miR-22 inhibits DCs from expressing IL-6 and driving Th17 cells differentiation. by Xue Liang (449130)

“…The bar plots are expressed in the form of mean±SD. * means a significant decrease appears when compared with the control group (p-value < 0.05, t test), while ** represents a significant increase relative to the control (p-value < 0.05, t test).…”

Relative Energies of α and β Isomers of Keggin Dodecatungstogallate by Karthik M. Sundaram (2652337)

“…This finding is evaluated by analysis of the X-ray crystal structure α-K₂Na₃[GaW₁₂O₄₀]·9.3H₂O [trigonal, space group <i>P</i>3₂21, <i>a</i> = 18.9201(13) Å, <i>b</i> = 18.9201(13) Å, <i>c</i> = 12.5108(12) Å, <i>Z</i> = 3, <i>T</i> = 100(2)K], comparison of the Shannon and Prewitt radii and Pauling electronegativities of Al³⁺ and Ga³⁺, and insight from density functional theory calculations, which predicted <i>E</i>_β − <i>E</i>_α = 0.32 kcal mol^-1.…”

Alterations in tone and FM sweeps evoked activity during repetitive stress. by Ghattas Bisharat (20706928)

“…Activity rates decreased at moderate sound intensities, while activity at high intensities remained comparable to baseline intensities (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003012#pbio.3003012.g002" target="_blank">Fig 2D</a>, 2-way ANOVA, condition F = 16.1, <i>p</i> = 6.02 × 10⁻⁰⁵, nested ANOVA (mouse nested within session) F = 16.1, <i>p</i> = 5.9 × 10⁻⁰⁵, mean ± SE). …”

Data Sheet 1_Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.pdf by Gufeng Gao (16835753)

“…Analysis of lung tissues revealed enhanced levels of p-PKC, p-IRS-1(Ser318), and p-ERK, whereas the expression of total IRS-1 decreased significantly (p < 0.05). In PASMCs stimulated with PDGF-BB, a similar trend of increased p-PKC, p-IRS-1(Ser318), and p-ERK levels was observed, along with a decrease in IRS-1 expression. …”

Three-month-old TgCRND8 mice differ from NTg in their homeostatic response to total sleep deprivation. by Jessica Colby-Milley (755301)

“…(<b>B)</b> TgCRND8 show a significant decrease in time spent awake during the rebound period in comparison to baseline. …”

DataSheet_1_Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.xlsx by Chun-Shu Wong (6750368)

“…CD4:CD8 and CD4 T- and B-cell PB subsets partly normalized compared to HC post-ART as viral load decreased. Strikingly in LN, ART led to a rapid decrease in interferon signaling pathways and an increase in Tfh, germinal center and IgD^-CD27^- B cells, consistent with histological findings of post-ART follicular hyperplasia. …”

Data_Sheet_1_Detection of COVID-19 epidemic outbreak using machine learning.pdf by Giphil Cho (14129502)

“…</p>Objective<p>In this study, we aimed to propose a machine learning-based method to predict the transmission trend of COVID-19 and a new approach to detect the start time of new outbreaks by analyzing epidemiological data.…”

Effects of TNFR neutralizing antibodies on mTORC1 and caspase activity. by Valentina Guerrini (3396608)

“…Full-length blots are presented in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007223#ppat.1007223.s008" target="_blank">S8 Fig</a>. …”

Types of decisions. by Yael Appelboom (20570815)

“…Mental effort rose from 17h onwards higher values, whereas a decrease in comfortability was seen from 21h onwards.…”

Data_Sheet_1_Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats.docx by Gaudencio Fernández-Miranda (6650009)

“…Quiescent MetS cardiomyocytes showed a decrease in Ca²⁺ spark frequency, amplitude, and spark-mediated Ca²⁺ leak. …”

<i>Lp</i> knockdown significantly impairs oogenesis and affects Vg expression and localization. by Iryna Stryapunina (17867390)

“…(C) Western blot quantification from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011145#pgen.1011145.g001" target="_blank">Fig 1C</a> showing an accumulation of Vg in the fat body and a decrease of Vg in the ovaries upon <i>Lp</i> knockdown; samples of five tissues, three biological replicates (REML variance component analysis: ** = p < 0.01; **** = p < 0.0001). …”

Inclusion and exclusion criteria. by Laurence Weinberg (2960238)

“…Scoping review registered on OSF registries (<a href="https://osf.io/4mg7n" target="_blank">https://osf.io/4mg7n</a>).…”

Table 1_Evaluation of F18 enterotoxigenic Escherichia coli intestinal attachment and early disease onset in nursery pigs.docx by Elizabeth M. Due (22819034)

“…Introduction<p>Enterotoxigenic Escherichia coli (ETEC) is a major cause of post-weaning diarrhea and reduced performance in nursery pigs. …”

DataSheet5_An Herbal Product Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via Regulating NF-κB/TNF-α Signaling in Macrophages.xlsx by Fei Jing (298892)

“…Fuzheng Huayu (FZHY) formula, a Chinese herbal product, is effective in treating pulmonary fibrosis in our previous study. …”

Image_2_Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis.tif by Xue-Pei Zhang (10650773)

“…Objectives<p>This study aims to investigate if addition of fibroblast-stromal cell markers to a classification of synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA).…”

Knockdown of Ice-Binding Proteins in <i>Brachypodium distachyon</i> Demonstrates Their Role in Freeze Protection by Melissa Bredow (3396572)

“…IBP-knockdown lines also demonstrated a significant decrease in viability following freezing to −8°C, with some lines showing only two-thirds the survival seen in control lines. …”

DataSheet8_Transcriptional time course after rotator cuff repair in 6 month old female rabbits.XLSX by Laura S. Vasquez-Bolanos (11242737)

“…Many were also significantly enriched at 2 weeks, with the addition of NIF/NF-kappaB signaling, transcription in response to hypoxia, and mRNA stability alongside many additional pathways. There was also a shift in transcriptional activity at 4 weeks post-repair with significantly enriched pathways for lipids, hormones, apoptosis, and cytokine activity, despite an overall decrease in the number of differentially expressed genes. …”

Treatment with TCA and S1P2 agonist induces S1PR2 expression and attenuates ROCK1/RHOA expression; inhibition of S1PR2 reverses TCA- or S1P2-mediated effect on ROCK1/RHOA expressio... by Aya Miyagawa-Hayashino (386487)

“…Pretreatment with JTE-013 reversed the TCA- or S1P2-mediated decrease in <i>ROCK1</i> expression. (E) <i>RHOA</i> mRNA expression exhibited a tendency similar to that of <i>ROCK1</i>. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes by Chet Raj Ojha (4258624)

“…The expression of toll-like receptor 3 (TLR3) was significantly increased with all three strains of ZIKV; pharmacological and genetic inhibition of TLR3 caused a decrease in viral titers and in viral-induced inflammatory response in infected astrocytes. …”