Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models by Satish Noonepalle (7344425)

“…<i>In vivo</i> studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances antitumor immune response, mediated by a decrease of protumoral M2 macrophages and increased infiltration of antitumor CD8+ effector and memory T-cells.…”

Schematic representation of podoplanin pull-down by Fc-CLEC-2 and protein A beads and subsequent slot blot analysis. by Nobuo Watanabe (845921)

“…If a test compound inhibits the interaction between Fc moiety and protein A, slot intensity for Fc-CLEC-2 is expected to decrease.…”

Ferrocenyl-Imidazolylidene Ligand for Redox-Switchable Gold-Based Catalysis. A Detailed Study on the Redox-Switching Abilities of the Ligand by Susana Ibáñez (1607290)

“…The analysis of the electron-donating character of the neutral ligand and the ligand resulting from the oxidation was carried out by studying the variation of the ν­(CO) stretching frequencies of Fc-NHC-IrCl­(CO)₂ and its oxidized analogue, revealing that this shift is 2.9 cm^–1, which is consistent with a decrease of the electron-donating character of the ligand produced by the generation of a positively charged metal complex. …”

Image_1_Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling.PDF by Fiete Haack (707641)

“…<p>Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. …”

Commercial impact of adding real-world evidence to clinical trials at regulatory approval: a Markovian-like transition model by Ravi Jandhyala (8494437)

“…<p>Regulatory use of real-world evidence (RWE) has been recognized as a useful supplement to clinical trial evidence and could benefit patients by reducing time to treatment. …”

Biofilm imaging using wheat germ agglutinin (WGA) shows a loss of VPS following RbmB incubation. by Ranjuna Weerasekera (20371182)

“…The WGA signal remained strong in the Δ<i>rbmB</i> mutant biofilms (top row), while addition of 50 μg/mL RbmB led to a decrease in the WGA signal (middle row). The lower row shows the same experiment with the wild-type strain. …”

Genetic Analysis of Baker's Yeast Msh4-Msh5 Reveals a Threshold Crossover Level for Meiotic Viability by K. T. Nishant (13769)

“…The <em>msh4/5-t</em> mutants also displayed synaptonemal complex assembly defects. A triple mutant containing a <em>msh4/5-t</em> allele and mutations that decreased meiotic double-strand break levels (<em>spo11-HA</em>) and crossover interference (<em>pch2Δ</em>) showed synergistic defects in spore viability. …”

Table_1_Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study.xls by Deyang Liu (12256569)

“…Background<p>Observational studies have reported a strong association between autistic spectrum disorder (ASD) and intestinal metabolites. …”

Table_1_Alleviation of DSS-induced colitis in mice by a new-isolated Lactobacillus acidophilus C4.PDF by Qianqian Liu (381114)

Image_1_Alleviation of DSS-induced colitis in mice by a new-isolated Lactobacillus acidophilus C4.PDF by Qianqian Liu (381114)

Effect of Thermal Treatment on the Dynamic Behaviors at a Fixed Loading Rate of Limestone in Quasi-vacuum and Air-filled Environments by Liyuan Yu (5341841)

“…However, in the second stage, with temperatures ranging from 450°C to 900°C, the thermal damage caused by mineral decomposition and hydration leads to a remarkable decrease in the dynamic bearing and anti-deformation capacities. …”

Disruption of DNA Methylation via <i>S</i>‑Adenosylhomocysteine Is a Key Process in High Incidence Liver Carcinogenesis in Fish by Leda Mirbahai (1832740)

“…The mechanism of this disruption is linked not to depletion of <i>S</i>-adenosylmethionine, as is often a feature of mammalian tumors, but to a decrease in choline and elevated <i>S</i>-adenosylhomocysteine, a potent inhibitor of DNA methyltransferase. …”

Impacts of anthropogenic emission change scenarios on U.S. water and carbon balances at national and state scales in a changing climate by Libo Zhang (22078106)

“…This study investigates the ecohydrological responses to the individual and combined impacts of climate change and anthropogenic emission changes at two spatial scales by coupling a regional online-coupled meteorology and chemistry model (WRF-Chem) and a water balance model (WaSSI). …”

Short-term high-fat diet affects macrophages inflammatory response, early signs of a long-term problem by Ed Wilson Santos (7576457)

“…LPS-stimulated peritoneal macrophages from HFD-treated animals showed a reduction in mRNA expression of TNF-α and IL-6, as well as a decrease in expression of the transcription factor nuclear factor-kappa B (NF-kB). …”

Image_2_Interleaved configurations of percutaneous epidural stimulation enhanced overground stepping in a person with chronic paraplegia.TIF by Ashraf S. Gorgey (5706617)

“…After 6 months, interleaving the original rhythmic-SCES with an additional configuration (−12, +15) on the opposite lead, resulted in a decrease of the extensive adduction tone and allowed the participant to initiate overground stepping up to 16 consecutive steps. …”

Image_2_Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling.pdf by Fiete Haack (707641)

“…<p>Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. …”

A Wearable, Humidity-Resistant Triboelectric Nanogenerator Based on Hydrophobic Leather for Human Motion Monitoring and Sign Language Recognition by Rui Sun (177521)

“…The WPL-TENG maintained a stable output voltage of ∼57 V across −10 to 98 °C, with only a 2% decrease in output voltage when humidity increased from 28% to 86%. …”

Supplementary Material for: Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial by Kanti V. (3748321)

“…In group C, TEWL remained stable; in group SSO, TEWL increased significantly on the abdomen, leg and buttock until day 11, followed by a decrease after SSO application had been stopped. …”

Resilient Plant–Bird Interactions in a Volcanic Island Ecosystem: Pollination of Japanese Camellia Mediated by the Japanese White-Eye by Harue Abe (408536)

“…The results showed that despite a decrease in <i>Camellia</i> flowers, the partitioning of allelic richness among mother-tree pollen pools and seeds decreased while the migration rate of pollen from outside the study plot and the pollen donor diversity within a fruit increased as the index of volcanic damage increased. …”

Table_1_Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study.DOCX by Yanmei Feng (5224850)

“…Introduction<p>There is a high incidence of both smoking and tuberculosis (TB) in China. …”