Frequency of active pubchem bioassay compounds across protein target domains. by Tyler William H. Backman (3726991)

“…The quantity of targets with each domain among the PubChem BioAssay data, and within the <i>H. sapiens</i> proteome (all proteins, including those not screened in PubChem BioAssay) are shown on the right in both plots. <b>(A)</b> The top 30 Pfam domains with the greatest number of active FDA approved drugs, in decreasing order. …”

Possible mechanisms for the differential binding of phosphorylated and unphosphorylated hepadnavirus core protein to B23 and I2PP2A. by Laurie Ludgate (336722)

“…The negative charges introduced by CTD phosphorylation decrease the overall positive charge of the CTD and thus weaken the electrostatic interactions with the acidic regions of B23 and I2PP2A (<i>II</i>). …”

Additional file 2 of A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy by Andreas Schulte (5331596)

“…Supplementary Material 2: Flow scheme of RAMOS and modified TOM for comparison of NDIR CO2 sensor and Δp sensor for CTR measurement A Simplified flow scheme of RAMOS with Δp sensor, oxygen sensor, inlet and outlet valve. …”

Image 1_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Image 4_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Supplementary file 1_Case Report: A case of reversible tracheal diameter Mounier-Kuhn syndrome and literature review.docx by Lu-xia Kong (21191087)

“…We encountered an 81-year-old male MKS patient whose diagnosis was delayed, and subsequently experienced a significant decrease in tracheal diameter post-diagnosis, marking the first documented case of reversible tracheal diameter in MKS patients. …”

Image 5_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Table 3_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Table_1_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Table_2_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Table_3_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach - Fig 10 by Elsje Pienaar (658131)

“…<p>Bacteria in all subpopulations increase more slowly following MXF treatment interruption, compared to GFX and LVX (A-D). Lines show means of 210 <i>in silico</i> granulomas, with infection starting at day 0, daily FQ treatment starting at day 380 (arrows). …”

Silencing GRK2 and GRK3 attenuate C3aR desensitization but GRK5 and GRK6 do not. by Qiang Guo (218747)

“…<p>(A) shRNA control, (B) GRK2, (C) GRK3, (D) GRK5 and (E) GRK6 KD cells were loaded with Indo-1 (1 µM), stimulated with C3a (100 nM) for 5 min and intracellular Ca²⁺ mobilization was determined (black solid lines). …”

Table_4_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Image 3_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Table 4_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

A chemical similarity network of identified metabolites was used to visualize OGTT-associated changes in metabolite levels following an OGTT in women. by Caitlin Campbell (507411)

Table 2_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Selected model input parameters for a simulation model of strategies to prevent mother-to-child transmission of HIV in Zimbabwe: Pediatric data. by Andrea L. Ciaranello (188588)

“…</p><p>*“Without sdNVP exposure” refers to situations in which sdNVP was not received, or was received in combination with short-course zidovudine or other antenatal/intrapartum medications which may decrease risk of NVP-associated NNRTI-resistant HIV <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020224#pone.0020224-Arrive1" target="_blank">[19]</a>.…”

Long-Term Retrospective Analysis of Mackerel Spawning in the North Sea: A New Time Series and Modeling Approach to CPR Data by Teunis Jansen (114728)

“…<div><p>We present a unique view of mackerel (<em>Scomber scombrus</em>) in the North Sea based on a new time series of larvae caught by the Continuous Plankton Recorder (CPR) survey from 1948-2005, covering the period both before and after the collapse of the North Sea stock. …”