Quantum Mechanical Enhancement of Rate Constants and Kinetic Isotope Effects for Water-Mediated Proton Transfer in a Model Biological System by James W. Mazzuca (3664111)

“…Deuteration of the donor and acceptor proton are shown to decrease the reaction rate constant by a factor of 50, and this is another indicator that tunneling plays an important role in this proton transfer mechanism.…”

Image_1_An Intronic Alu Element Attenuates the Transcription of a Long Non-coding RNA in Human Cell Lines.JPEG by Rosario Pérez-Molina (3468674)

“…We observed that the Alu sequence acts as an enhancer element based on reporter gene assays while CRISPR-Cas9 deletions of the Alu sequence in K562 cells resulted in a marked transcriptional upregulation of Linc00441 and a decrease in proliferation. …”

Table_5_The Importance of Environmentally Acquired Bacterial Symbionts for the Squash Bug (Anasa tristis), a Significant Agricultural Pest.xlsx by Tarik S. Acevedo (11518621)

“…The squash bug, Anasa tristis (Coreoidea: Coreidae), is a significant pest of human agriculture in its own right and also causes damage to crops due to its capacity to transmit a bacterial plant pathogen. …”

CB₁ immunostaining of the cerebral cortex, hippocampus and substantia nigra in a six-month-old Beagle dog. by Jessica Freundt-Revilla (4237699)

“…<p>Within the frontal lobe of the cerebral cortex, there is an intense CB₁ immunoreactivity of fibres surrounding unstained neuronal bodies in layers V and VI (A; arrow). In figure B, layer I appears almost devoid of CB₁ immunoreactivity and layer II and III express strong immunoreactivity. …”

A schematic diagram representing the hypothetical mechanism by which nicotinamide protects against thiotepa-induced neurodegeneration in the brain of the developing rat. by Najeeb Ullah (338312)

“…Nicotinamide, as indicated by the X sign, inhibits several key elements in the apoptotic cascade beginning with the down-regulation of Bax, a decrease in cytochrome c release from mitochondria to cytosol, inhibition of activated caspase-3 and cleavage of PARP-1 and necrosis by the inhibition of PARP-1 activation and prevention of ATP and NAD⁺ depletion (red arrow), resulting in protection against thiotepa-induced apoptotic and possible necrotic cell death.…”

Image_2_Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy.pdf by Yasuo Kitajima (3493466)

“…Using this model, we found that proteasome dysfunction in adult muscles resulted in muscle wasting and a decrease in the myofiber size. Immunoblotting analysis showed that the amounts of ubiquitinated proteins were markedly higher in muscles of Rpt3-deficient mice than in those of the control mice. …”

Table_1_Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy.pdf by Yasuo Kitajima (3493466)

“…Using this model, we found that proteasome dysfunction in adult muscles resulted in muscle wasting and a decrease in the myofiber size. Immunoblotting analysis showed that the amounts of ubiquitinated proteins were markedly higher in muscles of Rpt3-deficient mice than in those of the control mice. …”

DataSheet1_ProDiVis: a method to normalize fluorescence signal localization in 3D specimens.pdf by Kyle T. Nguyen (19723936)

“…<p>A common problem in confocal microscopy is the decrease in intensity of excitation light and emission signal from fluorophores as they travel through 3D specimens, resulting in decreased signal detected as a function of depth. …”

Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood by Anthony W. S. Chan (253096)

“…Along with progressive cognitive and motor impairment, neuroimaging revealed a progressive reduction in striatal volume. Magnetic resonance spectroscopy at 48 months of age revealed a decrease of N-acetylaspartate (NAA), further suggesting neuronal damage/loss in the striatum. …”

Data_Sheet_1_Inferring the Significance of the Polyamine Metabolism in the Phytopathogenic Bacteria Pseudomonas syringae: A Meta-Analysis Approach.PDF by Leandro Solmi (12509083)

“…Furthermore, data suggest that a proper bacterial response to oxidative conditions requires a decrease in polyamine production. …”

Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in <i>Dictyostelium discoideum</i> by William S. Swatson (4591873)

“…This is followed by later unique transcriptional changes and a protein kinase A dependent decrease in catalase A and three superoxide dismutase enzymes. …”

Data_Sheet_1_Identification of a New de Novo Mutation Underlying Regressive Episodic Ataxia Type I.DOCX by Zeynep S. Karalok (5556416)

“…<p>Episodic ataxia type 1 (EA1), a Shaker-like K⁺channelopathy, is a consequence of genetic anomalies in the KCNA1 gene that lead to dysfunctions in the voltage-gated K⁺ channel Kv1. 1. …”

Reproductive behaviour of a North African endemic damselfly, <i>Platycnemis subdilatata</i> (Odonata: Platycnemididae) and probable senescence effects by Rassim Khelifa (2867750)

“…Clutch size and egg deposition rate pattern through age showed an increase in early mature life followed by a decrease later on.</p>…”

A Survey on Data Reproducibility in Cancer Research Provides Insights into Our Limited Ability to Translate Findings from the Laboratory to the Clinic by Aaron Mobley (412870)

“…</p><p>Methods and Findings</p><p>To examine a microcosm of the academic experience with data reproducibility, we surveyed the faculty and trainees at MD Anderson Cancer Center using an anonymous computerized questionnaire; we sought to ascertain the frequency and potential causes of non-reproducible data. …”

Online supplementary data from Projecting a second wave of COVID-19 in Japan with variable interventions in high-risk settings by Sung-mok Jung (10457737)

“…Projections showed that a 50% decrease in the high-risk transmission is required to keep <i>R</i> < 1 in both locations—a level necessary to maintain control of the epidemic and minimize the risk of resurgence.…”

Table_3_The Expansion of a Single Bacteriophage Leads to Bacterial Disturbance in Gut and Reduction of Larval Growth in Musca domestica.docx by Xinyu Zhang (14029)

Representation of Sound Objects within Early-Stage Auditory Areas: A Repetition Effect Study Using 7T fMRI by Sandra Da Costa (734188)

“…Their semantic representations were shown to yield repetition suppression effects, i. e. a decrease in activity during exposure to a sound that is perceived as belonging to the same source as a preceding sound. …”

Image_3_Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy.pdf by Yasuo Kitajima (3493466)

“…Using this model, we found that proteasome dysfunction in adult muscles resulted in muscle wasting and a decrease in the myofiber size. Immunoblotting analysis showed that the amounts of ubiquitinated proteins were markedly higher in muscles of Rpt3-deficient mice than in those of the control mice. …”

Image_1_The Expansion of a Single Bacteriophage Leads to Bacterial Disturbance in Gut and Reduction of Larval Growth in Musca domestica.tiff by Xinyu Zhang (14029)

Table_4_The Expansion of a Single Bacteriophage Leads to Bacterial Disturbance in Gut and Reduction of Larval Growth in Musca domestica.docx by Xinyu Zhang (14029)