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largest decrease » largest decreases (Expand Search), larger decrease (Expand Search), marked decrease (Expand Search)
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144261
image1_Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and I...
Published 2021“…Treatment with BME before or after MPTP administration has a protective effect on dopaminergic neurons, as evidenced by a significant decrease in GFAP immunostaining and expression of inducible nitric oxide synthase (iNOS) in the substantia nigra region; however, the degree of improvement was more prominent in mice receiving BME treatment before MPTP administration. …”
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144262
Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
Published 2017“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC<sub>50</sub> = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC<sub>50</sub> value. …”
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144263
Table1_Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program.XLSX
Published 2022“…We sought to determine genetic variants contributing to COVID-19 susceptibility and hospitalization in a large biobank linked to a national United States health system. …”
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144264
Image2_Computational analysis of cancer cell adhesion in curved vessels affected by wall shear stress for prediction of metastatic spreading.TIFF
Published 2024“…Quantitative analysis shows a 25% decrease in the wall shear stress in low-shear regions and a 58.5% increase in the high-shear region. …”
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144265
Table1_Balancing welfare and habitat damage in pigs (Sus scrofa) under extensive farming: an ethological approach for determining the effects of group composition and environmental...
Published 2024“…In enrichment conditions with straw, we found a significant decrease in anxiety-related, affiliation, and excavation behaviours levels, and a significant increase in non-invasive exploration behaviours. …”
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144266
Genetic Polymorphism of the Kinesin-Like Protein <i>KIF1B</i> Gene and the Risk of Hepatocellular Carcinoma
Published 2013“…Overall, the G allele at rs17401966 of the KIF1B gene was associated with a significantly decreased risk for HCC (OR = 0.81, 95%CI: 0.70–0.93; P = 0.003). …”
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144267
Data_Sheet_1_Macrogenomics reveal the effects of inter-cropping perilla on kiwifruit: impact on inter-root soil microbiota and gene expression of carbon, nitrogen, and phosphorus c...
Published 2024“…The results showed that intercropping with Perill caused a decrease in most soil nutrients, soil enzyme activities, and had a significant impact on the microbial (bacteria and fungi) diversity. …”
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144268
Data_Sheet_1_Nitrogen Source Matters: High NH4/NO3 Ratio Reduces Cannabinoids, Terpenoids, and Yield in Medical Cannabis.pdf
Published 2022“…This study demonstrates a dramatic impact of N form on cannabis plant function and production, with a 46% decrease in inflorescence yield with the increase in NH<sub>4</sub> supply from 0 to 50%. …”
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144269
Estimating the impact of city-wide <i>Aedes aegypti</i> population control: An observational study in Iquitos, Peru
Published 2019“…<div><p>During the last 50 years, the geographic range of the mosquito <i>Aedes aegypti</i> has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. …”
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144270
Rate-specific template effects on the STI (Wisler et al., 2025)
Published 2025“…</p><p dir="ltr">Wisler, A., Fletcher, A., & Mefferd, A. (2025). Does the spatiotemporal index (STI) overestimate instability in slow speech? …”
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144271
Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative Stress Pathway
Published 2016“…In addition, LPS intratracheal instillation induced marked oxidative damage, such as a decrease in total anti-oxidation products and an increase in malondialdehyde (MDA), as well as up-regulation of oxidation enzymes. …”
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144272
DataSheet2_Transcriptional time course after rotator cuff repair in 6 month old female rabbits.XLSX
Published 2023“…Many were also significantly enriched at 2 weeks, with the addition of NIF/NF-kappaB signaling, transcription in response to hypoxia, and mRNA stability alongside many additional pathways. There was also a shift in transcriptional activity at 4 weeks post-repair with significantly enriched pathways for lipids, hormones, apoptosis, and cytokine activity, despite an overall decrease in the number of differentially expressed genes. …”
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144273
Key characteristics of the included publications.
Published 2025“…Scoping review registered on OSF registries (<a href="https://osf.io/4mg7n" target="_blank">https://osf.io/4mg7n</a>).…”
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144274
Fig 1 -
Published 2025“…We compare the crop-aggregated domestic climate impact (sensitivity of crop yields of wheat, maize, and rice to future warming) (x-axis, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0314722#pone.0314722.s009" target="_blank">S4 Fig</a>) to the consumption impact on calorie supply i.e., climate impacts on both domestic and overseas supplying regions (y-axis, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0314722#pone.0314722.s009" target="_blank">S4 Fig</a>). …”
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144275
DataSheet_1_CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis.pdf
Published 2020“…Ivacaftor increased plasma concentrations of CXCL2, a neutrophil chemokine secreted by monocytes and macrophages, and CCL2, a monocyte chemokine.…”
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144276
The insulin<sup>+</sup> cells generated upon <i>Arx</i> inactivation are functional.
Published 2013“…While saline-treated animals developed significant insulin<sup>+</sup> and somatostatin<sup>+</sup> cell hyperplasia, as compared to controls, their glucagon-supplemented counterparts exhibited a diminished increase in insulin<sup>+</sup> and somatostatin<sup>+</sup> cell counts accompanied by a decrease in glucagon<sup>+</sup> cell number. n = 3 ** p<0.01, * p<0.07 using ANOVA comparing saline- and glucagon-treated animals. …”
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144277
Image_1_Temporal dynamics of sugar beet (Beta vulgaris L.) N supply from cover crops differing in biomass quantity and composition.jpg
Published 2022“…Thus, for environmentally effective cover cropping in Central Europe, species with a sufficiently high frost tolerance should be chosen. …”
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144278
DataSheet_1_CFTR Modulator Therapy Enhances Peripheral Blood Monocyte Contributions to Immune Responses in People With Cystic Fibrosis.pdf
Published 2020“…Ivacaftor increased plasma concentrations of CXCL2, a neutrophil chemokine secreted by monocytes and macrophages, and CCL2, a monocyte chemokine.…”
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144279
Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice
Published 2015“…<div><p>Background</p><p>Dietary energy restriction (DER) has been well established as a potent anticancer strategy. Non-adoption of restricted diet for an extended period has limited its practical implementation in humans with a compelling need to develop agents that mimic effects similar to DER, without reduction in actual dietary intake. …”
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144280
DataSheet_1_Pro-Resolving Factors Released by Macrophages After Efferocytosis Promote Mucosal Wound Healing in Inflammatory Bowel Disease.pdf
Published 2021“…<p>Nonresolving inflammation is a critical driver of several chronic inflammatory diseases, including inflammatory bowel diseases (IBD). …”