Image_9_Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease.TIF by Mei-Fang Liu (5966561)

“…The results from animal experiments demonstrated that orexin-A attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. …”

Data Sheet 1_Sleep as a mediator between chronic diseases and depression: a NHANES study (2005–2018).docx by Ming Tan (34506)

“…Additionally, trouble sleeping (OR = 2.059, 95% CI: 1.790, 2.375) was associated with an increased probability of depression, while sleep hours (OR = 0.867, 95% CI: 0.846, 0.888) may decrease this probability. RCS analysis showed a non-linear relationship between sleep hours and the risk of depression. …”

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea by Daouda Sissoko (95574)

“…The objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large Ebola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with EVD. …”

The glycosylated VEGFR2 found upon glucose re-exposure was not a product of a de-novo protein synthesis. by Sirin A. I. Adham (662525)

“…NRP-1 was detected in the same samples as in the previous panel (B) and it did not show a profound decrease in its expression in both MDA-MB-231BO and MDA-MB-231BR. …”

Table1_Biosimilar competition in European markets of TNF-alpha inhibitors: a comparative analysis of pricing, market share and utilization trends.DOCX by Elif Car (15336148)

“…</p><p>Results: Market entry of the first biosimilars of infliximab and adalimumab resulted in a decrease of the volume-weighted average price (VWAP) per DDD by 13.6% and 0.9% on average, whilst the second biosimilars resulted in a decrease by 26.4% and 27.3%, respectively. …”

Effect of a two-stage intervention package on the cesarean section rate in Guangzhou, China: A before-and-after study by Xiaoyan Xia (560153)

“…The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China.…”

Image_1_Microstructural Abnormalities of White Matter Across Tourette Syndrome: A Voxel-Based Meta-Analysis of Fractional Anisotropy.tif by Chengmin Yang (3133929)

“…Meta-regression analysis revealed that age, sex, tic severity, or illness duration of patients with TS were not linearly correlated with decreased FA.</p><p>Conclusion: Patients with TS display deficits of white matter microstructure in the CC and right ILF known to be important for interhemispheric connections as well as long association fiber bundles within one hemisphere. …”

Table_1_Quantifying Ship Strike Risk to Breeding Whales in a Multiple-Use Marine Park: The Great Barrier Reef.docx by Joshua N. Smith (2604571)

“…The multiple-use Great Barrier Reef Marine Park (GBRMP) has recently experienced substantial increases in current and proposed port expansions and subsequent shipping. Globally, large whale populations are recovering from commercial whaling and ship strike is a significant threat to some populations and a potential welfare issue for others. …”

Rare CNVs in Suicide Attempt include Schizophrenia-Associated Loci and Neurodevelopmental Genes: A Pilot Genome-Wide and Family-Based Study by Marcus Sokolowski (3605534)

“…Overall, 45 SA had CNVs enriched for 65 medically relevant genes previously shown to be affected by CNVs, which were characterized by a neurodevelopmental biology. A neurodevelopmental implication was partly congruent with our previous SNP-based GWAS, but follow-up analysis here indicated that carriers of rare CNVs had a decreased burden of common SNP risk-alleles compared to non-carriers. …”

image_4_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_2_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_3_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_5_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_7_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_6_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

image_1_The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.pdf by Melissa N. van Tok (3190323)

“…Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle-treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental SpA. …”

Cesarean section on a rise—Does advanced maternal age explain the increase? A population register-based study by Eva Rydahl (6260771)

“…Given the lack of impact of demographic and health risks on the relationship between maternal age and cesarean section, the authors suggest obstetric culture could be added to the list of risk factors for a cesarean. Future research on obstetric culture is recommended as are studies on a possible age-related decrease in the ability to maintain the progression of labor.…”

Mutations of non-consensus sites also do not affect cell growth or Cdc24 localization, but they further decrease mobility shift of Cdc24. by Stephanie C. Wai (261139)

<i>Bcl2l10</i>, a new <i>Tpx2</i> binding partner, is a master regulator of <i>Aurora kinase A</i> in mouse oocytes by Su-Yeon Lee (378438)

“…<p>Previously, we demonstrated that <i>Bcl-2-like 10</i> (<i>Bcl2l10</i>) is associated with meiotic spindle assembly and that the gene that is most strongly down-regulated by <i>Bcl2l10</i> RNAi is <i>targeting protein for Xklp2</i> (<i>Tpx2</i>). <i>Tpx2</i> is a well-known cofactor that controls the activity and localization of <i>Aurora kinase A</i> (<i>Aurka</i>) during mitotic spindle assembly. …”

Non-monotonic response to regular input spike sequences: increasing the input spike frequency may increase but also decrease the output spike frequency. by Hinrich Arnoldt (688852)