Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Data_Sheet_1_Prevalence and Prognosis of HFimpEF Developed From Patients With Heart Failure With Reduced Ejection Fraction: Systematic Review and Meta-Analysis.docx by Yibo He (4805139)

“…</p><p>Conclusion: Around 22.64% of patients with HFrEF would be treated to become HFimpEF, who would then obtain a 56% decrease in mortality risk. Meanwhile, HFimpEF is associated with lower heart failure hospitalization. …”

Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes by Yung-Ting Kuo (736349)

“…The C57BL6/J mouse was subjected to a hindlimb sciatic axotomy. A PQQ-containing ALZET® osmotic pump (equivalent to 4.5 mg/day/kg b.w.) was implanted subcutaneously into the right lower abdomen of the mouse. …”

Presentation_1_Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.pptx by Chun-Shu Wong (6750368)

“…CD4:CD8 and CD4 T- and B-cell PB subsets partly normalized compared to HC post-ART as viral load decreased. Strikingly in LN, ART led to a rapid decrease in interferon signaling pathways and an increase in Tfh, germinal center and IgD^-CD27^- B cells, consistent with histological findings of post-ART follicular hyperplasia. …”

DataSheet6_An Herbal Product Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via Regulating NF-κB/TNF-α Signaling in Macrophages.xlsx by Fei Jing (298892)

“…Fuzheng Huayu (FZHY) formula, a Chinese herbal product, is effective in treating pulmonary fibrosis in our previous study. …”

Data_Sheet_1_The 1-aminocyclopropane-1-carboxylic acid deaminase-producing Streptomyces violaceoruber UAE1 can provide protection from sudden decline syndrome on date palm.pdf by Khawla J. Alwahshi (13158522)

“…Thus, the number of conidia of Fs recovered from plants pre-treated with both BCAs was comparable, but significantly (P < 0.05) reduced compared to plants without any BCA treatment. In addition, a significant (P < 0.05) decrease in ACC levels of both the root and shoot tissues was detected inSv + Fs seedlings to almost similar levels of healthy seedlings. …”

Video1_Balancing welfare and habitat damage in pigs (Sus scrofa) under extensive farming: an ethological approach for determining the effects of group composition and environmental... by Edoardo Collarini (10146350)

“…In enrichment conditions with straw, we found a significant decrease in anxiety-related, affiliation, and excavation behaviours levels, and a significant increase in non-invasive exploration behaviours. …”

Resistance of genetically engineered <i>Rel</i>2-expressing immune-enhanced by Yuemei Dong (17509)

“…Detailed statistical information of infection assays with N, range, prevalence, <i>p</i>-values of prevalence determined by Chi-square test, median (with or without zeros), <i>p</i>-values of infection intensity (with or without zeros) calculated through Kruskal-Wallis and Mann-Whitney tests, and % decrease of oocysts, ookinetes, or sporozoites loads are presented in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002458#ppat.1002458.s008" target="_blank">Table S3</a>.…”

image1_Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and I... by Babita Singh (811405)

“…Treatment with BME before or after MPTP administration has a protective effect on dopaminergic neurons, as evidenced by a significant decrease in GFAP immunostaining and expression of inducible nitric oxide synthase (iNOS) in the substantia nigra region; however, the degree of improvement was more prominent in mice receiving BME treatment before MPTP administration. …”

Data Sheet 5_Global trends in ambient particulate matter-attributable ischemic heart disease among the elderly (1990–2021).csv by Yangxi Zeng (20710481)

“…Although BAPC projections indicate a continued decline, a potential rise in pollution around 2035 may slow the rate of decrease or temporarily flatten the downward trajectory.…”

Detection of 1′′–3′ gcADPR in lysates of bacteria expressing the SARM1 TIR domain. by Jeremy Garb (18405156)

“…<p>(a) Schematic representation of the experiment. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Image2_Computational analysis of cancer cell adhesion in curved vessels affected by wall shear stress for prediction of metastatic spreading.TIFF by Nahid Rahmati (18618076)

“…Quantitative analysis shows a 25% decrease in the wall shear stress in low-shear regions and a 58.5% increase in the high-shear region. …”

Table1_Balancing welfare and habitat damage in pigs (Sus scrofa) under extensive farming: an ethological approach for determining the effects of group composition and environmental... by Edoardo Collarini (10146350)

“…In enrichment conditions with straw, we found a significant decrease in anxiety-related, affiliation, and excavation behaviours levels, and a significant increase in non-invasive exploration behaviours. …”

Data_Sheet_1_Macrogenomics reveal the effects of inter-cropping perilla on kiwifruit: impact on inter-root soil microbiota and gene expression of carbon, nitrogen, and phosphorus c... by Ning Gao (153779)

“…The results showed that intercropping with Perill caused a decrease in most soil nutrients, soil enzyme activities, and had a significant impact on the microbial (bacteria and fungi) diversity. …”

Data_Sheet_1_Nitrogen Source Matters: High NH4/NO3 Ratio Reduces Cannabinoids, Terpenoids, and Yield in Medical Cannabis.pdf by Avia Saloner (12705275)

“…This study demonstrates a dramatic impact of N form on cannabis plant function and production, with a 46% decrease in inflorescence yield with the increase in NH₄ supply from 0 to 50%. …”

Rate-specific template effects on the STI (Wisler et al., 2025) by Alan Wisler (14583050)

“…</p><p dir="ltr">Wisler, A., Fletcher, A., & Mefferd, A. (2025). Does the spatiotemporal index (STI) overestimate instability in slow speech? …”

Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative Stress Pathway by Yuan Weifeng (3175970)

“…In addition, LPS intratracheal instillation induced marked oxidative damage, such as a decrease in total anti-oxidation products and an increase in malondialdehyde (MDA), as well as up-regulation of oxidation enzymes. …”

DataSheet2_Transcriptional time course after rotator cuff repair in 6 month old female rabbits.XLSX by Laura S. Vasquez-Bolanos (11242737)

“…Many were also significantly enriched at 2 weeks, with the addition of NIF/NF-kappaB signaling, transcription in response to hypoxia, and mRNA stability alongside many additional pathways. There was also a shift in transcriptional activity at 4 weeks post-repair with significantly enriched pathways for lipids, hormones, apoptosis, and cytokine activity, despite an overall decrease in the number of differentially expressed genes. …”

Key characteristics of the included publications. by Laurence Weinberg (2960238)

“…Scoping review registered on OSF registries (<a href="https://osf.io/4mg7n" target="_blank">https://osf.io/4mg7n</a>).…”