Supplementary Material for: The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in... by Reuther C. (3593810)

“…In a Western blot analysis of GOT1 cells, NVP-CGM097 caused a dose-dependent increase in the expression of p53 and p21 tumor suppressor proteins and a decrease in phospho-Rb and E2F1. …”

p53 trans-activates the <i>Pax2</i> promoter. by Zubaida Saifudeen (135684)

“…<p><b>A</b>) <i>p53^−/−</i> H1299 cells were co-transfected with a p53 expression plasmid (pCMV-p53) and a 4.1-Pax2-CAT reporter construct. …”

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (<i>Ailuropoda melanoleuca</i>) reproductive monitoring by Jella Wauters (1657804)

“…To this extent, six cycles from two female pandas (SB741(1) and SB569(5)) were monitored through urine analysis for oestrogen, progesterone, ceruloplasmin and 13,14-dihydro-15-keto-PGF2a (PGFM). The Pearson’s correlation between creatinine and USpG was high (r = 0.805–0.894; p < 0.01), indicative for a similar performance of both normalisation methods. …”

Arkadia Ubiquitinates P-Smad2 and Mediates Its Degradation via the Proteasome by Konstantinos J Mavrakis (25033)

“…<div><p>(A and B) IP with anti-Flag antibody from <i>Akd</i>−/− MEFs transiently transfected with various plasmids as indicated, and Western blotted (WB) with anti-P-Smad2, anti-HA, or anti-ubiquitin antibodies. …”

Table_1_Farm-related determinants of food insecurity among livestock dependent households in two agrarian districts with varying rainfall patterns in Ghana.DOCX by Francis Sena Nuvey (6458915)

“…Household's odds of severe food insecurity decreased with each additional head of cattle in their herds (aOR = 0.97, 95% CI: 0.96, 0.99). …”

Atorvastatin reduces thrombus inflammation in murine VT at early timepoints. by Chase W. Kessinger (470740)

“…Mac-3 expression increased from day 4 to 10, while the other markers decreased (<b>A</b>). *p<0.05. Bars represent mean±SD. …”

Tongue pressure time course and the association of tongue pressure with modified MASA and NIHSS scores. by Masahiro Nakamori (490923)

“…The plot shows the mean values and the error bars indicate the standard deviation (A). …”

Effect of quinoline based 1,2,3-triazole and its structural analogues on growth and virulence attributes of <i>Candida albicans</i> - Fig 4 by Mohammad Irfan (464459)

“…High Pz value represents low enzyme activity. Compound 3a decreased proteinase secretion by two fold in FLC-resistant <i>C</i>. …”

Effects of IQ1 on mouse embryonic hearts. by Tomoyo Sasaki (87849)

“…Whole mount PECAM-1 immunostaining shows the coronary vascular network from a dorsal view of the hearts (arrows, bottom). IQ1 decreased the number of blood vessels. …”

Depletion of N-cadherin in olfactory epithelium upon <i>N. meningitidis</i> infection. by Hong Sjölinder (24530)

“…After infection, expression of N-cadherin was significantly decreased in both OE and the LP region. The data are presented as mean ± SD. …”

Changing stool OTUs visualized with an association network (<i>Viz</i>). by Gregor Gorkiewicz (280907)

“…The inset exemplifies one possible abundance progression showing an increasing-decreasing pattern. Only OTUs are displayed that were assigned to a respective reaction pattern in at least two individuals (corresponding to thin lines connecting OTUs with their pattern). …”

TNBS colitis reduces body weight, shortens colon length, damages epithelial barrier integrity and increases colonic IL-1β. by Ben R. Hofma (5439746)

“…<p>A) Body weight was significantly reduced 24 and 48 hours following TNBS treatment relative to healthy controls (▲ Healthy, ● TNBS, N = 10). …”

Alteration of β-catenin after treatment with ICG-001 and rapamycin. by Hye Sung Won (2794543)

“…<p>(A) The expression of β-catenin was decreased by ICG-001 and rapamycin. …”

Hypothermia suppressed MNU-mediated DNA demage by TGF-β1 unregulation and TNF-α down-regulation. by Gangjun Du (450828)

“…<p>A and B. Hypothermia decreased MNU-induced BEAS-2B cell DNA demage examined by comet assay. …”

Addition of GDP disrupts GPCR-G protein complexes. by Sumin Lu (4586644)

“…Traces represent the mean ± SD of 16 technical replicates from a single experiment, and each trace is normalized to the basal BRET observed for that particular G protein. …”

Ischemia depresses the amplitude of evoked synaptic transmission without changes in the presynaptic volley amplitude. by Shirin Jalini (2551054)

“…<p>(A). fEPSPs were recorded from the stratum radiatum in the CA1 region while the Schaffer collaterals were stimulated every 15 s. fEPEP amplitude decreased reversibly in a time-dependent manner after 2 min (n = 7), 4 min (n = 5), and 6 min (n = 5) of OGD. …”

Transfection of C/EBPα-saRNA in hepatoma cells inhibited migration, invasion and EMT. by Hongbo Huan (554599)

“…<p>(A-B) Wound healing assays of SMMC-7721 (A) and HepG2 (B) cells transfected with scramble-saRNA or C/EBPα-saRNA at 0 h, 12 h, and 24 h. …”

Intrathecal injection of spironolactone (Spir) improves pain behaviors after CCD surgery (n = 6/each). by Yu-e Sun (306280)

“…All data points represent mean±SD. Compared with sham group, chronic compression of the dorsal root ganglion (CCD) significantly decreased paw withdraw mechanical threshold (PWMT) (A) and thermal latency (PWTL) (B), ^*<i>P</i><0.01. …”

Involvement of clathrin-mediated endocytosis in NTBI uptake by PBMCs and HepG2 cells. by Joao Arezes (488491)

“…Each bar represents a mean value (n = 3) ± SD. Statistical significance is indicated by * symbols (*p<0.01). …”

Validation of top differential expressions of miRNAs. by Xian Shuang Liu (207926)

“…Real-time RT-PCR analysis shows ten of increased (B) and decreased (C) miRNAs detected on the microarray. Data are mean ± SE. …”