Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-med... by Xin Zi (10519149)

“…Osteosarcoma tissues presented with elevated positive expression rate of HGF, up-regulated expression levels of PCNA, HGF, PI3K, Akt, Bcl-2, ALP and OPN, and down-regulated expressions of Bax and LINC00619. HGF was verified as a target gene of lncRNA LINC00619. LINC00619 was found to down-regulate the expressions of PCNA, HGF, PI3K, Akt, Bcl-2, ALP, and OPN in osteosarcoma cells. …”

Detecting conservation benefits of marine reserves on remote reefs of the northern GBR by Carolina Castro-Sanguino (4579024)

“…Our results also suggest that fishers ‘fish the line’ as stock sizes in exploited areas decreased near larger no-take zones. Interestingly, an analysis of zoning effects on small, non-targeted fishes appeared to suggest a top-down effect from mesopredators, but was instead explained by variability in benthic composition. …”

Table 2_Metabolic readouts of tumor instructed normal tissues (TINT) identify aggressive prostate cancer subgroups for tailored therapy.docx by Ilona Dudka (8857529)

“…The levels of six metabolites differentiated between the two groups; myo-inositol, lysine, serine and combined signal of lysine/leucine/arginine were increased in benign samples near high-grade tumors (B ISUP 3 + 4) compared to near low-grade tumors (B ISUP 1 + 2), while levels of ethanolamine and lactate were decreased. Additionally, we revealed metabolic differences in non-cancer tissues as a function of their distance to the nearest tumor. …”

Table_2_Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection.xlsx by Si Yu (3828445)

“…Background<p>Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD) and has been reported as a risk factor for poor outcome. However, gut microbiome and mycobiome of IBD patients with CDI have been barely investigated. …”

Novel Electrosorption-Enhanced Solid-Phase Microextraction Device for Ultrafast In Vivo Sampling of Ionized Pharmaceuticals in Fish by Junlang Qiu (2803429)

“…Herein, for the first time, we report an ultrafast in vivo solid-phase microextraction (SPME) device based on electrosorption enhancement and a novel custom-made CNT@PPY@pNE fiber for in vivo sampling of ionized acidic pharmaceuticals in fish. …”

Data_Sheet_1_Temporal dynamics of total and active root-associated diazotrophic communities in field-grown rice.PDF by Xue Luo (529617)

“…The community composition (β-diversity) of total and active root-associated diazotrophs was shaped predominantly by microhabitat (niche; R² ≥ 0.959, p < 0.001), followed by growth period (R² ≥ 0.15, p < 0.001). The growth period had a stronger effect on endophytic diazotrophs than on rhizosphere diazotrophs. …”

DataSheet_1_The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E.pdf by Simon Brackenridge (14281595)

“…We confirmed that neither antibody cross-reacts with classical HLA alleles, and used hybrids of different MHC-E alleles to map the regions that are critical for their binding. 3D12 recognises a region on the alpha 3 domain, with its specificity for HLA-E resulting from the amino acids present at three key positions (219, 223 and 224) that are unique to HLA-E, while 4D12 binds to the start of the alpha 2 domain, adjacent to the C terminus of the presented peptide. 3D12 staining is increased by incubation of cells at 27°C, and by addition of the canonical signal sequence peptide presented by HLA-E peptide (VL9, VMAPRTLVL). …”

Data_Sheet_2_Effects of Chemical and Mechanical Lysis on Microbial DNA Yield, Integrity, and Downstream Amplicon Sequencing of Rumen Bacteria and Protozoa.xlsx by Zhi Yuan Ma (9644768)

“…Effects of chemical lysis and bead beating (BB) were investigated by conducting a 2 × 2 factorial-designed experiment with four methodologies, including QIA without (QIA−) and with BB (QIA + BB), and YM without (YM−) and with BB (YM + BB). …”

Lipocalin-2 Expressed in Innate Immune Cells Is an Endogenous Inhibitor of Inflammation in Murine Nephrotoxic Serum Nephritis by Kathrin Eller (135352)

“…<i>In vivo</i> blockade of HMGB-1, a toll-like receptor (TLR)-2 agonist, significantly reduced inflammation and NTS in Lcn-2 knock-out mice. …”

FEM analysis in excellent cushion characteristic of ostrich (<i>Struthio camelus</i>) toe pads by Rui Zhang (13940)

“…However, current studies often explains the cushion properties by analyzing the macro-microscopic structure of the pad organism, and there is a paucity of research on its biomechanical behaviour. …”

DataSheet_1_Dehydroalanine and dehydrobutyrine in aging and cataractous lenses reveal site-specific consequences of spontaneous protein degradation.pdf by Jessica Paredes (17286265)

“…The purpose of this study was to quantitate DHA and DHB in human lens proteins as a function of age and cataract status.</p>Methods<p>Human lenses of various ages were divided into five donor groups: transparent lenses (18–22-year-old, 48–64-year-old, and 70–93-year-old) and cataractous human lenses of two age groups (48–64-year-old lenses, and 70–93-year-old lenses) and were subjected to proteomic analysis. …”

Table_3_The Characteristics of Natural Killer Cells and T Cells Vary With the Natural History of Chronic Hepatitis B in Children.docx by Yingzhi Zhou (11754956)

“…Fresh peripheral blood drawn from hepatitis B virus (HBV)-infected and healthy children was processed to perform flow cytometric analysis.</p><p>Results: A total of 112 treatment-naive children with CHB and 16 comparable healthy controls were included in this study. …”

Table_4.XLSX by Hui Cao (182176)

“…Overall, our results suggest that DGLHD aims at multiply targets and impedes the progression of hepatic fibrosis by ameliorating abnormal inflammation and ECM deposition, thereby serving as a novel regimen for treating hepatic fibrosis in clinic.…”

Sex Differences in HIV Prevalence Persist over Time: Evidence from 18 Countries in Sub-Saharan Africa by Hanne K. Hegdahl (2161192)

“…In 13 out of 18 countries the prevalence ratio was higher for the younger age group compared to the age group 25–49 years (3 significant) and this difference in prevalence ratios between the age groups did not change over time. Overall, there was a higher frequency of increasing than decreasing prevalence ratios. …”

Reduction of Connexin36 Content by ICER-1 Contributes to Insulin-Secreting Cells Apoptosis Induced by Oxidized LDL Particles by Jacques-Antoine Haefliger (134116)

“…<div><p>Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the Langerhans islets, contributes to the proper control of insulin secretion and beta-cell survival. …”

Video_2_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…HIV induced NET formation through non-lytic pathways in blood and FGT neutrophils, except for a small subset of NETs that incorporated annexin V and lactoferrin predominantly in blood, suggesting proinflammatory and lytic NET release. …”

Data_Sheet_1_Negative emotion can be “more negative” for those with high metacognitive abilities when problem-solving.docx by Seok-sung Hong (14788519)

“…</p>Discussion<p>These findings suggest a novel and complicated interaction between emotion and metacognition and warrant further research.…”

Inner-IoU. by Chunhua Yang (346871)

“…<div><p>This study proposes the S-YOLOv10-ASI algorithm to improve the accuracy of tea identification and harvesting by robots, integrating a slice-assisted super-reasoning technique. The algorithm improves the partial structure of the YOLOv10 network through space-to-depth convolution. …”

Data_Sheet_1_Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling.docx by Shih-Ya Hung (10884743)

“…Background<p>Acupuncture or electroacupuncture (EA) appears to be a potential treatment in acute clinical traumatic brain injury (TBI); however, it remains uncertain whether acupuncture affects post-TBI histone deacetylase (HDAC) expression or impacts other biochemical/neurobiological events.…”

DataSheet_1_Contribution of aged organic carbon to suspended particulate organic carbon in the western equatorial Indian Ocean.docx by Sujin Kang (456330)

“…Higher values of δ¹³C_POC and Δ¹⁴C_POC near the surface indicated an influence of autochthonous POC, whereas decreasing trends toward the bottom suggested a contribution of aged OC sources to the total POC pool. …”