<i>Spirodela polyrhiza</i> extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation by Joo Hyun Nam (190369)

“…Ion channel modulation in transfected HEK293T cells was measured using a conventional whole-cell patch-clamp technique. …”

DataSheet4_Guanxinkang Decoction Attenuates the Inflammation in Atherosclerosis by Regulating Efferocytosis and MAPKs Signaling Pathway in LDLR−/− Mice and RAW264.7 Cells.ZIP by Yifan Zhang (119570)

“…<p>Guanxinkang decoction (GXK), a traditional Chinese medicinal drug, is used to treat cardiovascular disease. …”

Table_4_Preliminary prediction of semen quality based on modifiable lifestyle factors by using the XGBoost algorithm.docx by Mingjuan Zhou (12880019)

“…Then, machine learning with the XGBoost algorithm was applied to establish a primary prediction model by using the collected data. …”

DataSheet5_Guanxinkang Decoction Attenuates the Inflammation in Atherosclerosis by Regulating Efferocytosis and MAPKs Signaling Pathway in LDLR−/− Mice and RAW264.7 Cells.ZIP by Yifan Zhang (119570)

“…<p>Guanxinkang decoction (GXK), a traditional Chinese medicinal drug, is used to treat cardiovascular disease. …”

DataSheet_2_GhWRKY70D13 Regulates Resistance to Verticillium dahliae in Cotton Through the Ethylene and Jasmonic Acid Signaling Pathways.xlsx by Xiang-Peng Xiong (8487657)

“…<p>Verticillium wilt caused by Verticillium dahliae is a destructive cotton disease causing severe yield and quality losses worldwide. …”

SIRT3 mediates the PGC-1α induction of mitochondrial-related genes in C₂C₁₂ skeletal muscle cells. by Xingxing Kong (363056)

“…<p><b>A</b>, Knockdown of mSIRT3 protein level with shRNA in C₂C₁₂ myotubes. …”

Image_4_Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation.tiff by Xinxu Yuan (7446968)

“…Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1β-containing EVs in ECs. Using a Western diet (WD)-induced hypercholesterolemia mouse model, we found that endothelial-specific AC gene knockout mice (Asah1^fl/fl/EC^Cre) exhibited augmented WD-induced EV secretion with IL-1β and more significantly decreased the interaction of MVBs with lysosomes in the carotid arterial wall compared to their wild-type littermates (WT/WT). …”

Image_7_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.tif by Hongmei Li-Byarlay (5227208)

“…Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. …”

Effect of ice slushy ingestion and cold water immersion on thermoregulatory behavior by Hui C. Choo (6407807)

“…Both precooling treatments attenuated the thermal efferent signals until a specific body temperature threshold was reached.…”

DataSheet1_Cross-Shore Environmental Gradients in the Western Mediterranean Coast and Their Influence on Nearshore Phytoplankton Communities.docx by Gotzon Basterretxea (418508)

“…Most intense physical and biological anomalies along these transects were generally constrained to the first hundred meters from the shoreline (i.e., a transition zone starting at ~400 m). We use Principal Component Analysis (PCA) and k-means cluster analysis to categorize temperature, salinity and chlorophyll (T, S and Chl) in three main types of cross-shore trends. …”

DataSheet1_Comprehensive analysis of m7G modification patterns based on potential m7G regulators and tumor microenvironment infiltration characterization in lung adenocarcinoma.doc... by Shouzheng Ma (12264398)

“…Nonetheless, the potential regulatory role of N7-methylguanosine (m⁷G) modification in shaping and impacting the TME remains unclear.</p><p>Methods: A comprehensive analysis was performed to explore the m⁷G modification patterns based on 24 potential m⁷G regulators in 817 lung adenocarcinoma (LUAD) patients, and the TME landscape in distinct m⁷G modification patterns were evaluated. …”

DataSheet1_Effects of Leydig cell elimination on testicular interstitial cell populations: characterization by scRNA-seq and immunocytochemical techniques.docx by Fu Huang (1711924)

“…Some of the rats were also treated with a dose of ethylenedimethylsulfonate (EDS) to examine how the loss of Leydig cells (LCs) could affect interstitial homeostasis for three weeks.…”

Image_6_Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.jpeg by Camille Couture (18464808)

“…Furthermore, changes in immune cell populations, as well as cytokine production by CD14+, CD4+, and CD8+ cells, suggested a dampened response with an exhausted phenotype including decreased IL1β, IL12, and IFNγ as well as elevated IL10. …”

FUNDC1 mediated mitochondria-dependent ferroptosis of epithelial cells in model of asthma by FBXL2/ar/GPX4 signaling pathway of SUMO1 at K136 by Li Li (14993)

“…FBXL2, ASN-205, GLN-204, ARG-235, and GLN-237 form hydrogen bonds with FUNDC1's ASP-15, ASP-16, GLU-25, and ARG-29, with lengths of 2.3, 3.1, 2.9, 2.3, and 2.9 Å, respectively. The induction of FBXL2 reduced the effects of Sh-FUNDC1 on asthma in mice model of asthma. …”

ULTRASONOGRAPHIC MARKERS OF CARDIOVASCULAR DISEASE RISK IN OBESE CHILDREN by Karla Cristina Malta Costa (5053937)

“…<p></p><p>ASTRACT Objective: To evaluate whether the obesity alters ultrasonographical markers of metabolic and cardiovascular disease risk in children. Methods: A cross-sectional study evaluated 80 children aged between 6 and 10 years, comparing 40 obese with 40 normal children. …”

Table_1_Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle.XLSX by Ya-nan Mo (11829002)

“…<p>The fruits of Ailanthus altissima Swingle (AS) possess a variety of pharmacological activities. Its antioxidant activity and the potential mode of action have not yet been investigated. …”

Table2_Placental circadian lincRNAs and spontaneous preterm birth.xlsx by Guoli Zhou (225819)

“…<p>Long non-coding RNAs (lncRNAs) have a much higher cell- and/or tissue-specificity compared to mRNAs in most cases, making them excellent candidates for therapeutic applications to reduce off-target effects. …”

The metabolic differences between P-LPS and LPS. by Wanyan Li (9741989)

“…Overall, PAMK could alleviate LPS induced intestinal injury by enhancing intestinal barrier function, optimizing gut microbiota composition, and regulating metabolic signaling pathways. Our findings provide a novel strategy for maintaining the intestinal health of poultry and preventing intestinal diseases.…”

DEG conditions and clusters. by Xiaoke Xu (3468623)

“…This infection can lead to neurological effects and establish a viral reservoir. Given the gaps in our understanding of how these cells respond <i>in vivo</i> to acute CNS infection, we conducted single-cell RNA sequencing (scRNA-seq) on myeloid cells from the brains of three rhesus macaques 12 days after SIV infection, along with three uninfected controls. …”

Video_2_Apelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway.AVI by Wenkui Lv (3921323)

“…Atrial electrophysiological mapping was recorded by a 32-electrode microelectrode array. Blood was collected to measure the levels of Ang II and apelin. …”