DataSheet5_Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic pr... by Osvaldo Contreras (780538)

“…<p>Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic development, wound healing, carcinogenesis, and fibrosis, via effects on cell migration, proliferation and differentiation. …”

Image1_Control of Orthodontic Tooth Movement by Nitric Oxide Releasing Nanoparticles in Sprague-Dawley Rats.TIF by Derrick Crawford (12414670)

“…Results: Nanoparticles released a burst of NO within the first hours at approximately 10 ppb/mg particles that diminished by 10 × to approximately 1 ppb/mg particles over the next 1–4 days, and then diminished again by tenfold from day 4 to day 7, at which point it was no longer measurable. …”

Enhanced cell death in Ku70 KD cells is caspase-dependent. by Mohamed K. Hassan (550762)

“…<p><b><i>A</i></b>. Ku70 KD and control PC-10 cells were treated with hyperthermia (42.5°C) for 6 h in presence or absence of caspase inhibitor (Z-VAD; 50 nM). …”

Image_1_Acute Fasting Does Not Induce Cognitive Impairment in Mice.JPEG by Hua Zheng (1787305)

“…In the present system establishment study, a mouse model of acute fasting was established. …”

Image_2_Insights Into the MYB-Related Transcription Factors Involved in Regulating Floral Aroma Synthesis in Sweet Osmanthus.JPEG by Xin Yan (17064)

“…In this study, we conducted a genome-wide analysis of MYB-related proteins in sweet osmanthus; 212 OfMYB-related TFs were divided into three distinct subgroups based on the phylogenetic analysis. …”

Image_1_Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis.tif by Youdong Wan (14766238)

“…</p>Conclusions<p>Our findings suggested that metformin could improve SALI and gut microbiota in aged rats, which could provide a potential therapeutic treatment for SALI in aged sepsis.…”

An <i>in vitro</i> evaluation of the effects of different statins on the structure and function of human gut bacterial community by Changhui Zhao (634155)

“…<div><p>Statins, a class of drugs that can effectively remove cholesterol from serum, are used to regulate plasma total cholesterol and reduce the risk of cardiovascular diseases, but it is still unclear whether the drug are modulated by gut microbiota or the structures of gut microbiota are shaped by statins. …”

DataSheet_1_Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients.xlsx by Júlia Teixeira Cottas de Azevedo (11816621)

“…Overall survival was 94% with no severe (grade III-IV) graft-vs-host disease and a 22% rejection rate (graft failure). Hematological parameters, reticulocyte counts, and levels of lactate dehydrogenase (LDH), endothelin-1 and VCAM-1 normalized in SCD patients post-HSCT. …”

Table 1_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.xlsx by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Table_1_Effects of fermented feed of Pennisetum giganteum on growth performance, oxidative stress, immunity and gastrointestinal microflora of Boer goats under thermal stress.DOCX by Yuyang Qiu (8926436)

“…The CAT, GSH-Px activities and GSH in serum, liver and spleen, and the levels of IgA, IgG, IgM, IL-2, IL-4 and IL-1β in serum of FPG-fed goats were significantly higher (p < 0.05) than those of NPG-feeding goats. …”

Image_3_Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.tif by Laura Kröhn (17011479)

“…However, higher IL37 expression correlated with a reduced proinflammatory cytokine response in murine colonic organoids. …”

Data_Sheet_1_Heat Waves Alter Carbon Allocation and Increase Mortality of Aleppo Pine Under Dry Conditions.docx by Benjamin Birami (8541753)

“…<p>Climate extremes are likely to occur more frequently in the future, including a combination of heat waves and drought. However, the responses of trees to combined stress and their post-stress recovery are not fully understood yet. …”

Image_1_Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults.TIF by Xin Wang (91924)

“…Moreover, subgroup analyses by age, sex, and body mass index suggested a consistent significant correlation (p < 0.05).…”

Image_6_Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.tif by Laura Kröhn (17011479)

“…However, higher IL37 expression correlated with a reduced proinflammatory cytokine response in murine colonic organoids. …”

Image_3_ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway.TIFF by Shenglin Gao (10142900)

“…The potential mechanism affected by ATF3 was analyzed through gene set enrichment analysis (GSEA) and verified using western blotting, invasion assay, or immunofluorescence staining. Furthermore, a xenograft mouse model was used to assess the function of ATF3 in vivo.…”

Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. We herein reported a series of novel substituted <i>N</i>-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues as potent HAdV inhibitors. …”

DataSheet_1_The Risk of Arterial Thrombosis in Patients With Chronic Myeloid Leukemia Treated With Second and Third Generation BCR-ABL Tyrosine Kinase Inhibitors May Be Explained b... by Hélène Haguet (3365288)

“…Here, we aimed to provide an in vitro homogenous evaluation of the effects of BCR-ABL TKIs on the endothelium, with a special focus on the type of cell death to elucidate the mechanisms responsible for the potential cytotoxic effects of BCR-ABL TKIs nilotinib and ponatinib on endothelial cells. …”

DataSheet8_Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic pr... by Osvaldo Contreras (780538)

“…<p>Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic development, wound healing, carcinogenesis, and fibrosis, via effects on cell migration, proliferation and differentiation. …”

DataSheet1_Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathwa... by Wilbert Bouwman (9534287)

“…Differential diagnosis remains a challenge. Anti-TNFα treatment is an important treatment for IBD, yet resistance frequently occurs and cannot be predicted. …”

Proteomic analysis of the response of <i>Trichinella spiralis</i> muscle larvae to exogenous nitric oxide by Xiaoli Wang (46677)

“…Herein, we applied label-free analysis to investigate the effect of sodium nitroprusside (SNP, a NO donor compound) on the proteome of <i>T</i>. …”