Tandem Mass Tag-Based Serum Proteome Profiling for Biomarker Discovery in Young Duchenne Muscular Dystrophy Boys by Tchilabalo D. Alayi (9465034)

“…In this study, we have standardized a highly specific and reproducible multiplexing mass spectrometry method using the tandem mass tag (TMT) strategy in combination with depletion of abundant proteins from serum and high-pH reversed-phase peptide fractionation. …”

Data_Sheet_1_The Relationship Between Lava Fountaining and Vent Morphology for the 2014–2015 Holuhraun Eruption, Iceland, Analyzed by Video Monitoring and Topographic Mapping.PDF by Tanja Witt (6092753)

“…Here we analyze records from lava fountain activity at distinguished vents, captured during the 2014–2015 Holuhraun eruption, and compare them with the morphology of spatter cones that developed. We conducted a fieldwork mapping project combining terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) aerophoto techniques to characterize the cone morphologies. …”

Association of Nd:YAG laser and calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion by Vinícius MAXIMIANO (12833560)

“…Methodology Dentin specimens were exposed to 17% ethylene diamine tetra-acetic acid (EDTA) solution for 5 min and randomly allocated into five groups: G1, control (no treatment); G2, Nd:YAG laser (1 W, 10 Hz, 100 mJ, 85 J/cm2); G3, Laser + TeethmateTM Desensitizer; G4, Laser + Desensibilize Nano P; and G5, Laser+Nupro®. Specimens underwent a 5-day erosion-abrasion cycling. Hydraulic conductance was measured post-EDTA, post-treatment, and post-cycling. …”

Data_Sheet_3_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.PDF by Jiarui Mi (11170284)

“…</p>Results<p>In the primary analysis with 249 traits, we found that plasma triglycerides were positively associated with pancreatitis risk. Intriguingly, a large number of traits associated with saturation or unsaturation of fatty acids also demonstrated causal associations. …”

Table_3_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota-Gut-... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Table_1_Comparative analyses of functional traits based on metabolome and economic traits variation of Bletilla striata: Contribution of intercropping.xlsx by Pengfei Deng (14806162)

“…<p>The intercropping practice has been regarded as a practical land-use selection to improve the management benefits of Bletilla striata plantations. …”

Dirhodium Complexes Bridged by Bis(diphenylphosphino)phthalazine (PNNP^Ph): Central Ring Size and Charge Effects As Compared with the Pyrazolate Derivative (PNNP<sup>Py</... by Takafumi Yamaguchi (2244949)

“…A dirhodium carbonyl complex with 1,4-bis((diphenylphosphino)methyl)phthalazine (PNNP^Ph), [(μ-κ²:κ²-PNNP^Ph){Rh(CO)}₂](BF₄)₂, has been prepared and its reactivity studied as compared with the previously reported 3,5-bis((diphenylphosphino)methyl)pyrazolate (PNNP^Py) analogue [(μ-κ²:κ²-PNNP^Py){Rh(CO)₂}₂]BF₄. …”

Alumazene Adducts with Pyridines:  Synthesis, Structure, and Stability Studies by Jiri Löbl (2485519)

“…The planarity of the alumazene ring is lost upon coordination of the Lewis base molecules. A comparison of the Al−N(base) bond distances and pyramidality at Al suggests the higher basicity of dmap. …”

Data_Sheet_1_Altered Brain Structure in Chronic Visceral Pain: Specific Differences in Gray Matter Volume and Associations With Visceral Symptoms and Chronic Stress.pdf by Hanna Öhlmann (11584672)

“…Associations between visceral symptoms and GMV within frontal regions were altered in both patient groups, supporting a role of the central executive network across visceral pain conditions. …”

Table_4_Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.XLSX by Ya-nan Mo (11829002)

“…<p>The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. …”

Image_5_Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.TIF by Yue Zheng (601811)

“…The hub DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the expressions of hub DEMRGs were analyzed using the GSE135055 and GSE116250 datasets as well as atherosclerosis and MI mice model.</p>Results<p>A total of 509 differentially expressed genes (DEGs) were correlated with the abundance of macrophages and were identified as DEMRGs (Pearson correlation coefficients (PCC) > 0.6), which were mainly enriched in extracellular structure organization, lysosomal membrane, MHC protein complex binding, and so on. …”

Image_4_Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.TIF by Yahui Feng (3897082)

“…</p>Methods<p>The domain mutants CHK25 (^ΔS_TkcCHK1/Δchk1) and CHK26 (^ΔS_TkcΔgafCHK1/Δchk1) were first constructed by the his1-URA3-his1 method and confirmed by sequencing and Southern blots. A mouse tongue infection model was used to evaluate the hyphal invasion and fungal loads in each domain mutant, full-gene deletion mutant CHK21 (chk1Δ/chk1Δ), re-constituted strain CHK23 (chk1Δ/CHK1), and wild type (WT) from day 1 to day 5. …”

Image1_G Protein–Coupled Estrogen Receptor 30 Reduces Transverse Aortic Constriction–Induced Myocardial Fibrosis in Aged Female Mice by Inhibiting the ERK1/2 -MMP-9 Signaling Pathw... by Xiaowu Wang (167537)

“…G protein–coupled estrogen receptor 30 (GPR30) is a membrane receptor of estrogen and displays protective roles in diverse cardiovascular diseases. …”

Image2_Comprehensive analysis of m7G modification patterns based on potential m7G regulators and tumor microenvironment infiltration characterization in lung adenocarcinoma.TIF by Shouzheng Ma (12264398)

“…Nonetheless, the potential regulatory role of N7-methylguanosine (m⁷G) modification in shaping and impacting the TME remains unclear.</p><p>Methods: A comprehensive analysis was performed to explore the m⁷G modification patterns based on 24 potential m⁷G regulators in 817 lung adenocarcinoma (LUAD) patients, and the TME landscape in distinct m⁷G modification patterns were evaluated. …”

Image_5_Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation.tiff by Xinxu Yuan (7446968)

“…Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1β-containing EVs in ECs. Using a Western diet (WD)-induced hypercholesterolemia mouse model, we found that endothelial-specific AC gene knockout mice (Asah1^fl/fl/EC^Cre) exhibited augmented WD-induced EV secretion with IL-1β and more significantly decreased the interaction of MVBs with lysosomes in the carotid arterial wall compared to their wild-type littermates (WT/WT). …”

DataSheet1_N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis.docx by Ji Eun Kim (403026)

“…<p>As our previous study revealed that N-benzyl-N-methyldecan-1-amine (BMDA), a new molecule originated from Allium sativum, exhibits anti-neoplastic activities, we herein explored other functions of the compound and its derivative [decyl-(4-methoxy-benzyl)-methyl-amine; DMMA] including anti-inflammatory and anti-oxidative activities. …”

DataSheet1_Improper preanalytical processes on peripheral blood compromise RNA quality and skew the transcriptional readouts of mRNA and LncRNA.DOCX by Yinli He (14323689)

“…In this study, we explored the impact of RNA extraction kits and timing of blood placement on peripheral blood leukocyte-derived RNA quality. A novel enhanced evaluation system including RNA yields, purity, RNA integrity number (RIN) values and β-actin copies was employed to more sensitively identify RNA quality differences. …”

DataSheet1_The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Can... by Changping Deng (11894321)

“…In order to explore the specific functions of BIRC5 gene in multi-drug resistance (MDR), a CRISPR/Cas9-mediated knocking-in tetracycline (Tet)-off regulatory system cell line was established, which enabled us to regulate the expression levels of Survivin quantitatively (clone 8 named MCF-7/Survivin was selected for further studies). …”

Table 2_Global burden and future trends of gastric cancer in women of reproductive age: estimates from the GBD 2021 Study, 1990–2050.xlsx by Nan Jiang (21252)

“…Although incidence is higher in men, GC remains a significant health issue for women of reproductive age (15–49 years) due to biological, hormonal, and socioeconomic factors. …”

Image_7_Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.TIFF by Yue Zheng (601811)

“…The hub DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the expressions of hub DEMRGs were analyzed using the GSE135055 and GSE116250 datasets as well as atherosclerosis and MI mice model.</p>Results<p>A total of 509 differentially expressed genes (DEGs) were correlated with the abundance of macrophages and were identified as DEMRGs (Pearson correlation coefficients (PCC) > 0.6), which were mainly enriched in extracellular structure organization, lysosomal membrane, MHC protein complex binding, and so on. …”