EPB-113 binds to hexameric nsp15 protein. by Benjamin Van Loy (9496075)

“…<p>(A) Thermal shift assay showing the decrease in T_m when 6 µM of nsp15 protein was incubated with 100 µM EPB-113. …”

Data_Sheet_1_Coastal Flooding in the Balearic Islands During the Twenty-First Century Caused by Sea-Level Rise and Extreme Events.zip by Pau Luque (11248140)

“…<p>Sea-level rise induces a permanent loss of land with widespread ecological and economic impacts, most evident in urban and densely populated areas. …”

Table_1_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.DOCX by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

Anti-HBV activity of CDM-3008 in primary cultured human hepatocytes. by Yutaka Furutani (5620139)

“…(C) Measurement of HBV DNA copies in PXB cells after 7 days of CDM-3008 treatment. HBV DNA was decreased with 0.1–100 μM CDM-3008 in a dose-dependent manner. …”

Image_6_Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome.jpeg by Meghan H. Shilts (5900660)

“…</p>Objective<p>Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.</p>Methods<p>Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.…”

Image_5_Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.TIF by Pei-Hui Ding (3909724)

“…In addition, silencing of either CASP4 or CASP1 can lead to a concurrent or reciprocal decrease in the expression of the other. …”

Table_1_Probiotics May Have Beneficial Effects in Parkinson's Disease: In vitro Evidence.DOCX by Luca Magistrelli (5037275)

“…Peripheral blood mononuclear cells (PBMCs) were isolated and co-cultured with a selection of probiotics microorganisms belonging to the lactobacillus and bifidobacterium genus. …”

Table_2_Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.DOCX by Lanier Heyburn (7055039)

“…</p>Methods<p>In this study, using a rodent model of relBOP and western blotting for protein expression we showed the differential expression of various neuropathological proteins like TDP-43, tight junction proteins (claudin-5, occludin, and glial fibrillary acidic protein (GFAP)) and a mechanosensitive protein (piezo-2) in different regions of the brain at different intensities and frequency of blast.…”

Image1_Magnolol Attenuates Right Ventricular Hypertrophy and Fibrosis in Hypoxia-Induced Pulmonary Arterial Hypertensive Rats Through Inhibition of the JAK2/STAT3 Signaling Pathway... by Minyi Fu (11605909)

“…Magnolol (6, 6′, 7, 12-tetramethoxy-2,2′-dimethyl-1-β-berbaman, C18H18O2) is a compound isolated from Magnolia Officinalis. …”

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice by Kayla M. Quinnies (3749686)

“…Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations. …”

Table_1_Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.DOCX by Chanokchon Setthawongsin (6568634)

“…<p>Background: Vincristine (VCR) is a mono-chemotherapy for canine transmissible venereal tumor (CTVT). …”

Table_3_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Mice were treated with a single dose of CTX (100 mg/kg) at post-natal day 21 and sacrificed 47 days later when primordial follicles surviving chemotherapy developed to the antral stage. …”

Image_6_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

Image_3_Short-Chain Fatty Acids Alleviate Hepatocyte Apoptosis Induced by Gut-Derived Protein-Bound Uremic Toxins.TIF by Mingjuan Deng (11504476)

“…Propionate reduction of apoptosis was associated with improving mitochondria dysfunction and oxidative stress in a manner involving reducing Caspase-3 expression, ROS production, and increasing the Bcl-2/Bax level. …”

Image_3_p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy.pdf by Maomao Sun (2427562)

“…After sepsis stimulation, the autophagy levels of RTECs increased temporarily, followed by a sharp decrease. Autophagy inhibition was accompanied by an increased renal tubular injury score. …”

Data_Sheet_1_Conditioned Medium of Human Menstrual Blood-Derived Endometrial Stem Cells Protects Against MPP+-Induced Cytotoxicity in vitro.docx by Han Li (10885)

“…In this study, human neuroblastoma SH-SY5Y cells were exposed to neurotoxicant 1-methyl-4-phenylpyridinium (MPP⁺) for inducing a range of response characteristics of PD. After culturing this cell model with 24 h/48 h collected MenSCs-CM for different days, cell viability, pro-inflammation cytokines, mitochondrial membrane potential (ΔΨm), oxidative stress, and cell apoptosis were detected. …”

PEDV and PDCoV infection impairs the cilium. by Tenghan Zhuang (22238809)

“…Notably, infection by either porcine epidemic diarrhea virus (PEDV) or porcine deltacoronavirus (PDCoV) resulted in a significant decrease in both the percentage of cells with cilium and the average ciliary length across all three porcine cell lines (<i>C-D, F-G, and I-J</i>). …”

Image 4_Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.tiff by Mireille Ngokingha Tchouto (20812811)

“…</p>Results<p>While the B cell proportion in young and non-immune experienced animals did not significantly change from 2 to 5 days post osteotomy in the hematoma, we found a significant decrease of the B cell proportion in the immune experienced mice, which was accompanied by the decreased expression of B cell specific genes, suggesting a specific response in immune experienced animals. …”

Image_2_Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.TIFF by Pei-Hui Ding (3909724)

“…In addition, silencing of either CASP4 or CASP1 can lead to a concurrent or reciprocal decrease in the expression of the other. …”

Light-driven Locomotion of Underwater Bubbles on Ultrarobust Paraffin-impregnated Laser-ablated Fe₃O₄‑doped Slippery Surfaces by Zhouchen Huang (6672761)

“…The underlying principle is that when the NIR was applied, UGB would be actuated to slide along the NIR trace because the irradiated domain melts for a slippery surface within 1.0 s. Once the NIR is removed, the liquefied paraffin would be reconfigured to solid phase for pinning a moving UGB within 0.5 s. …”