Amx that only possesses the highly conserved TM2 domain is a potent inhibitor of Notch signaling. by Jose L. Salazar (3233190)

“…<p>(A, D) Schematic of proteins generated from <i>UAS-3xHA</i>::<i>amx</i>^<i>FL</i> and <i>UAS-3xHA</i>::<i>amx</i>^<i>ΔECD</i> transgenes. …”

Image_1_Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.TIF by Gangqiang Guo (3278922)

“…Western blotting revealed that the expression of Wnt-16 protein was significantly decreased in SLE.</p><p>Conclusion: Our results suggest that hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE.…”

Dynamine 3 as a diagnostic and prognostic biomarker in pancreatic cancer: Implications for early detection and targeted therapy by Fatih Yay (20606054)

“…<p>Dynamins are defined as a group of molecules with GTPase activity. Among them, DNM3 has gained recognition in oncology for its tumor suppressor role. …”

Image_1_Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification.JPEG by Muge Qile (6917804)

“…<p>K_IR2.1 potassium channels, producing inward rectifier potassium current (I_K1), are important for final action potential repolarization and a stable resting membrane potential in excitable cells like cardiomyocytes. …”

Image_2_Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.TIF by Gangqiang Guo (3278922)

“…Western blotting revealed that the expression of Wnt-16 protein was significantly decreased in SLE.</p><p>Conclusion: Our results suggest that hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE.…”

Factors influencing sedentary behaviour: A system based analysis using Bayesian networks within DEDIPAC by Christoph Buck (3445619)

“…<div><p>Background</p><p>Decreasing sedentary behaviour (SB) has emerged as a public health priority since prolonged sitting increases the risk of non-communicable diseases. …”

<i>GADD45a</i> promoter activity and functional promoter region in response to mechanical stress. by Sumegha Mitra (579813)

“…Comparatively, 18% CS-induced luciferase activity was significantly decreased in 0.8 kb, 0.4 kb and 0.2 kb fragments. (<b>D</b>) <i>In silico</i> analysis of <i>GADD45a</i> promoter region −371 to −133 by Genomatix predicted binding sites for transcription factor SP1. …”

Post-hospital mortality in children aged 2-12 years in Tanzania: A prospective cohort study by Duncan K. Hau (5628965)

“…Factors associated with mortality were determined using Cox regression analysis.</p><p>Results</p><p>A total of 506 participants were enrolled. In-hospital mortality rate was 7.7% (39/506). …”

Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population by Xiaomu Kong (447734)

Image1_Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study.pdf by Maria Consiglia Trotta (6243830)

“…Introduction:<p>The purine analog 6-thioguanine (6TG), an old drug approved in the 60s to treat acute myeloid leukemia (AML), was tested in the diabetic retinopathy (DR) experimental in vivo setting along with a molecular modeling approach.</p>Methods:<p>A computational analysis was performed to investigate the interaction of 6TG with MC1R and MC5R. …”

Robotic Right Lower Lobe Anteromedial Basilar (S7 + S8) Segmentectomy: A Case Report and Discussion by Ankit Dhamija (7901640)

“…This is especially evident in patients with emphysema and obesity. The authors provide a video and description of a patient with a nodule isolated to S7+S8 of the right lower lobe.…”

Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study by Belinda J. Gabbe (193450)

“…</p><p>Methods and findings</p><p>A population-based, prospective cohort study using the Victorian State Trauma Registry (VSTR) was undertaken. …”

ChIP Reveals That RPA Is a Limiting Factor in <i>dmc1Δ</i> Cells by Rebecca Johnson (77303)

“…The difference in ChIP efficiencies for wild-type and <i>dmc1</i>Δ cells is greatest for the site far from VDE-DSB1, implying that as resection proceeds it becomes more difficult to compete for Rfa1, which may be stably bound to ssDNA created earlier, close to DSB sites.</p><p>(A) Close to a Spo11-DSB hotspot, the ChIP enrichment decreases with repair in wild-type cells but not in <i>dmc1</i>Δ cells.…”

SNAP-25 (1-197) binds to syntaxin-1A, and the interaction is enhanced by Ser187 phosphorylation. by Dilara Koc (22431017)

“…<b>(C and D)</b> PMA treatment further decreases neurotransmitter release when a low level of SNAP-25 cleavage is present. …”

Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study by Dylan D. Thomas (8173575)

“…<div><p>Objective</p><p>Medium chain triglycerides (MCT) have unique metabolic properties which may improve insulin sensitivity (Si) and beta cell function but data in humans are limited. We conducted a 6-week clinical trial of MCT oil supplementation.…”

Data_Sheet_1_A New Predictive Model for the Prognosis of MDA5+ DM-ILD.PDF by Qian Niu (425660)

“…Poor prognosis was found more frequently in patients who were older, clinically amyopathic variant of dermatomyositis (CADM), and/or with short duration, short interval of DM and ILD, long length of stay, fever, dyspnea, non-arthralgia, pulmonary infection, pleural effusion (PE), high total computed tomography scores (TCTs), ground-glass opacity (GGO), consolidation score, reticular score and fibrosis score, decreased forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), albumin, A/G, glomerular filtration rate (GFR) and tumor necrosis factor α (TNFα), high titer of anti-MDA5, proteinuria, high levels of monocyte, lactate dehydrogenase (LDH), ferritin (FER), neuron specific enolase (NSE) and glucocorticoid, antibiotic, antiviral, and non-invasive positive pressure ventilation (NPPV). …”

Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis by Fa-Ping Wang (3358667)

Cryo-EM structures of Map1 bound to ribosomes via expansion segment ES27a. by Alexandra G. Knorr (15333351)

“…<p>(<b>A</b>) Concentrated eluate obtained from Map1-TAP affinity purification shown on a 12% Nu-PAGE. …”

Treatment with a fecal microbiota transplant following spinal cord injury reduced anxiety-like behaviour. by Emma K. A. Schmidt (8307642)

“…<p>Animals were tested in the elevated plus maze 3 weeks following surgeries. <b>(A)</b> Representative images from the motion tracking software used to analyze the elevated plus maze. …”

PRMT5 stabilizes vCyclin protein expression in a manner dependent on its methyltransferase activity. by Danping Niu (10912688)

“…<p>(A-B) Effect of PRMT5 on vCyclin expression. First, HEK293T cells were cotransfected with fixed amounts of vCyclin expression plasmid and increasing amounts of PRMT5 expression plasmids. …”