Original study data. by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

S2 File - by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

Localization and interaction of chemotaxis proteins CheY and CheZ. by Thorsten Wille (505378)

“…Addition (black arrows) and removal (blue arrows) of the chemotactic attractant MeAsp resulted in a decrease (no interaction) or increase (interaction) of the YFP/CFP quotient, respectively.…”

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction by Daohai Du (1714372)

“…Disruption of EZH2–embryonic ectoderm development (EED) protein–protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2–EED PPI. …”

Image_6_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_5_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_1_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Table_2_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.pdf by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_2_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_4_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Table_1_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.pdf by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_3_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Forest plot. by Junyin Pan (20700411)

Dynamics of heavy metals in the fine sediments from a subtropical forest headwater stream during a rainy season by Zemin Zhao (7387283)

“…We found that (1) the mean storage of fine sediment of heavy metals was ordered Mn (21.57 g m⁻²) > Pb (2.53 g m⁻²) > Zn (2.27 g m⁻²) > Cr (0.66 g m⁻²) > Cu (0.12 g m⁻²) > Cd (0.006 g m⁻²); (2) their storage had a transient increase during the rainy season, followed by a decrease, but storage of both Zn and Cr was unevenly distributed from stream source to mouth; and (3) the key factors controlling heavy metal storage were water alkalinity, temperature, and pH, as well as monthly precipitation. …”

The Potential Impact of a 20% Tax on Sugar-Sweetened Beverages on Obesity in South African Adults: A Mathematical Model by Mercy Manyema (618205)

“…The number of obese adults would decrease by over 220 000 (95% CI: 24 197–411 759).</p><p>Conclusions</p><p>Taxing SSBs could impact the burden of obesity in South Africa particularly in young adults, as one component of a multi-faceted effort to prevent obesity.…”

Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice by Jung Hun Ohn (10089)

“…According to microarray analysis, genes regulated by PPARγ1 and PPARα were down-regulated in myocardia of SHP KO mice compared to their expression in WT mice after HFD, suggesting that the reduction in lipid accumulation in the myocardium resulted from a decrease in lipogenesis regulated by PPARγ. We confirmed the reduced expression of PPARγ1 and PPARα target genes such as CD36, medium-chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, and very long-chain acyl-CoA dehydrogenase by SHP KO after HFD.…”

Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes by Semira Gonseth (665194)

“…We measured genome-wide DNA methylation from neonatal blood spots. We implemented a method based on bootstrap resampling to decrease false-positive findings. …”

(a) Coastline length changes in the Caspian Sea; (b) LSI changes between 1985 and 2023 (P1 = 1985–1990, P2 = 1990–1995, P3 = 1995–2000, P4 = 2000–2005, P5 = 2005–2010, P6 = 2010–20... by Zihao Duan (17403792)

The transition state in a transitory landscape. by Rowan D. Brackston (5774213)

“…<p>(A) The variance of the transcription levels across 10,000 simulations in which <i>L</i> is linearly decreased with time as <i>L</i> = 150(1 − <i>t</i>); (B) Probability distributions of the transcription levels at three different values of <i>L</i>. …”

Number of anti-viral episodes with drug (A) and ratio of episodes to averted cases(B), assuming constant effective coverage (0.81) and delay (7 days), applied early (day = 1) in an... by Yalda Jafari (382505)