Enhancer-promoter pairs in the context of other interactions. by Boryana Doyle (648763)

“…This coloring convention continues throughout the paper. (<b>B</b>) A recent study in Drosophila suggested a 7 kb chromatin loop formed between Su(Hw) insulators (orange) could decrease E-P interactions (red “X”) <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003867#pcbi.1003867-Savitskaya1" target="_blank">[20]</a>. …”

Expression of <i>Suz12</i> and <i>Tet</i> genes correlated with the presence of methylcytosine (5mC) and hydroxymethylcytosine (5hmC) at the <i>Avp</i> locus during hypothalamic-li... by Chris Murgatroyd (373352)

“…<p>A, <i>Suz12</i> gene expression rapidly decreased following 4 days of Lif withdrawal. …”

Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection by Emmanouil Papasavvas (5406)

“…Here we present longitudinal follow-up of a randomized, open-label, single-center study of the immune, viral, and safety outcomes of structured therapy interruptions (TIs) in patients with chronically suppressed HIV-1 infection as compared to equal follow-up of patients on continuous therapy and including a final therapy interruption in both arms.…”

Table_1_Functional infrared thermography imaging can be used to assess the effectiveness of Maxicam Gel® in pre-emptively treating transient synovitis and lameness in horses.DOCX by Júlia Ribeiro Garcia de Carvalho (18804619)

“…The C group presented an increase in neutrophils and a decrease in total hemoglobin and hematocrit 8 h after induction. …”

Structural definition of the full VRC01-class bnAb epitope in the context of the Env trimer. by Joseph G. Jardine (3075186)

“…<p>(<b>A</b>) Crystal structure of eOD-N276Kif containing a Man₉GlcNAc₂ glycan at N276 in complex with VRC01, with the critical MinVRC01 mutations from germline shown as spheres and colored as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005815#ppat.1005815.g002" target="_blank">Fig 2B</a>. …”

Data_Sheet_1_Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies.pdf by Eli Hatchwell (8584452)

“…</p>Conclusion<p>For the first time, a PML genetic risk test can be implemented for screening patients taking or considering treatment with a PML-linked drug in order to decrease the incidence of PML and enable safer use of highly effective therapies used to treat their underlying disease.…”

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells by Elise Warcoin (3144120)

“…Adding NFAT5-siRNA before hyperosmolar stimulation led to a complete inhibition of CCL2 induction and to a decrease in cellular viability. p38 MAPK (p38), c-Jun NH₂-terminal kinase (JNK) and NFĸB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. …”

Fig 4 - by Yu Feng (445691)

“…At longer times, the distribution eventually returns to a symmetric distribution, leading to a decrease in SNR.…”

Hexokinase 2 (Hxk2) is the main 2DG-phosphorylating enzyme <i>in vivo</i>. by Clotilde Laussel (13237429)

“…Values are normalized to the value of the WT / 15 min (n = 3 independent experiments ± SEM, <i>p</i>value indicated, paired <i>t</i>-test) (<b>B</b>) 2DG causes a decrease in ATP content as visualized using a FRET ATP biosensor. …”

Integrated NMR interface and mutagenesis data illustrated onto the HPV16 E6 3D structure. by Katia Zanier (17371)

“…Side-chains that when mutated decrease E6/pep11** binding in mammalian two-hybrid assays by 1.5-fold or more (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112514#pone-0112514-g005" target="_blank">Figure 5C</a>) are displayed.…”

Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity by Gundegowda Kalligowdanadoddi Kiran (17654768)

“…Also, the results obtained from density functional theory (DFT + <i>U</i> = 0–8 eV), where <i>U</i> is the on-site Coulomb repulsion parameter also known as Hubbard <i>U</i>, based electronic structure calculations confirm that Zn doping constructively modifies the electronic structure, in both the valence band and the conduction band, and found to be suitable in tailoring the carrier’s effective masses of electrons and holes. The decrease in electron’s effective masses together with large differences between the effective masses of electrons and holes is noticed, which is found to be mainly responsible for achieving the best water-splitting performance from a 9% Zn-doped NiO sample prepared under vacuum.…”

Reversal of GABAergic postsynaptic currents by the ANO2 inhibitor. by Weiping Zhang (311523)

“…Application of the ANO2 inhibitor <i>(lower scheme)</i> reduces the Cl^- conductance. This causes a polarity reversal of the Cl^- driving force, as the balance shifts towards Cl^- extrusion, causing local [Cl^-]_i to decrease. …”

Metal−Metal Bonding and Correlated Metallic Behavior in the New Deficient Spinel Ga_0.87Ti₄S₈ by C. Vaju (2447485)

“…We have synthesized and characterized the first Ti member of the AM₄X₈ (A = Ga, Ge; M = V, Nb, Ta, Mo, X = S, Se) family of compounds that exhibit a deficient spinel structure with tetrahedral transition metal clusters. …”

Synthesis and Evaluation of Novel Substrates and Inhibitors of <i>N-</i>Succinyl-ll-diaminopimelate Aminotransferase (DAP-AT) from <i>Escherichia coli</i> by Russell J. Cox (225848)

“…Progress of the reaction is monitored by spectrophotometric observation of decrease in NADPH concentration at 340 nm in a coupled enzyme assay with l-glutamate dehydrogenase (EC 1.4.1.4). …”

Data_Sheet_1_Primary Productivity Dynamics in the Summer Arctic Ocean Confirms Broad Regulation of the Electron Requirement for Carbon Fixation by Light-Phytoplankton Community Int... by Yuanli Zhu (756179)

“…Specifically, the value of the linear slope describing PAR-K_C decreases as water bodies have an increasing fraction of larger phytoplankton. …”

DataSheet_1_Triglyceride glucose index is associated with functional coronary artery stenosis in hypertensive patients.docx by Shuting Wang (177744)

“…The TyG index increased the fraction of individuals with HRPs and HRPCs, FAI raised, and FFR_CT decreased (p < 0.05). The multivariate linear regression analysis illustrated a powerfulcorrelation between high TyG index levels and FAI, FFR_CT, positive remodeling (PR), and low-attenuation plaque (LAPs) (standardized regression coefficients: 0.029 [p = 0.007], -0.051 [p < 0.001], 0.029 [p = 0.027], and 0.026 [p = 0.046], separately).…”

Table_1_Cross-Sectional Associations of Neighborhood Perception, Physical Activity, and Sedentary Time in Community-Dwelling, Socioeconomically Diverse Adults.docx by Sophie E. Claudel (7379645)

“…<p>Background: Little is known about the role of perceived neighborhood environment as a determinant of physical activity (PA) and sedentary time (ST) in understanding obesity-related health behaviors. …”

Table_2_Pattern of prefrontal cortical activation and network revealed by task-based and resting-state fNIRS in Parkinson’s disease’s patients with overactive bladder symptoms.DOCX... by Miaomiao Hou (11135640)

“…</p>Methods<p>One hundred fifty-five idiopathic PD patients were recruited and classified either as PD-OAB or PD-NOAB candidates based on their corresponding OAB symptom scores (OABSS). A linear regression analysis identified a correlative connection of cognitive domains. …”

Table_1_Pattern of prefrontal cortical activation and network revealed by task-based and resting-state fNIRS in Parkinson’s disease’s patients with overactive bladder symptoms.XLSX... by Miaomiao Hou (11135640)

“…</p>Methods<p>One hundred fifty-five idiopathic PD patients were recruited and classified either as PD-OAB or PD-NOAB candidates based on their corresponding OAB symptom scores (OABSS). A linear regression analysis identified a correlative connection of cognitive domains. …”

Image 1_Association between daily variations in the levels of atmospheric O3, PM2.5, and NO2 and the frequency of hospital visits due to respiratory diseases and hypertension in Me... by Elizabeth Vega (13793101)

“…Background<p>Environmental pollution is a significant public health issue in Mexico City. …”