MSKE and Z-FY-CHO inhibit cell migration and invasion. by Liza J. Burton (615553)

“…<p>(<b>A</b>) Migration on collagen and (<b>B</b>) Invasion on matrigel was performed using a boyden chamber with or without treatment of MDA-MB-468 or MDA-MB-231 cells with MSKE or Z-FY-CHO. …”

Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N‑Termini by Purva P. Bhojane (1839205)

“…Chymotrypsin cleavage of 16 N-terminal residues results in an active enzyme with a decreased stability. The space sampled by the disordered N-termini of R67 DHFR was investigated using small angle neutron scattering. …”

Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N‑Termini by Purva P. Bhojane (1839205)

“…Chymotrypsin cleavage of 16 N-terminal residues results in an active enzyme with a decreased stability. The space sampled by the disordered N-termini of R67 DHFR was investigated using small angle neutron scattering. …”

CUX1 directly binds to the ER-α promoter and is antagonized by Cat L inhibitor (Z-FY-CHO) or MSKE. by Liza J. Burton (615553)

“…<p>(<b>A</b>) MCF-7 Neo and MCF-7 cells overexpressing Snail (MCF-7 Snail) or (<b>C</b>) MDA-MB-468 cells were utilized for ChIP analysis with anti-CUX1 antibody or goat IgG as a negative control to immunoprecipitate, and qRT-PCR with primers to ER-α promoter containing the CUX1 consensus site or primers to a promoter region that does not contain CUX1 consensus site (ER-α Control) as another control. …”

Comparison of pre-treatment and post-treatment fluorescence imaging in orthotopic LS174T mouse models. by Hannah M. Hollandsworth (8992103)

“…<p>The mouse received 25 μg m5A-700 24 hours before treatment. Prior to PIT treatment (a), tumor margins had a distinct NIR fluorescence signal (maximum tumor fluorescence 4.54). …”

TREM-B1 crosslinking reduces CLEC-2 induced thrombocyte degranulation. by Vanessa Turowski (3180918)

“…<p>(A) Co-crosslinking of CLEC-2 and TREM-B1 with the thrombocyte specific mab 8G8 and 1E9 decreased degranulation (lower panels) compared to co-crosslinking an irrelevant antibody and 8G8 (upper panels). …”

Kidney histologic and functional abnormality in SCA7^140Q/5Q mice. by William Miller (11991)

“…<p>A) Kidney hematoxylin and eosin staining (H&E) of 40-week-old SCA7^140Q/5Q and WT littermates, B-C) absolute and relative kidney weights, and D) urine Bradford assay results of 28-week-old SCA7^{<i>140Q/5Q</i>} and WT littermates. …”

Silencing of MINK significantly reduced EV71 replication in a siRNA concentration-dependent manner. by Shi Yun Leong (699834)

“…Parallel transfection of scrambled siRNA served as a knockdown control. MINK protein expression was observed to decrease in a dose-dependent manner across siRNA concentration. …”

Plasma amino acids and metabolic profiling of dairy cows in response to a bolus duodenal infusion of leucine by Hassan Sadri (771911)

“…The elevation of plasma Leu concentrations after the infusion led to a significant decrease (<i>P</i><0.05) in the plasma concentrations of isoleucine, valine, glycine, and alanine. …”

Mitochondrial Ca²⁺ uptake contributes to cell death induced by Aβ oligomers. by Sara Sanz-Blasco (271498)

“…<p><i>A</i>. Cerebellar granule cells were co-loaded with mitotracker green and TMRM 10 nM and washed. …”

Subsistence-level groups experiencing lifestyle change are a potential model for uncovering GxE interactions. by Amanda J. Lea (11790137)

“…Bidirectional arrows indicate factors that could either increase or decrease during urban transitions. (<b>B</b>) Studies such as The Turkana Health and Genomics Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref018" target="_blank">18</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref019" target="_blank">19</a>], The Orang Asli Health and Lifeways Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref020" target="_blank">20</a>], The Pacific Planetary Health Initiative, Madagascar Health and Environmental Research [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref021" target="_blank">21</a>–<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref023" target="_blank">23</a>], The Tsimane Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref024" target="_blank">24</a>], and The Shuar Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref025" target="_blank">25</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref026" target="_blank">26</a>] all combine anthropological and biomedical data collection in transitioning societies and are thus poised to uncover GxE interactions in the context of evolutionary mismatch. …”

TCF21 modulates expression of <i>AHR</i> and its downstream genes. by Juyong Brian Kim (4011689)

“…(e, f) TCF21 knockdown by siRNA decreased expression of both <i>IL1A</i> and <i>MMP1</i>, while dioxin alone increased expression of both genes. …”

Analysis of the various EcFicTA complexes in solution. by Frédéric V. Stanger (585551)

“…<p>(<i>a</i>) SEC-MALLS analysis of EcFicTA (green), EcFicTA_E28G (pink), EcFicT_G55RA (cyan) and EcFicT_G55RA_E28G (purple) reveals in each case a 1:1 complex in solution at an eluting concentration of 15 μM. …”

Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human a... by Jing-Ti Deng (696563)

“…ROCK inhibition with GSK429286A reduced serum-induced phosphorylation of LC₂₀ at T18 and S19, MYPT1 at T853 and Par-4 at T163, while ZIPK inhibition by HS38 reduced only LC₂₀ diphosphorylation. …”

<i>Mycobacterium tuberculosis</i> universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth by Lisa N. Glass (4285222)

“…Biochemical, immunochemical and mass spectrometric studies have shown that Rv2623 harbors pT and specifically identified threonine 237 as a phosphorylated residue. Relative to wild-type Rv2623 (Rv2623_WT), a mutant protein in which T237 has been replaced with a non-phosphorylatable alanine (Rv2623_T237A) exhibits decreased interaction with the Rv1747 FHA I domain and diminished growth-regulatory capacity. …”

Abundance of antisense transcripts in <i>RTR1/RRP6</i> double deletion strain phenocopies <i>rrp6Δ</i> cells. by Jose F. Victorino (8595885)

“…Each genotype clustered together illustrating a high degree of reproducibility between biological replicates with WT values groups as Cluster IV, <i>rtr1Δ</i> values grouped as Cluster III, <i>rtr1Δ rrp6Δ</i> grouped as Cluster II, and <i>rrp6Δ</i> grouped as Cluster I. …”

In vivo validation of hippocampal avoidance with radiation in rats treated with brain irradiation with hippocampal avoidance. by C. K. Cramer (833725)

“…The radiation-induced phosphorylation of Histone H2A.X in the hippocampus is significantly decreased when the brain is irradiated with hippocampal avoidance, * P = 0.012 (by student t-test). …”

Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

Expression of osteoblast differentiation markers following <i>BST2</i> knockdown. by Su-Hyang Yoo (3160983)

Bump diffusion due to input and spiking noise. by Raymond Wang (7527374)

“…(<b>A</b>) Diffusion decreases with bump number under linear mapping and remains largely constant under circular mapping. …”