Data_Sheet_1_Direct Oral Anticoagulants vs. Warfarin in Latin American Patients With Atrial Fibrillation: Evidence From Four post-hoc Analyses of Randomized Clinical Trials.docx by Fuwei Liu (4447765)

“…Adjusted hazard ratios (HRs) and 95% CIs were pooled by a random-effects model using an inverse variance method.…”

Loss of Fnip1 synergizes with loss of TSC1 resulting in accelerated PKD and mTOR activation. by Ryan Centini (5390768)

“…<p>(A) Kidney-to-brain ratio graph comparing double null (<i>Tsc1</i>^<i>fl/fl</i><i>Mb1</i>Cre⁺<i>Fnip1</i>^<i>-/-</i>), <i>Fnip1</i>^<i>-/-</i> (<i>Fnip1</i>^<i>-/-</i><i>Tsc1</i>^<i>fl/+</i> <i>Mb1</i>Cre-), <i>Tsc1</i> null (<i>Fnip1</i>^<i>-/+</i> <i>Tsc1</i>^<i>fl/fl</i><i>Mb1</i>Cre⁺), and heterozygous (<i>Fnip1</i>^<i>-/+</i> <i>Tsc1</i>^<i>fl/+</i> <i>Mb1Cre</i>^-) mice at 5 weeks of age, showing an increase in kidney size of double null mice at an early age. …”

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation i... by Roy Eldor (380760)

Effect of Sfrp5 on Cytokine Release and Insulin Action in Primary Human Adipocytes and Skeletal Muscle Cells by Maren Carstensen (112706)

“…Sfrp5 had no effect on insulin signaling in untreated or in MCP-1 treated hSkMC. Thus, Sfrp5 lowered IL-6 release and NFκB phosphorylation in cytokine-treated human adipocytes, but not under normal conditions, and decreased insulin signaling in untreated human adipocytes. …”

Earlier Age at Type 2 Diabetes Diagnosis Is Associated with Increased Genetic Risk for Cardiovascular Disease by Hyunsuk Lee (2057740)

“…In UK Biobank, effect size of coronary artery disease (CAD) PRS on incident CAD was largest in people diagnosed of T2D at ages 30-39 (hazard ratio 2.25, 95% CI 1.56-3.26) and decreased for later-onset: 1.51 (1.30-1.75) at 40-49, 1.36 (1.24-1.50) at 50-59, and 1.30 (1.14-1.48) at 60-69 (<em>P</em>interaction=0.0031). …”

Sol-gel derived CeO2-Fe2O3 nanoparticles: Synthesis, characterization and solar thermochemical application by Bhosale, Rahul R.

“…For the synthesis of CeO2-Fe2O3, cerium nitrate hexahydrate and iron nitrate nonahydrate were first dissolved in ethanol and then PO was added to this mixture as a proton scavenger to achieve the gel formation. …”
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PrP^Sc accumulation in <i>TNFR1^−/−</i> lymph nodes requires LTβR signaling independent of <i>Prnp</i> expression. by Tracy O'Connor (143972)

“…Histoblots were performed on frozen sections from spleens (SPL; A–D) or mesenteric lymph nodes (mLN; E–H) from mice in each treatment group to visualize PrP^Sc deposition. …”

Table_2_SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.docx by Helene Sertznig (9649127)

“…Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by inducing the expression of IFN-stimulated genes (ISGs) including potent host restriction factors. …”

Data_Sheet_2_Immunological response and temporal associations in myocarditis after COVID-19 vaccination using cardiac magnetic resonance imaging: An amplified T-cell response at th... by Hajnalka Vago (4411354)

“…</p>Methods<p>We assembled a CMR-based registry of potentially COVID-19 vaccination-related myocarditis cases. …”

Table1_Research on the quality markers of antioxidant activity of Kai-Xin-San based on the spectrum–effect relationship.DOCX by Xiaoxiao Shan (8627850)

“…Combined with the results of GRA and OPLS-DA, peaks 1, 3, 5 (Sibiricose A6), 6, 13 (Ginsenoside Rg1), 15, and 24 in the fingerprints were screen out as the potential Q-makers of KXS for antioxidant effect. …”

Image_1_Lipidomics profiles of human spermatozoa: insights into capacitation and acrosome reaction using UPLC-MS-based approach.pdf by Xiaohong Cheng (275970)

“…While capacitation and the acrosome reaction, key processes before fertilization, involve substantial lipidomic alterations, a comprehensive understanding of the changes in human spermatozoa's lipidomic profiles during these processes remains unknown. …”

Image3_ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic.tif by Jennifer Streeter (19729264)

“…</p>Methods<p>We generated mice with homozygous floxed Opa1 and Atf4 alleles and a tamoxifen-inducible Cre transgene controlled by the human skeletal actin promoter to enable simultaneous depletion of OPA1 and ATF4 in skeletal muscle (mAO DKO). …”

PGJ₂ inhibits WM related NFκB activity. by James D. Nicholson (292697)

“…<p>A. Ni-DAB quenched fluorescence analysis of NFκB expression and nuclear localization. …”

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction by Daigo Hasegawa (4439164)

“…<div><p>Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. …”

DataSheet_1_Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.pdf by Yingjie Xie (8459550)

“…Therefore, that the proportion of CD11b⁺Gr-1⁺ cells increased in the spleen of tumor-bearing hosts may not be villainy after treatment, when these drugs suppress the immunosuppressive ability of CD11b⁺Gr-1⁺ cells and promote it mature to replenish dendritic cell, at the same time. Generally, JHD may be a complementary and alternative drug for attenuating the immunosuppressive status induced by hepatocellular carcinoma, possibly by promoting differentiation and inhibiting the immunosuppressive activity of MDSCs.…”

Upon depletion of corneal conventional dendritic cells, virus titers and the local corneal damages are significantly increased in primary herpes simplex keratitis. by Kai Hu (311882)

“…Keratitis severity was graded (n = 5/time point). <b>A:</b> Representative corneal photos of primary acute herpes simplex keratitis severity of the mice in different groups are shown. …”

Table_1_Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood–Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight... by Lin-Yan Huang (6274160)

“…Intravenous serum-derived exosome treatment may, therefore, provide a novel clinical therapeutic strategy for ischemic stroke.…”

RB1CC1 binds to and activates the promoters of <i>RB1</i>, <i>p16</i> and <i>p21</i>, cooperating with p53 and/or hSNF5. by Tokuhiro Chano (3912)

“…<p>(<b>A</b>) Chromatin immunoprecipitation (ChIP) assay was performed in HeLa cells. …”

Table2_Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway.XLSX by Lei Wang (6656)

“…Isoquercitrin (IQC) is a natural flavonoid with anti-oxidant and anti-apoptosis properties. …”

Data_Sheet_1_Sexual Dimorphisms of Protein-Coding Gene Profiles in Placentas From Women With Systemic Lupus Erythematosus.PDF by Hui-hui Li (12242504)

“…The results suggest that the SLE-dysregulated protein-coding genes in placentas may contribute to the pathophysiological progress of SLE pregnancies in a fetal sex-specific manner, leading to adverse pregnancy outcomes.…”