Identification of New Resistance Mechanisms in <i>Escherichia coli</i> against Apidaecin 1b Using Quantitative Gel- and LC–MS-Based Proteomics by Rico Schmidt (1576480)

“…Antimicrobial peptides identified in insects, animals, and plants represent a huge pool of promising lead structures that can be further developed for medical applications. …”

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt by Frank A. Suprynowicz (4237495)

“…Active Akt actually decreases due to increased mTOR signaling, with a consequent increase in dephosphorylated, active GSK-3. …”

Data_Sheet_1_Intranasal Peptide-Based FpvA-KLH Conjugate Vaccine Protects Mice From Pseudomonas aeruginosa Acute Murine Pneumonia.docx by Emel Sen-Kilic (5868818)

“…Immunization with the FpvA-KLH vaccine decreased the bacterial burden and lung edema after P. aeruginosa challenge. …”

Brpf1 loss compromises neural stem cells and neuronal precursors. by Linya You (700541)

“…<p>(A-C) Immunofluorescence microscopy to detect Sox2⁺ neural stem cells (NSCs) on peri- or postnatal brain sections. …”

Defective Tbr2⁺ and NeuroD1⁺ neuronal precursors in the mutant hippocampus. by Linya You (700541)

“…<p>(A-D) Immunostaining to detect Tbr2⁺ intermediate neuronal progenitors on sections from E13.5, E16.5, P0 and P10 brains. …”

Impaired muscle function in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice. by S. Pasteuning-Vuhman (4348486)

“…<p><b>(a)</b> A lower body weight (<i>P</i><0.01) was detected in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice when compared to wild type mice. …”

Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure by Marco Maccarana (429522)

“…The glycosaminoglycan content and structure in <i>Aspn</i>^<i>-/-</i> skin was profoundly altered: chondroitin/dermatan sulfate was more than doubled and had an altered composition, while heparan sulfate was halved and had a decreased sulfation. Also, decorin and biglycan were doubled in <i>Aspn</i>^<i>-/-</i> skin. …”

Quantifying time concordance based on first activation. by Anika Liu (8411805)

Image_1_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

DataSheet_1_Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency.docx by Federica Pulvirenti (8262402)

“…</p>Conclusions<p>CVID patients showed a perturbed oropharynx microbiota enriched with potentially pathogenic bacteria and decreased protective species. …”

Image_1_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.jpg by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

Data_Sheet_1_Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (ass... by Jing Li (10611)

“…We found that the HBB −28(A>G) mutation not only disturbed the transcription of HBB, but also decreased the expression of HBG, which may further aggravate the thalassemia phenotype and partially explain the more severe clinical outcome of β-thalassemia patients with the HBB −28(A>G) mutation. …”

Image_2_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.jpg by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

Image_3_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

Image_2_Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis.TIFF by Yingzhao Liu (8959862)

“…Interestingly, knockdown of miR-125a-5p in CD4⁺ T cells resulted in an elevated level of MAF but decreased the proportion of Th1 cells and the transcript level of IFN-γ in vitro. …”

Image_3_Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.tif by Mafalda De Rienzo (11312694)

“…Anti-SARS-CoV-2 antibody levels steadily decreased. No correlation was found between anti-S/anti-N IgG and IgM levels and viral NT, measured by either a microneutralization test or the surrogate RBD/ACE2-binding inhibition test. …”

KIRA8 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure. by Maike Thamsen (6191015)

Image_3_CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer.TIF by Yongyuan Chen (8319612)

“…In contrast, the NKG2A⁺ NK cells were decreased in tumors compared with the paired normal lung tissue. …”

Image_2_CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer.TIF by Yongyuan Chen (8319612)

“…In contrast, the NKG2A⁺ NK cells were decreased in tumors compared with the paired normal lung tissue. …”

table_2_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”