Image_1_Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma.tif by Nan Zhao (351674)

“…Although confocal microscopy demonstrated that AR is expressed but not specifically in glioma cancer stem cells (CSCs) (CD133+), enzalutamide treatment significantly decreased CSC population in cultured monolayer cells and spheroids, suppressed tumor sphere-forming capacity of GBM cells, and downregulated CSC gene expression at mRNA and protein levels in a dose- and time-dependent manner. …”

Image_2_Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma.tif by Nan Zhao (351674)

“…Although confocal microscopy demonstrated that AR is expressed but not specifically in glioma cancer stem cells (CSCs) (CD133+), enzalutamide treatment significantly decreased CSC population in cultured monolayer cells and spheroids, suppressed tumor sphere-forming capacity of GBM cells, and downregulated CSC gene expression at mRNA and protein levels in a dose- and time-dependent manner. …”

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism by Ying Wang (11406)

“…<div><h3>Background</h3><p>DCB-3503, a tylophorine analog, inhibits the growth of PANC-1 (human pancreatic ductal cancer cell line) and HepG2 (human hepatocellular cancer cell line) tumor xenografts in nude mice. …”

Prenyllongnols A–D, New Prenylated Acylphloroglucinols that Fight Concanavalin A‑Induced Autoimmune Hepatitis by Zhengyi Shi (8978924)

“…Furthermore, in a Con A-challenged autoimmune hepatitis mouse model, the mice in the group that were pretreated with isolate <b>2</b> significantly ameliorated liver injury and decreased proinflammatory cytokine production. …”

RhoA as a signaling hub controlling glucagon secretion from pancreatic α-cells by Xue Wen Ng (13162930)

“…Pharmacological inhibition of RhoA disrupts glucose inhibition of glucagon secretion in islets and decreases cortical F-actin density in dispersed α-cells and α-cells in intact islets.  …”

A 3D Fibrous Scaffold Inducing Tumoroids: A Platform for Anticancer Drug Development by Yvonne K. Girard (471304)

“…<div><p>The development of a suitable three dimensional (3D) culture system for anticancer drug development remains an unmet need. …”

Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor by Kurtis Eisermann (95302)

“…Co-immunoprecipitation assays confirmed the association of PABPC1 with a.a. 50-250 of the NTD of the AR. Knockdown of PABPC1 decreased nuclear AR protein levels and inhibited androgen activation of the AR target PSA in LNCaP and C4-2 cells. …”

Dry immersion as a model of deafferentation: A neurophysiology study using somatosensory evoked potentials by Blandine Acket (5675420)

“…<div><p>Introduction</p><p>Dry immersion is a ground-based experiment simulating the effects of weightlessness, and it is a model of acute symmetrical bilateral deafferentation. …”

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma by Lenka Besse (798072)

“…Further, microRNA-130a was decreased in bone marrow plasma cells obtained from patients with extramedullary myeloma in comparison to bone marrow plasma cells of myeloma patients without such manifestation, but it was increased in tumor site plasma cells of patients with extramedullary disease compared to bone marrow plasma cells of such patients (<i>p</i><0.0001). …”

<em>Fabp7</em> Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype by Akiko Watanabe (36386)

“…<em>Fabp7</em>-deficient mice showed decreased PPI and a shortened startle response latency, typical of the QTL's proposed effects. …”

The primary evaluation and characterization of obsolete DDT pesticide from a precalciner of a cement kiln by Yang Li (7082)

“…The release of chlorine reached a peak between 800 °C and 900 °C. It was found that the oxygen content had a positive correlation with the process of dechlorination. …”

SIRT3 partially mediates the transcriptional signature of delayed aging that is also indicative of risk of disease in mice and humans. by Jamie L. Barger (246202)

“…(<i>B</i>) Consumption of a high fat diet in mice, obesity in humans, and individuals diagnosed with polycystic ovary syndrome (PCOS) display the inverse transcriptional pattern for the longevity signature, whereas (C) interventions that decrease risk of disease (treatment with thiazolidinediones in mice and humans, consumption of resveratrol and weight loss) show an induction of the transcriptional signature of delayed aging. …”

Mechanosynthesis of a Coamorphous Formulation of Creatine with Citric Acid and Humidity-Mediated Transformation into a Cocrystal by Kyle B. Pekar (9936319)

“…Creatine is recognized as a dietary staple among athletes, with two supplement formulations currently available on the United States market: creatine monohydrate and creatine hydrochloride. …”

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection by Jonathan Maelfait (181048)

“…This phenotype is not due to decreased viral replication. Instead host innate and adaptive immune responses and lung damage are reduced in A20^AEC-KO mice. …”

Supplementary Material for: Development of a root caries prediction model in a population of dental attenders by Fee P.A. (13545517)

“…However, there is generally no accepted practice to identify individuals at risk of disease. There is a need for the development of a root caries prediction model to support clinicians to guide targeted prevention strategies. …”

Adaptation via altruistic mutations for all <i>k</i>. by Hanna Isaksson (747571)

“…In life cycles with higher <i>k</i>, mutations spread for a smaller range of parameters, and the range decreases as the environment changes from <i>E</i>_<i>B</i> to <i>E</i>_<i>C</i>.…”

Video_1_In-vitro Characterization of a Hernia Mesh Featuring a Nanostructured Coating.MOV by Giulia Giuntoli (10008728)

“…<p>Abdominal hernia repair is a frequently performed surgical procedure worldwide. …”

Molecular Dynamics of Polymyrcene: Rheology and Broadband Dielectric Spectroscopy on a Stockmayer Type A Polymer by Ciprian Iacob (2132437)

“…However, at molecular weights greater than the reptation molecular weight <i>M</i>_r, a molecular weight substantially larger than the entanglement molecular weight <i>M</i>_e, the zero shear viscosity scaling decreases. …”

Ubiquitin-Specific Peptidase 5, a Target Molecule of Vialinin A, Is a Key Molecule of TNF-α Production in RBL-2H3 Cells by Yasukiyo Yoshioka (492618)

“…<div><p>Tumor necrosis factor alpha (TNF-α), a central mediator of the inflammatory response, is released from basophilic cells and other cells in response to a variety of proinflammatory stimuli. …”

Workflow for multi-modal imaging of HSV-1 infected cells. by Kamal L. Nahas (13014698)