Assessing the Potential of <i>N</i>‑Butyl‑l‑deoxynojirimycin (l‑NBDNJ) in Models of Cystic Fibrosis as a Promising Antibacterial Agent by Anna Esposito (2400814)

“…A significant decrease in the bacterial load in the airways was observed in the murine model of Pseudomonas aeruginosa chronic infection in the presence of l-NBDNJ, also accompanied by a modest reduction of inflammatory cells. …”

Models of G48D, M78I, G125C, and A146V RAD52 point mutants. by Abdulaziz B. Hamid (13804692)

Measurements using a Luminex assay of cytokines released by cells infected only with EBV, by co-transformed cells, and by PEL cell lines. by Mitchell Hayes (5334887)

CA3-CA1 synchronization of epileptiform discharges induced in aCSF with AMPA, NMDA, GABA antagonists depends on synaptic connections. by Olha Zapukhliak (10297334)

20251128 Herring et al_Nr4a1Floxed_Supplemental Figures by Jeffery Tessem (19417102)

“…Nr4a1 overexpression increases β-cell proliferation, and full body Nr4a1 knock out mice have decreased β-cell area. …”

Table_1_Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis.doc by Tian-Ping Zhang (6566606)

“…ALKBH5 rs8400 AA genotype, A allele frequencies were associated with the decreased risk of sputum smear-positive, while AA genotype frequency was related to the increased risk of hypoproteinemia in PTB patients. …”

DataSheet1.docx by Rui Hong Guo (4963240)

“…Interestingly, host contact increased the expression and secretion of V. vulnificus RtxA1 toxin, which was decreased and delayed by the rpoS mutation. …”

A meeting engaging community members to brainstorm ideas for the systems-map. by Thi Hoang Vu (13268033)

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Proportion of seclusion measures over time as a function of psychiatric admissions. by Alexandre Wullschleger (450938)

Buffer Assists Electrocatalytic Nitrite Reduction by a Cobalt Macrocycle Complex by Sarah E. Braley (10740327)

“…This work reports a combined experimental and computational study of the activation of an otherwise catalytically inactive cobalt complex, [Co­(TIM)­Br₂]⁺, for aqueous nitrite reduction. …”

Results of the AEMG (2A) and MEMG (2B) of each muscle. by Yu Hashiguchi (14593059)

Bidirectional grey-matter CBF changes induced by a hypercapnic challenge. by Juliana Zimmermann (10507091)

A failed <i>Shigella</i> dissemination in colonic epithelial cells. by Volkan K. Köseoğlu (12055346)

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Cas9 and LOF allele behavior in a 3 population model. by Georg Oberhofer (3401438)

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Proposed cutoff values for men in a very high risk region. by Gleb E. Svinin (18397739)

Sub-lethal concentrations of neonicotinoid insecticides at the field level affect negatively honey yield: Evidence from a 6-year survey of Greek apiaries by Robert G. Chambers (6635327)

“…Based on production function estimates, we found that sub-lethal concentrations of two widely used neonicotinoid insecticides (imidacloprid and thiamethoxam) detected in the nectar of flowers resulted in substantial losses in honey production for commercial beekeepers in our sample. By simulating a scenario with ideal pathogenic and environmental conditions, we found that the magnitude of the neonicotinoid effects decreases significantly under ideal conditions providing evidence for possible synergies at the field between neonicotinoids and environmental and pathogenic factors. …”