Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway by Junyu Lin (529231)

“…While the dimerization domain of HNF1α was dispensable for the induction of LHBs expression, all the domains of HNF1α was required for the inhibition of HBV gene expression. Our findings identify a novel role of HNF1α in the regulation of HBV gene expression and replication.…”

Subcellular localization and protein level of APC in wild type and <i>Cep290</i> KO cells. by Kazuhiko Matsuo (2880248)

“…<p>(A) The subcellular localization of APC at the leading edge was assessed in wild type and <i>Cep290</i> KO cells. …”

Data_Sheet_1_New Insights Into Lignification via Network and Multi-Omics Analyses of Arogenate Dehydratase Knock-Out Mutants in Arabidopsis thaliana.zip by Kim K. Hixson (236908)

“…While prior work helped explain lignin biosynthesis regulation at the transcriptional level, our data here provide support for a new hypothesis that there are additional post-transcriptional and translational level processes that need to be considered. …”

Data_Sheet_1_ZmPP2C26 Alternative Splicing Variants Negatively Regulate Drought Tolerance in Maize.DOCX by Fengzhong Lu (12373204)

“…In this study, we characterized a clade B member of maize PP2C family, i.e., ZmPP2C26, that negatively regulated drought tolerance by dephosphorylating ZmMAPK3 and ZmMAPK7 in maize. …”

Organophosphine Oxide/Sulfide-Substituted Lanthanide Binaphtholate Catalysts for Enantioselective Hydroamination/Cyclization by Xianghua Yu (2302027)

“…A series of chiral organophosphine oxide/sulfide-substituted binaphtholate ligands have been prepared ({(<i>R</i>)-H₂BINOL-[P(O)R₂]₂}^2-, R = Ph, Et, <i>^t</i>Bu, 3,5-xylyl, Bn, and OEt; {(<i>R</i>)-H₂BINOL-[P(S)Ph₂]₂}^2-). …”

Covalent Immobilization of Caged Liquid Crystal Microdroplets on Surfaces by Xuanrong Guo (1465693)

“…Our results address practical issues associated with the preparation, characterization, storage, and point-of-use application of conventional LC-in-water emulsions and provide a basis for approaches that could enable the development of new “off-the-shelf” LC droplet-based sensing platforms.…”

Table_1_Vaginal Microbiome Signature Is Associated With Spontaneous Preterm Delivery.XLSX by Keli Hočevar (6398501)

“…</p><p>Results: Women who experienced PTD had a higher microbial richness (Chao1, P = 0.011) and alpha diversity (Shannon, P = 0.00059) than women with term deliveries. …”

Data_Sheet_3_Metabolomics combined with intestinal microbiota reveals the mechanism of compound Qilian tablets against diabetic retinopathy.PDF by Jiangwei Jia (19431646)

“…Compound Qilian tablets (CQLT) is a traditional Chinese medicine (TCM) developed for treating DR, but its mechanism is still unclear. …”

Table_5_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…</p>Results<p>In the primary analysis with 249 traits, we found that plasma triglycerides were positively associated with pancreatitis risk. Intriguingly, a large number of traits associated with saturation or unsaturation of fatty acids also demonstrated causal associations. …”

Image_4_Wheat F-box Protein TaFBA1 Positively Regulates Plant Drought Tolerance but Negatively Regulates Stomatal Closure.tif by Jie An (543888)

“…In addition, TaFBA1 was found to be a negative regulator of ABA-induced stoma movement; mRNA transcription of certain ABA signaling-related genes was lower in TaFBA1 OE plants than in WT plants following ABA treatment. …”

Data_Sheet_5_E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway.ZIP by Zhi Liu (165121)

“…<p>Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. …”

Supplementary Material for: Downregulation of Signal Transducer and Activator of Transcription 4 (STAT4) contributes to impaired osteogenic differentiation of human bone marrow ste... by figshare admin karger (2628495)

“…This study provides insight into the molecular mechanisms underlying the loss of osteogenic differentiation during hBMSC expansion and identifies STAT4 as a potential target for hBMSC-based bone regeneration therapies.…”

DataSheet1_Clostridium butyricum Protects Against Pancreatic and Intestinal Injury After Severe Acute Pancreatitis via Downregulation of MMP9.ZIP by Qingqing Yan (752158)

“…In addition, to investigate the association between gut microbiota and MMP9 in intestinal injury during SAP, we established MMP9 stable knockdown Caco2 and HT29 cells in vitro and generated a MMP9 knockout (MMP9−/−) mouse model of SAP in vivo.…”

Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells by Lan Yu (346201)

“…Consistent with this, the average number of TUNEL⁺ and cleaved caspase-3⁺ apoptotic intestinal epithelial cells were significantly increased after OH-GQDs treatment. Finally, a 3-dimensional organoid culture was established using isolated crypts, and OH-GQDs treatment significantly reduced the size of the surviving intestinal organoids. …”

DataSheet_1_KMT2D regulates activation, localization, and integrin expression by T-cells.docx by Sarah J. Potter (18498468)

“…Using high-throughput RNA-sequencing and flow cytometry, we reveal decreased expression (both at the transcriptional and translational levels) of a cluster of leukocyte-specific integrins, which perturb aspects of T-cell activation, maturation, adhesion/localization, and effector function. …”

Table_1_Tracing the Atmospheric Input of Seawater-Dissolvable Pb Based on the Budget of 210Pb in the East Sea (Japan Sea).xlsx by Hojong Seo (11067672)

“…The vertical profiles of total ²¹⁰Pb and dissolved Pb generally showed a surface maximum and then decreased with depth. …”

DataSheet1_Ablation Patterns of the Debris Covered Tongue of Halong Glacier Revealed by Short Term Unmanned Aerial Vehicle Surveys.docx by Wanqin Guo (450937)

“…The surface ablation rates show a clear negative exponential relationship with the measured debris thicknesses, well in accordance with previous studies. …”

Image_1_MicroRNA-122-5p Inhibition Improves Inflammation and Oxidative Stress Damage in Dietary-Induced Non-alcoholic Fatty Liver Disease Through Targeting FOXO3.pdf by Yiyi Hu (433827)

“…This study provides a novel finding that FOXO3 was the target gene of miR-122-5p to attenuate inflammatory response and oxidative stress damage in dietary-induced NAFLD. …”

Image 4_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Table_1_Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-κ B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways... by Jin-Hua Tao (5496602)

“…Meanwhile, the elevated expression levels of pp65, TLR4, p-STAT3, and p-JAK2 were significantly decreased after treatment. Results suggested that CP would be a potential prebiotics for alleviation of TNBS-induced colitis. …”