An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery by Sophie H. Narath (3095454)

“…Identified metabolites included trimethylamine-<i>N</i>-oxide, alanine, phenylalanine and indoxyl-sulfate which are known markers for cardiovascular risk. In addition we found a significant decrease in alanine after one year in the group of patients with diabetes remission relative to non-remission. …”

Table3_Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network... by Yingying Liu (360782)

“…Analysis of intestinal flora showed that HRG changed the composition of intestinal flora, which was characterized by a decrease in the Firmicutes/Bacteroidetes ratio. …”

DataSheet_3_Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induc... by Meiling Wang (808623)

“…Consistent with such suppression, Gent led to a significant decrease in IL-1β secretion by treated cells. …”

Image_6_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.TIFF by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

Table_2_Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease Severity.docx by Lorena Vigón (7325558)

“…<p>Infection by novel coronavirus SARS-CoV-2 causes different presentations of COVID-19 and some patients may progress to a critical, fatal form of the disease that requires their admission to ICU and invasive mechanical ventilation. …”

The Th17/Treg Ratio, IL-1RA and sCD14 Levels in Primary HIV Infection Predict the T-cell Activation Set Point in the Absence of Systemic Microbial Translocation by Mathieu F. Chevalier (424305)

“…<div><p>Impairment of the intestinal barrier and subsequent microbial translocation (MT) may be involved in chronic immune activation, which plays a central role in HIV pathogenesis. Th17 cells are critical to prevent MT. …”

Image 1_Screening of LAB strains and their co-culture fermentation with Bacillus subtilis of Cili fruit substrate: impact on γ-aminobutyric acid enrichment, key enzyme activities,... by Angelo Uriho (20992232)

“…Compared to B. subtilis fermented substrate (Bs), a significant decrease in pH (4.89, except BsLf), increase in TTA (19.30–29.20 mL) was observed after co-culture fermentation of Cili fruit. …”

Image_3_Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.TIFF by Suse Seidemann (18608065)

“…The assessments showed an increase in POS number, volume, and membrane coherency during wild-type postnatal development, while a decrease in all three observables was detected in different retinal degeneration mouse models. …”

CONSORT flow chart of included patients. by Zhiwei Li (131853)

“…Furthermore, PCV-VG was associated with an increased center of ventilation (45.1 ± 3.7 vs. 41.7 ± 3.5, P < 0.05), a decrease in global inhomogeneity (GI) (0.85 ± 0.16 vs. 1.06 ± 0.30, P < 0.05), and a reduction in regional ventilation delay index (RVDI) (10.5 ± 4.5 vs. 15.9 ± 5.3, P < 0.05), when compared to VCV. …”

Table 4_The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021.doc... by Shan Liu (193759)

“…Based on the BAPC model analysis, the ASIR and the age-standardized prevalence rate of diarrhea in Asia are predicted to decrease initially and then increase. The age-standardized DALY rate (ASDR) and the age-standardized mortality rate (ASMR) of diarrhea in Asia are predicted to demonstrate a consistent declining trend. …”

Image_2_Genetic Diversity in the Italian Holstein Dairy Cattle Based on Pedigree and SNP Data Prior and After Genomic Selection.TIF by Michela Ablondi (7402970)

“…The pattern of the effective population size based on pedigree and SNP data was similar although different in scale, with a constant decrease within the last five generations. …”

Image 3_Clinical isolates of Providencia rettgeri and Providencia Stuartii evades neutrophil-mediated killing by subverting neutrophil-extracellular traps.tif by Joselyn E. Castro (22355326)

“…This decrease was abolished by fixed bacteria, and was dependent on the release of a DNase activity. …”

Differentially Expressed Plasma MicroRNAs and the Potential Regulatory Function of Let-7b in Chronic Thromboembolic Pulmonary Hypertension by Lijuan Guo (404771)

“…The results showed that 1) thirty five microRNAs were differentially expressed in CTEPH patients, among which, a signature of 17 microRNAs, which was shown to be related to the disease pathogenesis by <i>in silico</i> analysis, gave diagnostic efficacy of both sensitivity and specificity >0.9. 2) Let-7b, one of the down-regulated anti-oncogenic microRNAs in the signature, was validated to decrease to about 0.25 fold in CTEPH patients. 3) ET-1 and TGFBR1 were direct targets of let-7b. …”

Table_1_Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats.DOCX by Takuya Koizumi (2667574)

“…We aimed to further investigate this, and examine whether the SGLT2-i empagliflozin suppresses mitochondrial-ROS generation and mitigates fibrosis.</p>Methods<p>A high-fat diet and low-dose streptozotocin treatment were used to induce type-2 DM (T2DM) in Sprague-Dawley rats. …”

image2_Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.tif by Haikang Zhou (10575770)

“…<p>Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects individuals worldwide. …”

Table_1_Densification of the Ground-Based GNSS Observation Network in the Southwest Indian Ocean: Current Status, Perspectives, and Examples of Applications in Meteorology and Geod... by Olivier Bousquet (9342110)

“…At the seasonal scale, maximum IWV values are similar everywhere, minimum values decrease away from the equator and a sharp IWV gradient can be noticed during the wet–dry transition period. …”

Table_2_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx by Yujia Zhang (757462)

“…The cell morphology altered dramatically 72 h after transfection, becoming rounder, with a decrease in cell number. BCP exhibited the potential to dramatically increase PC-12 cell viability while protecting cell morphology. …”

Image_1_Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via... by Junping Bao (10931142)

“…On the contrary, further activating p-eIF2α aggravated the NP cell degeneration, with amplification of ATF4/Ihh and a higher level of ROS and apoptosis. Additionally, applying cyclopamine (CPE) to suppress Ihh was efficient to prevent NP cell apoptosis but did not decrease the ROS level. …”

Targeted release of stromal cell-derived factor-1α by reactive oxygen species-sensitive nanoparticles results in bone marrow stromal cell chemotaxis and homing, and repair of vascu... by Fang He (43884)

“…This repair is achieved mainly via stromal cell-derived factor (SDF)-1α promoting the mobilization, chemotaxis, homing, and targeted differentiation of bone marrow mesenchymal stem cells (BMSCs) into endothelial cells. Forming a concentration gradient from the site of local damage in the circulation is essential to the role of SDF-1α. …”

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats by Andreea Oana Mocanu (803403)

“…These changes in gene expression were accompanied by a decrease in NLRP3, ASC, IL–18, caspase–1 and IL–1β protein expression in omental tissue. …”