Video_8_Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.AVI by Martin Vielreicher (10957656)

“…Multiphoton Second Harmonic Generation (SHG) microscopy, is able to visualize the sterical topology of the collagen-I fibrillar network in 3D, in a minimally invasive and label-free manner. Penetration depths exceed those of conventional visible light imaging and can be further optimized through employing decalcification or optical clearing processing ex vivo. …”

Extreme Low-Temperature Combustion Chemistry: Ozone-Initiated Oxidation of Methyl Hexanoate by Aric C. Rousso (5872646)

“…The accelerating chemical effect of ozone addition on the oxidation chemistry of methyl hexanoate [CH₃(CH₂)₄C­(O)­OCH₃] was investigated over a temperature range from 460 to 940 K. Using an externally heated jet-stirred reactor at <i>p</i> = 700 Torr (residence time τ = 1.3 s, stoichiometry φ = 0.5, 80% argon dilution), we explored the relevant chemical pathways by employing molecular-beam mass spectrometry with electron and single-photon ionization to trace the temperature dependencies of key intermediates, including many hydroperoxides. …”

Cholesterol Selectively Regulates IL-5 Induced Mitogen Activated Protein Kinase Signaling in Human Eosinophils by Mandy E. Burnham (615356)

“…Formation of these organizational membrane domains is in turn dependent upon the amount of available cholesterol, which can fluctuate widely with a variety of disease states. We tested the hypothesis that manipulating membrane cholesterol content in primary human peripheral blood eosinophils (PBEos) would selectively alter signaling pathways that depend upon membrane-anchored signaling proteins localized within CRMMs (<i>e.g.…”

Image_5_Single cell analysis of short-term dry eye induced changes in cornea immune cell populations.jpg by Jehan Alam (5577734)

“…Significant changes in expression of 1,365 genes (adj p < 0.0001) were noted in rMP with increases in cytokines and chemokines (Tnf, Cxcl1, Ccl12, Il1rn), inflammatory markers (Vcam, Adam17, Junb), the TAM receptor (Mertk), and decreases in complement and MHCII genes. A differentiation trajectory from monocytes to terminal state rMP was found. …”

Image_1_Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells.TIF by Melissa M. McGovern (5173304)

“…Specifically, Atoh1-CreER^TM::Rosa26^{loxP-stop-loxP-DTA/}⁺::Sox10^rtTA::TetO-LacZ::TetO-N1ICD mice were injected with tamoxifen at P0/P1 to stimulate spontaneous HC regeneration and given doxycycline from P0–P7 to induce expression of N1ICD as well as LacZ for fate-mapping. We observed a 92% reduction in the number of fate-mapped regenerated HCs in mice with N1ICD overexpression compared to controls with HC damage but no manipulation of Notch signaling. …”

DataSheet_2_The Efficacy and Safety of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Combined With Thymosin in Advanced Non-Small Cell Lung Cancer Patients Harboring A... by Yongdong Feng (10891662)

“…</p>Conclusions<p>Combination of EGFR-TKI and thymosin can significantly prolong the PFS and OS compared with EGFR-TKI monotherapy without more adverse events, which offers a new strategy in clinic.</p>…”

DataSheet_1_Seasonal decline in leaf photosynthesis in perennial switchgrass explained by sink limitations and water deficit.docx by Mauricio Tejera-Nieves (14324832)

“…We tested the association of seasonal photosynthetic decline in switchgrass (Panicum virgatum L.) with water availability by comparing plants experiencing ambient rainfall with plants in a rainfall exclusion experiment in Michigan, USA. …”

Image3_Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.jpeg by Taiki Sato (394623)

“…Accumulating evidence indicates a crucial role for interleukin-9 (IL-9) in the formation of germinal centers (GCs), enhancing the generation of class-switched high-affinity antibodies. …”

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism by Mayumi Nakahara (464598)

“…This study was designed to elucidate the cellular and molecular basis of histone-induced lethality and to assess the protective effects of recombinant thrombomodulin (rTM). rTM has been approved for the treatment of disseminated intravascular coagulation (DIC) in Japan, and is currently undergoing a phase III clinical trial in the United States.…”

DataSheet_1_Gut microbes improve prognosis of Klebsiella pneumoniae pulmonary infection through the lung-gut axis.pdf by Yuxiu Tang (18767059)

“…Background<p>The gut microbiota plays a vital role in the development of sepsis and in protecting against pneumonia. …”

Table_11_Physio-biochemical and transcriptomic analysis of Bacillus amyloliquefaciens PG-4-induced salt stress tolerance in Macrotyloma uniflorum.DOCX by Yanna Wu (7675676)

“…</p>Results<p>In presence of different salt levels, PG-4 showed a high potentiality to produce several plant growth promoting metabolites such as NH₃, siderophore, 1-aminocyclopropane-1-carboxylic acid deaminase (ACC-deaminase), and hydrolytic enzymes. …”

Table_4_Metagenome Analysis of Intestinal Bacteria in Healthy People, Patients With Inflammatory Bowel Disease and Colorectal Cancer.xlsx by Yongshun Ma (9737837)

“…Objectives<p>Several reports suggesting that the intestinal microbiome plays a key role in the development of inflammatory bowel disease (IBD) or colorectal cancer (CRC), but the changes of intestinal bacteria in healthy people, patients with IBD and CRC are not fully explained. …”

Table_3_Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics.csv by Yongguang Liu (5800769)

“…When the dose of immunosuppressant is too low, graft rejection occurs easily, while a dose that is too high can lead to graft loss. …”

Image_3_Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo.TIF by Veronika Marek (6725135)

“…The only drug that significantly decreased the blue-light aversion was the intraperitoneally injected melanopsin antagonist. …”

Data Sheet 1_MIKC-type MADS-box transcription factor OsMADS31 positively regulates salinity tolerance in rice.pdf by Xiaolin Yin (359202)

“…<p>Rice (Oryza sativa L.) is one of the world’s most vital staple crops, providing food for over 50% of the global population. As a salt-sensitive crop, rice is susceptible to damage from soil-soluble salt stress, which can severely reduce rice yield. …”

Table_6_Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics.csv by Yongguang Liu (5800769)

“…When the dose of immunosuppressant is too low, graft rejection occurs easily, while a dose that is too high can lead to graft loss. …”

Data Sheet 2_Global, regional and national mortality burden of laryngeal cancer attributable to occupational exposure to sulfuric acid and asbestos: 1990–2021 and projections to 20... by Xin Gong (592328)

“…Occupational exposure to sulfuric acid (OESA) and asbestos (OEA) is a recognized risk factor for LC, but the associated mortality burden remains unclear. …”

Table 1_Global, regional, and national trends in DALYs for blindness and vision loss in teenagers and young adults, 1990–2019: an age-period-cohort analysis based on the Global Bur... by Juan Lu (275293)

“…The APC model estimated a global net drift at −0.43% (95% CI: −0.45% to −0.42%) per year, ranging from −0.92% (95% CI: −0.94% to −0.91%) in low-middle socio-demographic Index (SDI) regions to −0.03% (95% CI: −0.07% to −0.0005%) in high SDI regions. …”

Image_6_Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia–reperfusion injury based on integrating fecal metabonomics and 16S rDNA... by Ximeng Ding (14018481)

“…The present study has shown a significant effect of G. elata Blume in improving cerebral ischemia–reperfusion injury (CIRI). …”

Table2_Network Pharmacology-Based Strategy for the Investigation of the Anti-Osteoporosis Effects and Underlying Mechanism of Zhuangguguanjie Formulation.XLSX by Wang Gong (11510329)

“…The ovariectomized (OVX) mice were treated with normal saline or ZG for 4 weeks after ovariectomy following a series of analyses. The bone mass density (BMD) and trabecular parameters were examined by micro-CT. …”