Spinocerebellar ataxia type 11-associated alleles of <i>Ttbk2</i> dominantly interfere with ciliogenesis and cilium stability by Emily Bowie (543704)

“…In this work, we present evidence that SCA11-associated mutations are dominant negative alleles and that the resulting truncated protein (TTBK2^SCA11) interferes with the function of full length TTBK2 in mediating ciliogenesis. A <i>Ttbk2</i> allelic series revealed that upon partial reduction of full length TTBK2 function, TTBK2^SCA11 can interfere with the activity of the residual wild-type protein to decrease cilia number and interrupt cilia-dependent Sonic hedgehog (SHH) signaling. …”

A<i>ß</i> stimulation of platelets induces ROS generation and cell membrane scrambling. by Nina S. Gowert (528687)

“…<p>(A) Generation of ROS from platelets is reported as mean fluorescence intensity (MFI) of DCF. …”

Conflicting selection pressures prevent the outgrowth of TIP-resistant HIV mutants in a host population. by Luke I. Rast (2735782)

“…For example, at <i>P</i> = 2.5, decreasing <i>η</i> results in major increases in transmission from TIP⁺ individuals (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004799#pcbi.1004799.g001" target="_blank">Fig 1B</a>) that overwhelm the modest decreases in transmission from TIP^- individuals, essentially removing the evolutionary conflict at the population-scale. …”

A model of weak compensatory selection predicts the evolutionary dynamics at yeast low occupancy sequences. by Ephraim Kenigsberg (234366)

“…Selection may not be sufficiently powerful to purge every deviation from the optimum and mutations that decrease A/T content may persist (even partially) in the population. …”

Synthesis and Structures of a New Series of Silver-Vanadate Hybrid Solids and Their Optical and Photocatalytic Properties by Haisheng Lin (1487347)

“…Their optical bandgap sizes were measured to be 2.77 eV for <b>I</b>, 2.95 eV for <b>II</b>, and 2.45 eV for <b>III</b>, which decrease most notably as a result of the band widening for the more extended vanadate structure in <b>III</b>. …”

Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial by Beatrice A. Golomb (140574)

“…</p><p>Trial Registration</p><p>Clinicaltrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT00330980" target="_blank">NCT00330980</a></p></div>…”

Correlation analysis between AML cell sensitivity to the four study agents and BH3 profiling using multivariate mixed linear models of both p53 wild-type and p53 mutant cell lines. by Jo Ishizawa (792124)

“…<p>Coefficient β for Nutlin-3a, KPT-330 and Ara-C is positive when the increase of %apoptosis is related to larger %[BH3 peptide], and β for ABT-199 is negative when the decrease of %live cell number is related to larger %[BH3 peptide].…”

LOOCV was implemented in the antifungal synergistic drug combinations dataset 1. by Xing Chen (140292)

Number of unique barcode sequences. by Lauren M. Childs (593877)

LOOCV was implemented in three antifungal synergistic drug combinations datasets. by Xing Chen (140292)

Identification of +TIPs required for MT plus-end targeting of dynein-dynactin in the <i>C</i>. <i>elegans</i> early embryo. by Daniel J. Barbosa (4288462)

“…<p><b>(A)</b> Central confocal section in a <i>C</i>. …”

Impact of DMSO on cumulus expansion of COCs during IVM. by Xuan Li (137217)

The C-terminal tyrosine of α-tubulin is required for centration/rotation of the nucleus-centrosome complex but not for MT tip tracking of dynactin. by Daniel J. Barbosa (4288462)

“…<p><b>(A)</b> Cartoon depicting the C-terminal tail of TBA-1 and TBA-2, the major α-tubulin isotypes in early embryogenesis. …”

Engineering of p150^DNC-1 mutants for functional characterization of dynactin's MT binding activity. by Daniel J. Barbosa (4288462)

“…<p><b>(A)</b> Cartoon of the dynactin complex and its interaction with MTs and end-binding protein (EB). …”

Nonequilibrium Electrokinetic Effects in Beds of Ion-Permselective Particles by Felix C. Leinweber (2670697)

“…Electrokinetic transport of fluorescent tracer molecules in a bed of porous glass beads was investigated by confocal laser scanning microscopy. …”

Nonequilibrium Electrokinetic Effects in Beds of Ion-Permselective Particles by Felix C. Leinweber (2670697)

“…Electrokinetic transport of fluorescent tracer molecules in a bed of porous glass beads was investigated by confocal laser scanning microscopy. …”

Nonequilibrium Electrokinetic Effects in Beds of Ion-Permselective Particles by Felix C. Leinweber (2670697)

“…Electrokinetic transport of fluorescent tracer molecules in a bed of porous glass beads was investigated by confocal laser scanning microscopy. …”

Schematic illustrating the similar nature of synergistic drug combinations. by Xing Chen (140292)

Macroscopic current recordings from L1 muscle cells show that thymol is an inhibitor of L-AChR and UNC-49 receptor. by Guillermina Hernando (553795)

Simultaneous 3D localization of cytochrome-<i>c</i> (Cc) and H2B-GFP showing Cc redistribution during specific stages of apoptosis. by Frédérique Nolin (2151472)