Table 1_Global, regional, and national trends in DALYs for blindness and vision loss in teenagers and young adults, 1990–2019: an age-period-cohort analysis based on the Global Bur... by Juan Lu (275293)

“…The APC model estimated a global net drift at −0.43% (95% CI: −0.45% to −0.42%) per year, ranging from −0.92% (95% CI: −0.94% to −0.91%) in low-middle socio-demographic Index (SDI) regions to −0.03% (95% CI: −0.07% to −0.0005%) in high SDI regions. …”

Image_6_Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia–reperfusion injury based on integrating fecal metabonomics and 16S rDNA... by Ximeng Ding (14018481)

“…The present study has shown a significant effect of G. elata Blume in improving cerebral ischemia–reperfusion injury (CIRI). …”

Table2_Network Pharmacology-Based Strategy for the Investigation of the Anti-Osteoporosis Effects and Underlying Mechanism of Zhuangguguanjie Formulation.XLSX by Wang Gong (11510329)

“…The ovariectomized (OVX) mice were treated with normal saline or ZG for 4 weeks after ovariectomy following a series of analyses. The bone mass density (BMD) and trabecular parameters were examined by micro-CT. …”

Data_Sheet_3_Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge.PDF by Shuangshuang Wan (4014089)

“…Thus, we aimed to investigate whether Mongolian gerbils, which present a range of human pathological conditions, can been used in studies on CDI. …”

DataSheet1_Dapagliflozin Reduces Apoptosis of Diabetic Retina and Human Retinal Microvascular Endothelial Cells Through ERK1/2/cPLA2/AA/ROS Pathway Independent of Hypoglycemic.ZIP by Yuxin Hu (454917)

“…Dapagliflozin reduced the level of ROS caused by high glucose, decreased the expression of cleaved-caspase3 and the ratio of BAX/Bcl-2. …”

S3 Fig - by Leonardo Campagna (3262872)

“…<p>Genetic differentiation within and outside of association peaks. <b>A and B</b>. F_ST values calculated for 5 kb windows inside and outside association peaks. …”

Data_Sheet_1_Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.PDF by Martin Vielreicher (10957656)

“…Multiphoton Second Harmonic Generation (SHG) microscopy, is able to visualize the sterical topology of the collagen-I fibrillar network in 3D, in a minimally invasive and label-free manner. Penetration depths exceed those of conventional visible light imaging and can be further optimized through employing decalcification or optical clearing processing ex vivo. …”

Table_2_Metagenome Analysis of Intestinal Bacteria in Healthy People, Patients With Inflammatory Bowel Disease and Colorectal Cancer.xlsx by Yongshun Ma (9737837)

“…Objectives<p>Several reports suggesting that the intestinal microbiome plays a key role in the development of inflammatory bowel disease (IBD) or colorectal cancer (CRC), but the changes of intestinal bacteria in healthy people, patients with IBD and CRC are not fully explained. …”

Data_Sheet_1_Direct Oral Anticoagulants vs. Warfarin in Latin American Patients With Atrial Fibrillation: Evidence From Four post-hoc Analyses of Randomized Clinical Trials.docx by Fuwei Liu (4447765)

“…Adjusted hazard ratios (HRs) and 95% CIs were pooled by a random-effects model using an inverse variance method.…”

Semi-knockout YAP rescue heart function from valve thickening. by Wei Yu (43094)

“…<p>(A) Gross front view of hearts from 9-month-old <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i>; <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i><i>;Yap</i>^<i>fl/+</i> and <i>Vgll4</i>^<i>fl/-</i><i>;Yap</i>^<i>fl/+</i> hearts. …”

Table_2_SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.docx by Helene Sertznig (9649127)

“…Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by inducing the expression of IFN-stimulated genes (ISGs) including potent host restriction factors. …”

Data_Sheet_2_Immunological response and temporal associations in myocarditis after COVID-19 vaccination using cardiac magnetic resonance imaging: An amplified T-cell response at th... by Hajnalka Vago (4411354)

“…</p>Methods<p>We assembled a CMR-based registry of potentially COVID-19 vaccination-related myocarditis cases. …”

Table1_Research on the quality markers of antioxidant activity of Kai-Xin-San based on the spectrum–effect relationship.DOCX by Xiaoxiao Shan (8627850)

“…Combined with the results of GRA and OPLS-DA, peaks 1, 3, 5 (Sibiricose A6), 6, 13 (Ginsenoside Rg1), 15, and 24 in the fingerprints were screen out as the potential Q-makers of KXS for antioxidant effect. …”

Image_1_Lipidomics profiles of human spermatozoa: insights into capacitation and acrosome reaction using UPLC-MS-based approach.pdf by Xiaohong Cheng (275970)

“…While capacitation and the acrosome reaction, key processes before fertilization, involve substantial lipidomic alterations, a comprehensive understanding of the changes in human spermatozoa's lipidomic profiles during these processes remains unknown. …”

Image3_ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic.tif by Jennifer Streeter (19729264)

“…</p>Methods<p>We generated mice with homozygous floxed Opa1 and Atf4 alleles and a tamoxifen-inducible Cre transgene controlled by the human skeletal actin promoter to enable simultaneous depletion of OPA1 and ATF4 in skeletal muscle (mAO DKO). …”

DataSheet_1_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

Table_1_Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood–Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight... by Lin-Yan Huang (6274160)

“…Intravenous serum-derived exosome treatment may, therefore, provide a novel clinical therapeutic strategy for ischemic stroke.…”

Table2_Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway.XLSX by Lei Wang (6656)

“…Isoquercitrin (IQC) is a natural flavonoid with anti-oxidant and anti-apoptosis properties. …”

Data_Sheet_1_Sexual Dimorphisms of Protein-Coding Gene Profiles in Placentas From Women With Systemic Lupus Erythematosus.PDF by Hui-hui Li (12242504)

“…The results suggest that the SLE-dysregulated protein-coding genes in placentas may contribute to the pathophysiological progress of SLE pregnancies in a fetal sex-specific manner, leading to adverse pregnancy outcomes.…”

Video_7_Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study.MOV by Cláudia Fetter (9315074)

“…</p><p>Study Design: Hypertensive postmenopausal women were recruited and randomized for 12 weeks, twice a week, of supervised yoga or stretching video classes of 75 min for 12 weeks associated or not with respiratory technique. …”