Purified recombinant WT-C100Flag dimer and trimer showed reduced Aβ production. by Joo In Jung (650746)

“…Aβ38, Aβ40 and Aβ42 levels decreased in dimer compared to monomer, and the Aβ levels for trimer were under detection limits. …”

A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy by Min Zheng (131026)

“…Quantification of mRNA expression in urinary sediment has emerged as a novel strategy for studying renal diseases. Considering the numerous molecules involved in DN development, a high-throughput platform with parallel detection of multiple mRNAs is needed. …”

Image_5_Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis.tiff by Florence Jeny (4978466)

“…Monocytes-derived (MD) macrophages have recently been demonstrated to play a major role especially in pulmonary sarcoidosis. …”

DataSheet1_Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor.docx by Daniel Hunziker (2673724)

“…<p>The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration. …”

Measuring mean promoter activity and cell-to-cell variability for a library of Zap1 target promoters. by Lucas B. Carey (289856)

“…<p>(<i>A</i>) The transcription factor Zap1 is induced by decreasing the concentration of zinc in the growth medium. …”

Table_2_Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner.docx by Irina V. Milanova (6880862)

“…Microglia responded to the obesogenic conditions by a shift of substrate utilization with decreased glutamate and glucose metabolism in the active period of the animals, and an overall increase of lipid metabolism, as indicated by gene expression evaluation. …”

Non-Alcoholic Fatty Pancreas Disease Pathogenesis: A Role for Developmental Programming and Altered Circadian Rhythms by Rebeca Carter (540949)

“…Analyses of CCG expression demonstrated a phase shift in CLOCK (−4.818, p<0.01), REV-ERB-α (−1.4,p<0.05) and Per2 (3.27,p<0.05) in association with decreased amplitude in BMAL-1 (−0.914,p<0.05) and PER2 (1.18,p<0.005) in Ob_Ob compared to Con_Con. 2-way ANOVA revealed significant interaction between MO and post-weaning OD in expression of CLOCK (p<0.005), PER1 (p<0.005) and PER2 (p<0.05) whilst MO alone influenced the observed rhythmic variance in expression of all 5 measured CCG.…”

Table_3_Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner.docx by Irina V. Milanova (6880862)

“…Microglia responded to the obesogenic conditions by a shift of substrate utilization with decreased glutamate and glucose metabolism in the active period of the animals, and an overall increase of lipid metabolism, as indicated by gene expression evaluation. …”

Morphology, Nucleation, and Isothermal Crystallization Kinetics of Poly(ε-caprolactone) Mixed with a Polycarbonate/MWCNTs Masterbatch by Gumede, Thandi P.

“…Isothermal crystallization experiments performed by DSC showed an increase in the overall crystallization kinetics of PCL with increases in MWCNTs as a result of their nucleating effect. Nevertheless, the crystallinity degree of the nanocomposite containing 4 wt % MWCNTs decreased by about 15% in comparison to neat PCL. …”
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Data_Sheet_1_Prevention of Neural Tube Defects in Europe: A Public Health Failure.pdf by Joan K. Morris (7769147)

“…<p>Objective: Thirty years ago it was demonstrated that folic acid taken before pregnancy and in early pregnancy reduced the risk of a neural tube defect (NTD). Despite Public Health Initiatives across Europe recommending that women take 0.4 mg folic acid before becoming pregnant and during the first trimester, the prevalence of NTD pregnancies has not materially decreased in the EU since 1998, in contrast to the dramatic fall observed in the USA. …”

Table_2_Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.XLSX by Jia-Ying Lin (2247670)

“…The single-SNP analyses revealed that n-3 fatty acids are likely linked to a decreased risk of AD through FADS cluster, highlighting the significance of the FADS gene in the fatty acids synthesis pathway in the development of AD.…”

Conversion from Tacrolimus to Cyclosporine A Improves Glucose Tolerance in HCV-Positive Renal Transplant Recipients by Ammon Handisurya (315084)

“…</p><p>Results</p><p>After conversion, both fasting and challenged glucose levels decreased significantly. This was mainly attributable to a significant amelioration of post-prandial dynamic glucose sensitivity as measured by the oral glucose sensitivity-index OGIS [422.17 (370.82–441.92) vs. 468.80 (414.27–488.57) mL/min/m2, p = 0.005), which also resulted in significant improvements of the disposition index (p = 0.017) and adaptation index (p = 0.017) as markers of overall glucose tolerance and beta-cell function. …”

Development of a multivariable prediction model for identification of patients at risk for medication transfer errors at ICU discharge by Liesbeth B. E. Bosma (6650735)

“…<div><p>Introduction</p><p>Discharge from the intensive care unit (ICU) is a high-risk process, leading to numerous potentially harmful medication transfer errors (PH-MTE). …”

Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: A Meta-Analysis of Randomised Controlled Trials by Rémy Boussageon (172049)

“…We cannot exclude a 33% reduction or a 64% increase in cardiovascular mortality. …”

DataSheet_1_Epidemiological Characteristics of Peripheral T-Cell Lymphoma: A Population-Based Study.docx by Shuo Liu (108276)

<i>Trypanosoma</i> ingestion reduces the reproductive fitness in <i>A</i>. <i>coluzzii</i>. by Constentin Dieme (8294856)

“…<p>(A) The graph shows median fold change of <i>vitellogenin</i> expression in mosquitoes fed on mice infected by <i>Trypanosoma</i> (Tryp) or by <i>P</i>. …”

Table_1_Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.XLSX by Jia-Ying Lin (2247670)

“…The single-SNP analyses revealed that n-3 fatty acids are likely linked to a decreased risk of AD through FADS cluster, highlighting the significance of the FADS gene in the fatty acids synthesis pathway in the development of AD.…”

Supplementary Material for: The association between migration and prevalence of allergic diseases: a systematic review and meta-analysis by Wong Q.Y.A. (16928025)

“…Being an immigrant was also associated with a decreased risk of asthma (pOR = 0.56, 95% CI = 0.44, 0.72). …”

Image1_Identification of a chromatin regulator signature and potential prognostic ability for adrenocortical carcinoma.TIF by Junwu Li (13431636)

“…<p>Objective: Adrenocortical carcinoma (ACC) is a rare malignant tumor. Chromatin regulators (CRs) can drive epigenetic changes, which have been considered as one of the most vital hallmarks of tumors. …”

Image_1_Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.jpeg by Jia-Ying Lin (2247670)

“…The single-SNP analyses revealed that n-3 fatty acids are likely linked to a decreased risk of AD through FADS cluster, highlighting the significance of the FADS gene in the fatty acids synthesis pathway in the development of AD.…”