Early insights into the characteristics and evolution of clinical parameters in a cohort of patients prescribed sacubitril/valsartan in Germany by Rolf Wachter (326776)

“…Patients with ≥1 heart failure (HF) diagnosis during the study period, ≥1 additional HF diagnosis in the full history of the database, and ≥1 prescription for an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and a β-blocker during the study period, without a prescription for sac/val (<i>n</i> = 25,264), were included as a reference cohort. …”

Data Sheet 1_Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.pdf by Alexandra Prodea (22617710)

“…Introduction<p>Breast cancer poses a significant health problem for women worldwide due to late-stage diagnosis, toxicity of standard therapy and drug resistance. …”

Table_1_Causal links between serum micronutrients and epilepsy: a Mendelian randomization analysis.XLSX by Haohao Chen (8070887)

“…Background<p>Micronutrient levels play a critical role in epilepsy. This study investigates the impact of micronutrient levels on epilepsy via Mendelian randomization (MR).…”

Table_1_Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis.docx by Yulian Pang (14002071)

“…Background<p>Migraine is a central nervous system disorder involving neuronal and vascular factors. …”

Data_Sheet_1_A Novel Idiopathic Atrial Calcification: Pathologic Manifestations and Potential Mechanism.docx by Bowen Li (200859)

“…Background<p>Cardiac calcification is a type of ectopic pathologic calcification of unknown etiology and mechanisms. …”

Causal associations between kidney function and aortic valve stenosis: a bidirectional Mendelian randomization analysis by Wanqian Pan (18147420)

“…</p> <p>Genetically predicted decreased eGFR may be associated with a raised risk of AVS (OR = 0.045, <i>p</i> = 1.317e-04 by IVW; OR = 0.002, <i>p</i> = 0.004 by MR-Egger, OR = 0.091, <i>p</i> = 0.057 by WM). …”

Data_Sheet_7_Predictors of sequence capture in a large-scale anchored phylogenomics project.PDF by Renato Nunes (5704595)

“…Sequence capture, also known as anchored hybrid enrichment, is a method to produce reduced representation libraries for NGS sequencing. …”

3a6 cell line response to different substances capable of depleting the levels of mitochondrial DNA. by Mercedes Fernández-Moreno (659000)

“…The analysis of mtDNA copy numbers reflect that treatment with the highest concentration (0.5 mM) for 144 hours decreased the levels of mtDNA in treated cells nearly 98% compared to those of untreated cells. 8x10⁴ cells were plated in each experiment for treatment with a reagent. …”

Image 2_Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model.tif by Tianyin Wang (10272824)

“…C-C motif chemokine-like receptor 2 (CCRL2) is a unique seven-transmembrane domain receptor that is upregulated by inflammatory signals and mediates leucocyte migration. …”

In vitro fermentation characteristics of ruminant diets using ethanol extract of brown propolis as a nutritional additive by Maria de Fátima Falcão Gomes (12802294)

“…Dry matter degradability of diet decreased exponentially as a function of the increase in dose (y = 678.55×dose–0.271). …”

Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme by JohnCarlo Kristofich (5687573)

“…A previously identified point mutation increases the enzyme’s ability to catalyze the newly needed reaction (required for arginine biosynthesis) but decreases its ability to catalyze its native reaction (required for proline biosynthesis). …”

DataSheet_1_A Strigolactone Signal Inhibits Secondary Lateral Root Development in Rice.pdf by Huwei Sun (4541788)

“…The effects of exogenous GR24 (a synthetic SL analogue), 1-naphthylacetic acid (NAA; an exogenous auxin), 1-naphthylphthalamic acid (NPA; a polar auxin transport inhibitor), and abamine (a synthetic SL inhibitor) on rice secondary LR development were investigated. …”

Subspecialized radiology reporting: productivity and impact on the turnaround times for radiology reports in a middle-income country by Nupur Verma (664047)

“…Data were collected over two 24-month periods (2015-2016 for general reporting and 2017-2018 for subspecialized reporting). Results: A total of 208,516 reports were generated. The median report TAT decreased from 49.1 h and 52.9 h in 2015 and 2016, respectively, to 16.1 h and 15.2 h in 2017 and 2018, respectively (p < 0.001). …”

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice—A Model for Tauopathy Studies by Agneta Mewes (136833)

“…Neonatal slices displayed a constant high vitality level, while the vitality of adult slice cultures decreased significantly upon cultivation. …”

DataSheet_2_Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization.zip by Dongze Liu (12993036)

“…MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.</p>Results<p>From a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). …”

Fimasartan reduces clinic and home pulse pressure in elderly hypertensive patients: A K-MetS study by Eun Joo Cho (6569522)

“…However, pulse pressure, a better predictor of cardiovascular events in the elderly, decreased more in elderly than in nonelderly patients by -8.2 ± 0.3 in elderly and -7.0 ± 0.2 mmHg (p<0.0001), respectively, after adjustment for confounding factors. …”

Data_Sheet_1_The APSES Gene MrStuA Regulates Sporulation in Metarhizium robertsii.DOC by Wenjing Yang (466552)

“…In addition, transcription levels of two central regulators of asexual development, AbaA and WetA, were significantly reduced in the mutant; furthermore, the transcription levels of other sporulation related genes, such as Mpk, Phi, Med, Aco, Flu, and FlbD, also decreased significantly. …”

Table_2_A Multilevel Assessment of Plasticity in Response to High-Altitude Environment for Agama Lizards.pdf by Yin Qi (314969)

“…Both lizards were capable of acclimating to the high-altitude environment without sacrificing their performance in bite force, but they also showed high plasticity in tail display behavior by either decreasing the intensity of a specific display component (P. forsythii) or by the trade-off between display components (P. axillaris). …”

Supplementary Material for: Cyanotic nephropathy in an adult patient with Eisenmenger syndrome: A case report and literature review. by Zhu F. (7343156)

“…Abstract Introduction: Cyanotic nephropathy, a rare disease characterized by proteinuria, decreased estimated glomerular filtration rate (eGFR), thrombocytopenia, polycythemia, and hyperuricemia, may occasionally be secondary to cyanotic congenital heart disease. …”

Table_1_Measuring the inequalities in healthcare resource in facility and workforce: A longitudinal study in China.DOCX by Enhong Dong (10812742)

“…Objective<p>The study aimed to measure time trends of inequalities of the geographical distribution of health facilities and workforce in Shanghai from 2010 to 2016 and used a spatial autocorrelation analysis method to precisely detect the priority areas for optimizing health resource reallocation in metropolises like Shanghai in developing countries.…”