DataSheet_1_Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model.pdf by Razan M. Alajoleen (17630292)

“…We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus through bacterial flagellin-mediated activation of toll-like receptor 5 (TLR5).…”

Table_1_ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway.DOCX by Shenglin Gao (10142900)

“…The potential mechanism affected by ATF3 was analyzed through gene set enrichment analysis (GSEA) and verified using western blotting, invasion assay, or immunofluorescence staining. Furthermore, a xenograft mouse model was used to assess the function of ATF3 in vivo.…”

Vd<i>Crz1</i> signaling is involved in penetration peg development and pathogenicity of <i>V</i>. <i>dahliae</i>. by Yun-Long Zhao (359083)

“…<p><b>A.</b> Expression analysis of the Vd<i>Crz1</i> signaling-related gene in V592, Vd<i>Δnoxb</i>, Vd<i>Δpls1</i> and Vd<i>Δcrz1</i>(left panel), as well as in Vd<i>Δnoxb</i> and Vd<i>Δpls1</i> with OH·-treatment (right panel). …”

DataSheet_1_Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.zip by Han Jiang (195350)

“…MP treatment resulted in decreased frequencies of T cells and NK cells, inhibited NK cell activation and T cell differentiation, and more profoundly, a marked shift in the distribution of monocyte subsets. …”

Table_6_Integrative Analysis of LGR5/6 Gene Variants, Gut Microbiota Composition and Osteoporosis Risk in Elderly Population.DOCX by Dong-sheng Di (11634688)

“…The rs10920362 CT/TT genotype associated with a decreased relative abundance of Actinobacteria (β = −1.32, P < 0.001), Bifidobacteriaceae (β = −1.70, P < 0.001), and Bifidobacterium (β = −1.70, P < 0.001) compared to the CC genotype.…”

Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease by Todd Atherly (2166001)

“…Apicaljunction protein (AJP) expression using immunohistochemistry investigated the effect of medical therapy on intestinal barrier integrity. All IBD dogs had a reduction in GI signs following diet and prednisone therapy compared with baseline CIBDAI scores (<i>P</i> < 0.05). …”

Image2_Correlation Between Immune-Related Genes and Tumor-Infiltrating Immune Cells With the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.TIF by Yan Zhou (6523)

“…Among the many biomarkers predicting the efficacy of NAC, immune-related biomarkers, such as immune-related genes and tumor-infiltrating lymphocytes (TILs), play a key role.</p><p>Methods: We analyzed gene expression from several datasets in the Gene Expression Omnibus (GEO) database and evaluated the relative proportion of immune cells using the CIBERSORT method. …”

DataSheet_6_Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction... by Siqi Xu (429196)

“…We confirmed this mechanistic effect in a CLP-induced sepsis model of intestinal SIRT3 conditional-knockout mice, and found that melatonin preserved mitochondrial function and induced autophagy of small-intestine epithelial cells; these effects were dependent on SIRT3 activation. …”

ESI–MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts by Norelle C. Wildburger (1538671)

“…However, recent evidence has demonstrated the promise of bone marrow-derived mesenchymal stem cells (BM-hMSCs) as a therapeutic delivery vehicle for anti-glioma agents due to their ability to migrate or home to human gliomas. …”

DataSheet1_Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies.pdf by Alice Main (13908828)

“…Overexpression of zDHHC5 in rabbit ventricular cardiomyocytes did not alter palmitoylation of its substrates or overall cardiomyocyte contractility, suggesting changes in zDHHC5 expression in disease may not be a primary driver of pathology. zDHHC5 itself is regulated by post-translational modifications, including palmitoylation in its C-terminal tail. …”

Table 2_Microbial diversity and community assembly in heavy metal-contaminated soils: insights from selenium-impacted mining areas.docx by Zhiyong Wang (313131)

“…<p>The mining industry in China plays a pivotal role in economic development but also leads to severe environmental issues, particularly heavy metal pollution in soils. …”

Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage by Yijun Cheng (10296278)

“…Ferroptosis, a form of regulatory non-apoptotic cell death driven by iron-dependent lipid peroxidation, accounts for more than 80% of the total types of neuronal death in the acute phase of intracerebral hemorrhage (ICH). …”

Image_4_Synergistic and Antagonistic Effects of Biogenic Silver Nanoparticles in Combination With Antibiotics Against Some Pathogenic Microbes.jpg by Kawther Aabed (9674992)

“…The synergistic effects of biogenic AgNPs in combination with some antibiotics support their potential as a safe therapeutic for bacterial infections because they are capped with organic biomolecules.…”

Image_1_Carbon Amendments Influence Composition and Functional Capacities of Indigenous Soil Microbiomes.tif by José Pablo Dundore-Arias (6517574)

“…Mesocosms were established with soil from two field sites varying in soil organic matter content (low organic matter, LOM; high organic matter, HOM), that were amended at intervals over nine months with low or high dose solutions of glucose, fructose, malic acid, a mixture of these compounds, or water only (non-amended control). …”

Image2_Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice.pdf by Elena M. Yee (14852698)

“…<p>Introduction: A hallmark of aging is poor muscle recovery following disuse atrophy. …”

DataSheet4_Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway.XLSX by Qin Ru (11623021)

“…The combination of network pharmacology approaches with experimental validation may offer a useful tool to characterize the molecular mechanism of multicomponent complexes.…”

Table_2_Microbial community diversity of an integrated constructed wetland used for treatment of sewage.XLSX by Nidhi Seth (18173680)

“…<p>The microbial community diversity in Constructed Wetland System (CWS) plays a key role in the removal of pollutants from waste water. …”

Table_1_Change of mortality of patients with acute ischemic stroke before and after 2015.docx by Sang-Won Park (180226)

“…</p>Materials and methods<p>A retrospective cohort study was conducted using combined anonymized data from the Acute Stroke Assessment Registry of Korea and the Health Insurance Review & Assessment Service database. …”

Image_3_Splenic SUMO1 controls systemic inflammation in experimental sepsis.jpeg by Ayman Youssef (16537653)

“…In the spleen, endotoxemia induced a distinct temporal and substrate specificity for SUMO1 and SUMO2/3, and both were inhibited by TAK981. …”

Table_1_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…</p>Results<p>In the primary analysis with 249 traits, we found that plasma triglycerides were positively associated with pancreatitis risk. Intriguingly, a large number of traits associated with saturation or unsaturation of fatty acids also demonstrated causal associations. …”