Image_1_BcMettl4-Mediated DNA Adenine N6-Methylation Is Critical for Virulence of Botrytis cinerea.TIF by Zhengang Miao (8262354)

“…Knockout of BcFDH led to reduced sclerotium formation, while disruption of BcMFS2 resulted in dramatically decreased conidium formation and pathogenicity. These observations indicated that 6mA provides potential epigenetic markers in B. cinerea and that BcMettl4 regulates virulence in this important plant pathogen.…”

Data_Sheet_3_Comparative Transcriptional Analysis of Lactobacillus plantarum and Its ccpA-Knockout Mutant Under Galactooligosaccharides and Glucose Conditions.PDF by Chen Chen (6544)

“…In total, 489 genes (16%) were differentially transcribed in the wild-type L. plantarum grown on glucose and GOS and the value is decreased to 7% due to the loss of ccpA. Only 6% genes were differentially expressed when the wild-type and the ccpA mutant were compared on GOS. …”

Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of <em>Drosophila melanogaster</em> by Ning Wang (108353)

“…RNAi-mediated silencing of <em>Tap42</em> using the binary <em>Gal4/UAS</em> system and two disc drivers, <em>pnr-</em> and <em>ap-Gal4</em>, not only decreased survival rates but also hampered the development of wing discs, resulting in a remarkable thorax cleft and defective wings in adults. …”

Data_Sheet_1_Comparative Transcriptional Analysis of Lactobacillus plantarum and Its ccpA-Knockout Mutant Under Galactooligosaccharides and Glucose Conditions.PDF by Chen Chen (6544)

“…In total, 489 genes (16%) were differentially transcribed in the wild-type L. plantarum grown on glucose and GOS and the value is decreased to 7% due to the loss of ccpA. Only 6% genes were differentially expressed when the wild-type and the ccpA mutant were compared on GOS. …”

Supplementary file 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Data_Sheet_2_Comparative Transcriptional Analysis of Lactobacillus plantarum and Its ccpA-Knockout Mutant Under Galactooligosaccharides and Glucose Conditions.PDF by Chen Chen (6544)

“…In total, 489 genes (16%) were differentially transcribed in the wild-type L. plantarum grown on glucose and GOS and the value is decreased to 7% due to the loss of ccpA. Only 6% genes were differentially expressed when the wild-type and the ccpA mutant were compared on GOS. …”

Image_8_LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.TIF by Yaqiong Feng (9604034)

“…Toxicity tests proved that toxicity of secondary metabolites (SMs) produced by VmLaeA deletion mutant (ΔVmlaeA) was markedly decreased in comparison with wild-type (WT). …”

Table_2_BcMettl4-Mediated DNA Adenine N6-Methylation Is Critical for Virulence of Botrytis cinerea.XLSX by Zhengang Miao (8262354)

“…Knockout of BcFDH led to reduced sclerotium formation, while disruption of BcMFS2 resulted in dramatically decreased conidium formation and pathogenicity. These observations indicated that 6mA provides potential epigenetic markers in B. cinerea and that BcMettl4 regulates virulence in this important plant pathogen.…”

Schematic overview of the down-stream genes regulated by eIF3a and the resultant functional effects. (A) by Darius J. R. Lane (381080)

“…Second, when eIF3a expression is abrogated, such as occurs in hypoxic tissues that are typical of advanced tumors <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057273#pone.0057273-Chen2" target="_blank">[77]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057273#pone.0057273-Dellas1" target="_blank">[78]</a>, there is: <b>(i)</b> down-regulation of NDRG1, leading to a loss of differentiation and increased metastasis/invasion (shown herein); <b>(ii)</b> up-regulation of p27^kip1, resulting in the inactivation of the cell cycle and inhibited proliferation <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057273#pone.0057273-Dong2" target="_blank">[7]</a>; and <b>(iii)</b> decreased expression of RRM2 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057273#pone.0057273-Dong1" target="_blank">[6]</a>, preventing DNA synthesis and growth.…”

Data Sheet 2_Vitamin A deficiency attenuates cardiac rupture in Stra6-deficient hearts following ischemic injury.zip by Yannick Smolenski (22253482)

“…Background<p>Stimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development. …”

Table_2_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.DOCX by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Data_Sheet_11_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.PDF by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model by Tracy-Shi Zhang Fang (16641433)

“…We further show that USP30 loss leads to increased levels of mitophagy in dopaminergic neurons and attenuates dopaminergic neuronal loss and the behavioral deficits induced by αSyn following stereotaxic injection of AAV-A53T-SNCA into the substantia nigra (SN). Moreover, this functional rescue is associated with significantly decreased pathological phospho-S129 αSyn in dopaminergic neurons of the SN in Usp30 KO mice. …”

Data Sheet 2_Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.pdf by Yarou Gao (20620991)

“…Mechanistic studies indicated that these compounds affect virus internalization during the early infection stages. In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. …”

Data_Sheet_3_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.PDF by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Data_Sheet_9_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.PDF by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Table_4_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.xlsx by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Data_Sheet_4_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.PDF by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Data_Sheet_8_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.PDF by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”

Table_3_The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila.xlsx by Zhen-huang Ge (7829171)

“…During the TP, the level of CsrA is decreased by inhibiting the degradation of IHFB and promoting the degradation of the accumulated CsrA via a ClpP-dependent manner as well. …”