Image3_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. …”

Largazole (L) and largazole ester (E) inhibit ubiquitin E1 in a dose dependent manner <i>in vitro</i>. by Dana Ungermannova (334910)

“…In addition, DMSO has no effect on the formation of the thioester linkage as seen in lane 2 of both gels. 50 nM E1 was incubated with decreasing concentrations of L (A) or E (C) for 15 minutes at room temperature followed by addition of a cocktail containing ATP and Ub-F. …”

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis by Lei Zhang (38117)

“…Reducing the intracellular levels of glucosylceramide with a glucosylceramide synthase inhibitor resulted in decreased secretion of KALLIKREIN proteases by wild type keratinocytes, but not by <i>smsk</i> mutant keratinocytes. …”

Trends in Incidence of Stroke and Transition of Stroke Subtypes in Rural Tianjin China: A Population-Based Study from 1992 to 2012 by Bin Li (39349)

“…A total of 14,538 residents in a township of Ji County in Tianjin, China participated in the study since 1985. …”

Table_2_Effects of Ramadan and Non-ramadan Intermittent Fasting on Body Composition: A Systematic Review and Meta-Analysis.pdf by Joana M. Correia (10033139)

“…Conversely, we observed a significant increase in fat-free mass when comparing pre- to post-intervention in a within design fashion (0.306, 95% CI [0.133, 0.48], p = 0.001). …”

Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a <i>Rat</i> Model by Xiaolin Xu (493031)

“…</p><p>Conclusions</p><p>The initial stage of root resorption repair did not change significantly and was followed by a dramatic repair period before stabilizing. The most serious tooth movement relapse occurred immediately after the appliance was removed, and then the tooth completely returned to the original position.…”

A Randomized Controlled Study on the Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients with Essential Hypertension by Wei-Jun Zhou (456887)

“…The augmentation index at a HR of 75 bpm (AIxatHR75) was significantly decreased (29%±11% to 25%±12%; <i>P</i> = 0.026) in the bisoprolol group only. …”

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer by George M. Philips (206900)

“…<div><h3>Objective</h3><p>Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. …”

Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: a cross-sectional study by Hisanori Miyashita (6587044)

“…The cumulative ocular UV exposure (COUV) was calculated. A logistic regression analysis was used for multivariate analysis.…”

Image_1_mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma.tiff by Masaki Michishita (4100770)

“…In mice transplanted with CTBp-derived spheres, everolimus treatment significantly decreased tumor volume compared to control. These results reveal that the mTOR signaling pathway may be a potential to be a therapeutic target in both cancer cells and CSCs. …”

Image_1_Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury.tiff by Alfonso Rubio-Navarro (503533)

“…Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. …”

Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions by Hideaki Nakamura (402108)

“…<div><p>Tumor hypoxia contributes to a biologically aggressive phenotype and therapeutic resistance. …”

DataSheet_1_The Specific Alteration of Gut Microbiota in Diabetic Kidney Diseases—A Systematic Review and Meta-Analysis.docx by Yuwei Wang (178411)

“…Compared to HC, the bacterial richness of patients with DKD was significantly decreased, and the diversity indexes were decreased but not statistically, companying with a distinct beta diversity. …”

DataSheet1_Ceramide Aminoethylphosphonate as a New Molecular Target for Pore-Forming Aegerolysin-Based Protein Complexes.PDF by Teresa Balbi (8710875)

“…In Mytilus haemocytes, short term exposure (max. 1 h) to the OlyA6/PlyB mixture induced lysosomal membrane destabilization, decreased phagocytic activity, increased Annexin V binding and oxyradical production, and decreased levels of reduced glutathione, indicating rapid damage of endo-lysosomal and plasma membranes and oxidative stress. …”

Table_1_The Clustering Analysis of Time Properties in Patients With Cerebral Small Vessel Disease: A Dynamic Connectivity Study.docx by Wenwen Yin (1877125)

“…The changes in the DFC are associated with altered cognition in CSVD. This study provides a better explanation of the potential mechanism of CSVD patients with cognitive impairment from the perspective of DFC.…”

Image4_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. …”

Image9_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. …”

Image11_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. …”

Image8_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress adaptation, and structural remodeling. …”

Table3_Causal analysis of the gut microbiota in differentiated thyroid carcinoma: a two-sample Mendelian randomization study.XLSX by Zheng Quan (17624256)

“…</p><p>Results: IVW analysis revealed a dual role of the GM in thyroid carcinoma. The phylum Actinobacteria (OR, 0.249 [95% CI, 0.121–0.515]; p < 0.001) was associated with a decreased risk of DTC. …”