DataSheet1_From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study.docx by Živa Ramšak (3480629)

“…<p>The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. …”

Image_1_A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates.TIF by Ji-Dong Xu (5700842)

“…These results confirmed the antibacterial function of MjRhoA in shrimp. Further study showed that rate of phagocytosis of hemocytes was decreased in MjRhoA-knockdown shrimp. …”

Image2_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.TIF by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Table2_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.PDF by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Image1_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.TIF by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Image3_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.TIF by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Image_2_A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates.TIF by Ji-Dong Xu (5700842)

“…These results confirmed the antibacterial function of MjRhoA in shrimp. Further study showed that rate of phagocytosis of hemocytes was decreased in MjRhoA-knockdown shrimp. …”

Table1_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.XLSX by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Image4_Causal associations and potential mechanisms between inflammatory skin diseases and IgA nephropathy: a bi-directional Mendelian randomization study.TIF by Wenlong Cao (7491566)

“…In the combined microarray dataset, the expression levels of GALNT12 and C1GALT1C1 in atopic dermatitis patients were significantly lower compared with controls (p = 2.3e⁻⁹; p = 0.00067), which may contribute to an increase in aberrant IgA1 synthesis.</p>Conclusion<p>Among inflammatory skin diseases, atopic dermatitis was found to increase the risk of IgA nephropathy, which may result from the decrease of GALNT12 and C1GALT1C1 expression and the increase of aberrant IgA1 production. …”

Data_Sheet_2_Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy.XLSX by Lu Gao (44114)

“…In addition, the antihypertrophic effect of LAPTM5 was largely blocked by constitutively active mutant Rac1 (G12V). …”

Data_Sheet_1_Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy.PDF by Lu Gao (44114)

“…In addition, the antihypertrophic effect of LAPTM5 was largely blocked by constitutively active mutant Rac1 (G12V). …”

Table_1_Non-motor Behavioral Alterations of PGC-1α-Deficient Mice – A Peculiar Phenotype With Slight Male Preponderance and No Apparent Progression.DOCX by Levente Szalardy (5686679)

“…The present study revisited prior observations of anxiety-related, depression-related, and hippocampal memory-related observations having been made on different PGC-1α-deficient murine strains, in a large-scale analysis on whole-body full-length (FL-)PGC-1α-deficient mice. …”

Identification of <i>T. gondii</i> Myosin Light Chain-1 as a Direct Target of TachypleginA-2, a Small-Molecule Inhibitor of Parasite Motility and Invasion by Jacqueline M. Leung (120235)

“…Finally, a knock-in parasite line expressing the C58S mutation showed decreased sensitivity to compound treatment in a quantitative 3D motility assay. …”

DataSheet1_Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis.docx by Menglong Shi (16450710)

“…<p>Background: Coronary heart disease (CHD) poses a serious threat to public health, and the current medical management still faces significant challenges. …”

Table1_Depression in systemic lupus erythematosus: Modifiable or inheritable? a two-sample mendelian randomization study.XLSX by Jinyun Chen (264711)

“…Single nucleotide polymorphisms (SNPs) associated with SLE were selected as instrumental variables (IVs) from a genome-wide association study (GWAS) of 14,267 European-ancestry participants. …”

DataSheet1_Flexible Power and Biomass-To-Methanol Plants With Different Gasification Technologies.docx by A. Poluzzi (12008492)

“…Economic advantages may be derived from a decrease in the electrolysis capital investment, especially for the direct gasification-based plants, which employ the greatest sized electrolyzer. …”

Data_Sheet_1_A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer.docx by Joanie Del Bano (6939530)

“…Its overexpression in breast tumors has been recently correlated with a decreased disease-free survival and an increase of distant metastases. …”

Video_1_Immunohistochemical Evaluation of Histological Change in a Chinese Milroy Disease Family With Venous and Skin Abnormities.MOV by Sijia Zhang (1573870)

“…And what is added to our knowledge: (1) Capillary hyperemia and phlebectasia is severe; (2) Vascular malformations; (3) The number of vascular endothelial cells and vascular smooth muscle cells decreased; (4) Large sheets of epidermis desquamated; (5) The numbers of cutaneous appendages reduced in MD.…”

Video_1_A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer.MP4 by Joanie Del Bano (6939530)

“…Its overexpression in breast tumors has been recently correlated with a decreased disease-free survival and an increase of distant metastases. …”

Growing up with a single mother and life satisfaction in adulthood: A test of mediating and moderating factors by David Richter (4112512)

“…Individuals who grew up with a single mother for their entire childhood and to a lesser degree also individuals who experienced parental separation showed a small but persistent decrease in life satisfaction into old age controlling childhood socio-economic status. …”