DataSheet_1_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.pdf by Yuan Gao (159945)

“…Inhibition of miR-222-3p significantly suppressed the migration of B-CPAP and induced a mesenchymal-epithelial transition (MET) phenotype via the Snail transcription factor. …”

Image 1_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Image3_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.TIF by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

Formation of Zn(II) and Cd(II) Coordination Polymers Assembled by Triazine-Based Polycarboxylate and <i>in-Situ</i>-Generated Pyridine-4-thiolate or Dipyridylsulfide Ligands: Obser... by Qilong Zhu (2048197)

“…Three novel coordination polymers, [Cd₅(HTTHA)₂(Hpt)₄(H₂O)]·4H₂O (<b>1</b>; H₆TTHA = 1,3,5-triazine-2,4,6-triamine hexaacetic acid, Hpt = pyridinium-4-thiolate), {[Cd₃(TTHA)(dps)(H₂O)₃]₂}·H₂O (<b>2</b>), and [Zn₃(TTHA)(dps)(H₂O)]·5H₂O (<b>3</b>; dps =4,4′-dipyridylsulfide), have been synthesized by the flexible hexapodal acid H₆TTHA and <i>in-situ</i>-generated Hpt and dps ligands from a 4,4′-dipyridyldisulfide (dpds) precursor through cleavage of both S–S and S–C(sp²) bonds and temperature-dependent chemical rearrangement under hydrothermal conditions. …”

Image_1_Calcium-Sensing Receptor Participates in High Glucose-Induced EndMT in Primary Human Aortic Endothelial Cells.JPEG by Cheng Yuan (160315)

“…The in vitro results showed that HG significantly inhibited the expression of CD31 and increased FSP1 and α-SMA in a concentration- and time-dependent manner. Moreover, CaSR was increased in HAECs after HG treatment. …”

Image_3_Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasi... by M-K. Torp (12332864)

Image 2_Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling.jpeg by Yiwen Li (354034)

“…PI3K signaling pathway was identified as a central mediator of the microbiota interaction in DMIRI. …”

Phloroglucinol attenuates the 6-OHDA-mediated loss of antioxidant enzymes in SH-SY5Y cells and rat brains. by Junghwa Ryu (448435)

“…<p>(<b>A</b>) 50 µg of protein was added to 50 mM phosphate buffer (pH 7) containing 100 mM H₂O₂. …”

Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment by Amelia S. Power (6569951)

“…This study examined RV mitochondrial function and ADP transfer in PH animals advancing to right heart failure, and investigated a potential therapy with the specific β₁-adrenergic-blocker metoprolol. …”

<i>Helicobacter pylori</i> Cholesteryl α-Glucosides Contribute to Its Pathogenicity and Immune Response by Natural Killer T Cells by Yuki Ito (29604)

“…Phagocytosis and activation of dendritic cells were observed at similar degrees in the presence of wild-type <i>H. pylori</i> or variants harboring mutant forms of αCgT showing a range of enzymatic activity. However, cholesteryl α-glucosides were recognized by invariant natural killer T (<i>i</i>NKT) cells, eliciting an immune response <i>in vitro</i> and <i>in vivo</i>. …”

Long-Term Observations Reveal Enhanced Nighttime Formation of Nitrated PAHs Following Primary Emission Reduction by Xiaodi Shi (1542910)

“…∑₁₂NPAHs decreased by 89.2% (2350 pg m^–3 to 254 pg m^–3), a slower decline than that of ∑₁₆PAHs determined using the same samples. …”

Enols of Amides Activated by the 2,2,2-Trichloroethoxycarbonyl Group by Ahmad Basheer (1914646)

“…Intramolecular hydrogen bonds result in a very low δ(OH) and contribute to the stability of the enols and are responsible for the higher percentage of the <i>E</i>-isomers when Y = CO₂Me and the <i>Z</i>-isomers when Y = CN. …”

Data_Sheet_1_Diet Modulates the High Sensitivity to Systemic Infection in Newborn Preterm Pigs.docx by Ole Bæk (7482194)

“…Sensitivity to systemic SE infection decreases rapidly in the days after preterm birth. …”

Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia by Natanja Oosterom (5492705)

Supplementary Material for: Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory by Tsai S.-F. (5179754)

“…Thus, long-term, moderate intensity exercise training might be a way of delaying and treating aging-related memory decline.…”

Image_2_Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2.jpg by Cong Cong Sun (9501830)

“…<p>Gestational diabetes mellitus (GDM) causes oxidative stress in mothers and infants and causes vascular endothelial dysfunction, which is a key factor for maternal and fetal cardiovascular diseases in the later stage of GDM, seriously threatening the life and health of mothers and infants. …”

Table_1_Bacterial Modulation of the Plant Ethylene Signaling Pathway Improves Tolerance to Salt Stress in Lettuce (Lactuca sativa L.).DOCX by Jonathan Fortt (5772662)

“…Strains ESL007 and SH31 triggered a higher catalase and ascorbate-peroxidase activity, compared to non-stressed plants. …”

Image 3_Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes.tiff by Zhangyao Su (5980565)

“…Gut-tropic CD8⁺ T cells showed augmented cytokine production and cytotoxicity against islet cells. Integrin α4β7 was a key mediator of the pathogenicity of CD8⁺ T cells and upregulated by the inflammatory signals. …”

Image_1_MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma.tif by Meng Li (79487)

“…MECOM and PRDM16 were also found to be correlated with the expression of a variety of immune cell subsets and their markers. …”

Image_1_Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease.tif by Kentaro Ueno (9253486)

“…Following treatment of KD serum-activated HCAECs with PSL or PBS as a control, effects on the HMGB-1 signaling pathway were evaluated. …”