consumption in WT but not δOR in KO mice. 7-hydroxyspeciogynine has a maximally tolerated dose of at least 10 mg∙kg⁻¹ (s.c.) at which it did not produce significant CPP neither alter general locomotion nor induce noticeable seizures.…”

S5 File - by John N. Staffurth (20636565)

“…<div><p>To undertake a mixed-methodology implementation study to improve the well-being of men with gastrointestinal late effects following radical radiotherapy for prostate cancer. …”

Evolutionary Search and Theoretical Study of Silicene Grain Boundaries’ Mechanical Properties by Jianan Zhang (786459)

“…Twenty-one GBs with the lowest energy were validated by density functional theory (DFT), a majority of which were previously unreported to our best knowledge. …”

Descriptive statistics of participants. by Christopher I. Gurguis (19762408)

“…While there has been a large body of work trying to resolve this paradox by mapping genetic variation of this complex trait, there have been few direct empirical tests of the core assumption that there is consistent negative selection on depression in human populations. …”

Image_2_Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected by Piscirickettsia salmonis.tif by Diego Pérez-Stuardo (6477215)

“…Additionally, incubation with IgM-beads elicits a decrease in bacterial-induced cytotoxicity in infected Atlantic salmon macrophages and reduces the bacterial load. …”

DataSheet1_Revealing historical observations and future projections of precipitation over Northwest China based on dynamic downscaled CMIP6 simulations.doc by Xianyu Yang (775475)

“…Future precipitation projections suggest significant decreases of precipitation across the southern and eastern NW, with a stronger reduction magnitude in summer. …”

Table_2_Single-cell RNA sequencing analysis of lung cells in COVID-19 patients with diabetes, hypertension, and comorbid diabetes-hypertension.xlsx by Xin Zhang (35492)

“…</p>Results<p>The single-cell meta-analysis of lung samples from SARS-CoV-2-infected individuals with diabetes, hypertension, and hypertension-diabetes comorbidity revealed an upregulation of fibroblast subpopulations in these disease conditions associated with a predictive decrease in lung function. To further investigate the response of fibroblasts to therapeutic targets in hypertension and diabetes, we analyzed 35 upregulated targets in both diabetes and hypertension. …”

Experimental device set up. by Koki Ebina (14046862)

“…<div><p>This study developed and validated a surgical instrument motion measurement system for skill evaluation during practical laparoscopic surgery training. …”